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AGO2 AGO2 NFE2L2 NFE2L2 EMILIN1 EMILIN1 TEK TEK VASH2 VASH2 ENSGALP00000070665 ENSGALP00000070665 FGF1 FGF1 TNN TNN RAPGEF3 RAPGEF3 ACVRL1 ACVRL1 DLL1 DLL1 EMP2 EMP2 VEGFA VEGFA C5AR1 C5AR1 PGF PGF GPR25 GPR25 ANGPTL3 ANGPTL3 SIRT6 SIRT6 BTG1 BTG1 ITGB8 ITGB8 VEGFD VEGFD TBXA2R TBXA2R CYP1C1 CYP1C1 FGF18 FGF18 CCR5 CCR5 SP1 SP1 CTSH CTSH BMPER BMPER C5 C5 SMAD1 SMAD1 IL1B IL1B ENG ENG GAB1 GAB1 CYP1B1 CYP1B1 SASH1 SASH1 ZC3H12A ZC3H12A STIM1 STIM1 CCBE1 CCBE1 ISL1 ISL1 LRG1 LRG1 CD40 CD40 APELA APELA GREM1 GREM1 FGF2 FGF2 GATA2 GATA2 APLNR APLNR JUP JUP FLT1 FLT1 CHRNA8 CHRNA8 EPHA1 EPHA1 KDR KDR TLR3 TLR3 C3AR1 C3AR1 TGFBR2 TGFBR2 VEGFC VEGFC TIE1 TIE1 HMGA2 HMGA2 THBS1 THBS1 DDAH1 DDAH1 VEGFRKDRL VEGFRKDRL JCAD JCAD XBP1 XBP1 AQP1 AQP1 AGGF1 AGGF1 MYDGF MYDGF CHRNA7 CHRNA7 BRCA1 BRCA1 SIRT1 SIRT1 PIK3CD PIK3CD CD34 CD34 IL10 IL10 ITGB3 ITGB3
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (864 aa)
NFE2L2BZIP domain-containing protein. (593 aa)
EMILIN1EMI domain-containing protein. (610 aa)
TEKTEK receptor tyrosine kinase. (1128 aa)
VASH2Vasohibin 2. (356 aa)
ENSGALP00000070665Nuclear factor, erythroid 2. (326 aa)
FGF1Endothelial cell growth factor alpha; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with [...] (155 aa)
TNNTenascin N. (1125 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (1050 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (796 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
EMP2Epithelial membrane protein 2. (167 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). (674 aa)
C5AR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (247 aa)
GPR25Apelin receptor 2; Belongs to the G-protein coupled receptor 1 family. (365 aa)
ANGPTL3Fibrinogen C-terminal domain-containing protein. (464 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (378 aa)
BTG1Protein BTG1; Anti-proliferative protein; Belongs to the BTG family. (352 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (787 aa)
VEGFDPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (378 aa)
TBXA2RThromboxane A2 receptor. (361 aa)
CYP1C1Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CCR5Chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (355 aa)
SP1Transcription factor. (760 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (403 aa)
BMPERCrossveinless-2. (678 aa)
C5Complement C5. (1758 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
ENGZP domain-containing protein. (714 aa)
GAB1GRB2 associated binding protein 1. (748 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
SASH1SAM and SH3 domain containing 1. (1192 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (681 aa)
STIM1SAM domain-containing protein. (742 aa)
CCBE1Collagen and calcium binding EGF domains 1. (329 aa)
ISL1Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
LRG1LRRCT domain-containing protein. (361 aa)
CD40Uncharacterized protein. (299 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
GREM1Gremlin-1; Cytokine that may play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling. (184 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa)
GATA2GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (466 aa)
APLNRApelin receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
JUPPlakoglobin. (747 aa)
FLT1Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the c [...] (1327 aa)
CHRNA8Alpha8 subunit of nicotinic acetylcholine receptor. (511 aa)
EPHA1Uncharacterized protein. (969 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
C3AR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (461 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (586 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1140 aa)
HMGA2High mobility group protein I-C. (109 aa)
THBS1Uncharacterized protein. (1175 aa)
DDAH1Uncharacterized protein. (322 aa)
VEGFRKDRLUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1316 aa)
JCADJunctional cadherin 5 associated. (1325 aa)
XBP1BZIP domain-containing protein. (372 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa)
AGGF1Uncharacterized protein. (701 aa)
MYDGFUncharacterized protein. (167 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub- subfamily. (502 aa)
BRCA1Uncharacterized protein. (1749 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
CD34CD34 molecule. (385 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (781 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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