(10 nodes) Tetrahydrofolate interconversion network (Gallus gallus)

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Your Input:
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (651 aa)
	FTCD	Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family. (541 aa)
	MTHFS	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (200 aa)
	MTHFD2L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (342 aa)
	MTHFD1	Uncharacterized protein. (935 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (988 aa)
	DHFR	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. (190 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (476 aa)
	MTHFD2	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. (337 aa)
	ENSGALP00000068833	SHMT domain-containing protein. (497 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHFR	ENSGALP00000068833	ENSGALP00000041459	ENSGALP00000068833	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.	SHMT domain-containing protein.	0.919
DHFR	FTCD	ENSGALP00000041459	ENSGALP00000009880	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.	Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family.	0.953
DHFR	MTHFD1	ENSGALP00000041459	ENSGALP00000019224	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.	Uncharacterized protein.	0.985
DHFR	MTHFD1L	ENSGALP00000041459	ENSGALP00000020258	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.980
DHFR	MTHFD2	ENSGALP00000041459	ENSGALP00000057027	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.	0.806
DHFR	MTHFD2L	ENSGALP00000041459	ENSGALP00000017621	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.670
DHFR	MTHFR	ENSGALP00000041459	ENSGALP00000007330	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.917
DHFR	MTHFS	ENSGALP00000041459	ENSGALP00000010514	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.	0.800
DHFR	SHMT1	ENSGALP00000041459	ENSGALP00000047253	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.996
ENSGALP00000068833	DHFR	ENSGALP00000068833	ENSGALP00000041459	SHMT domain-containing protein.	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.	0.919
ENSGALP00000068833	MTHFD1	ENSGALP00000068833	ENSGALP00000019224	SHMT domain-containing protein.	Uncharacterized protein.	0.782
ENSGALP00000068833	MTHFD1L	ENSGALP00000068833	ENSGALP00000020258	SHMT domain-containing protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.782
ENSGALP00000068833	MTHFD2	ENSGALP00000068833	ENSGALP00000057027	SHMT domain-containing protein.	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.	0.827
ENSGALP00000068833	MTHFD2L	ENSGALP00000068833	ENSGALP00000017621	SHMT domain-containing protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.827
ENSGALP00000068833	MTHFR	ENSGALP00000068833	ENSGALP00000007330	SHMT domain-containing protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.936
ENSGALP00000068833	MTHFS	ENSGALP00000068833	ENSGALP00000010514	SHMT domain-containing protein.	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.	0.668
FTCD	DHFR	ENSGALP00000009880	ENSGALP00000041459	Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family.	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA.	0.953
FTCD	MTHFD1	ENSGALP00000009880	ENSGALP00000019224	Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family.	Uncharacterized protein.	0.997
FTCD	MTHFD1L	ENSGALP00000009880	ENSGALP00000020258	Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.996
FTCD	MTHFD2	ENSGALP00000009880	ENSGALP00000057027	Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family.	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.	0.994