(54 nodes) Regulation of smooth muscle cell proliferation network (Gallus gallus)

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Predicted Interactions

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Your Input:
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (781 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
	HBEGF	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...] (212 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (144 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	MMP2	72 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa)
	GPER1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (762 aa)
	ADIPOQ	C1q domain-containing protein. (244 aa)
	VIPR2	VPAC2 receptor; Belongs to the G-protein coupled receptor 2 family. (439 aa)
	APOD	Apolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
	DDR1	Uncharacterized protein. (873 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	IL12A	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (203 aa)
	THBS1	Uncharacterized protein. (1175 aa)
	FRS2	IRS-type PTB domain-containing protein. (508 aa)
	EREG	EGF-like domain-containing protein. (153 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
	MNAT1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
	EDN1	Endothelin 1. (194 aa)
	VIP	Intestinal peptide PHI-27-like; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (200 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (269 aa)
	CX3CL1	SCY domain-containing protein. (496 aa)
	NDRG4	NDRG family member 4. (593 aa)
	PDGFRB	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1073 aa)
	CTNNB1	Uncharacterized protein. (781 aa)
	MEF2D	MADS-box domain-containing protein. (570 aa)
	TNFAIP3	TNF alpha induced protein 3. (806 aa)
	DBH	Dopamine beta-hydroxylase. (584 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (901 aa)
	RBPMS2	RNA-binding protein with multiple splicing 2; RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells. (200 aa)
	PPARGC1A	RRM domain-containing protein. (795 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	IL6R	Uncharacterized protein. (445 aa)
	NPR3	Natriuretic peptide receptor 3. (521 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
	WISP1	Uncharacterized protein. (359 aa)
	NDRG1	N-myc downstream regulated 1. (402 aa)
	ENSGALP00000067656	Uncharacterized protein. (174 aa)
	CALCRL	Calcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family. (457 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (514 aa)
	XRCC5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (711 aa)
	GNA12	G protein subunit alpha 12. (287 aa)
	MMP9	Uncharacterized protein. (713 aa)
	MYOCD	Phosphatase and actin regulator. (908 aa)
	APLN	Apelin. (78 aa)
	ENSGALP00000069991	Uncharacterized protein. (109 aa)
	P2RY6	P2Y purinoceptor 3; Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (328 aa)
	CTNNBIP1	ICAT domain-containing protein. (81 aa)
	ENSGALP00000073670	Uncharacterized protein. (184 aa)
	S1PR2	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	GJA1	Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles. Belongs to the connexin family. Alpha-type (group II) subfamily. (381 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APLN	ENSGALP00000008899	ENSGALP00000069961	C1q domain-containing protein.	Apelin.	0.612
ADIPOQ	IL10	ENSGALP00000008899	ENSGALP00000001310	C1q domain-containing protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.672
ADIPOQ	IL6	ENSGALP00000008899	ENSGALP00000068117	C1q domain-containing protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.866
ADIPOQ	PPARGC1A	ENSGALP00000008899	ENSGALP00000054176	C1q domain-containing protein.	RRM domain-containing protein.	0.692
APLN	ADIPOQ	ENSGALP00000069961	ENSGALP00000008899	Apelin.	C1q domain-containing protein.	0.612
APLN	GPER1	ENSGALP00000069961	ENSGALP00000006455	Apelin.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.543
APLN	PDGFB	ENSGALP00000069961	ENSGALP00000019858	Apelin.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.496
CTNNB1	CTNNBIP1	ENSGALP00000045406	ENSGALP00000072411	Uncharacterized protein.	ICAT domain-containing protein.	0.999
CTNNB1	GJA1	ENSGALP00000045406	ENSGALP00000073930	Uncharacterized protein.	Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles. Belongs to the connexin family. Alpha-type (group II) subfamily.	0.539
CTNNB1	IL6	ENSGALP00000045406	ENSGALP00000068117	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.454
CTNNB1	MEF2D	ENSGALP00000045406	ENSGALP00000045472	Uncharacterized protein.	MADS-box domain-containing protein.	0.553
CTNNB1	MMP9	ENSGALP00000045406	ENSGALP00000068659	Uncharacterized protein.	Uncharacterized protein.	0.513
CTNNB1	PIK3CA	ENSGALP00000045406	ENSGALP00000014504	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.621
CTNNBIP1	CTNNB1	ENSGALP00000072411	ENSGALP00000045406	ICAT domain-containing protein.	Uncharacterized protein.	0.999
CX3CL1	IL10	ENSGALP00000041151	ENSGALP00000001310	SCY domain-containing protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.563
CX3CL1	IL6	ENSGALP00000041151	ENSGALP00000068117	SCY domain-containing protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.594
CX3CL1	PIK3CA	ENSGALP00000041151	ENSGALP00000014504	SCY domain-containing protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.499
DDR2	PDGFRB	ENSGALP00000050290	ENSGALP00000043875	Discoidin domain receptor tyrosine kinase 2.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.473
EDN1	GJA1	ENSGALP00000020756	ENSGALP00000073930	Endothelin 1.	Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles. Belongs to the connexin family. Alpha-type (group II) subfamily.	0.450
EDN1	IL6	ENSGALP00000020756	ENSGALP00000068117	Endothelin 1.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.623