(48 nodes) Positive regulation of inflammatory response network (Gallus gallus)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	GPR68	G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	KARS	Lysine--tRNA ligase. (590 aa)
	C2CD4C	C2 calcium dependent domain containing 4C. (413 aa)
	IFI35	Interferon induced protein 35. (379 aa)
	TRADD	TNFRSF1A associated via death domain. (461 aa)
	LGALS2	Galectin. (131 aa)
	C2CD4A	C2 domain-containing protein. (431 aa)
	OSMR	Uncharacterized protein. (622 aa)
	TNIP1	TNFAIP3 interacting protein 1. (614 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1454 aa)
	IL18	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
	CEBPB	CCAAT/enhancer-binding protein beta; Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates [...] (328 aa)
	NAPEPLD	Lactamase_B domain-containing protein. (463 aa)
	STAP1	Signal transducing adaptor family member 1. (293 aa)
	SNX4	Sorting nexin 4. (435 aa)
	CG-1B	Beta-galactoside-binding lectin; This protein binds beta-galactoside. May participate in host antiviral defense through specific interaction with glycans on the viral envelope glycoproteins. (135 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	IL6ST	Glycoprotein 130. (918 aa)
	NFKBIZ	ANK_REP_REGION domain-containing protein. (618 aa)
	SETD4	SET domain-containing protein. (439 aa)
	CTSC	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (532 aa)
	ADORA2B	Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (340 aa)
	IL1RL1	Uncharacterized protein. (532 aa)
	CD47	CD47 glycoprotein isoform A. (317 aa)
	APP	BPTI/Kunitz inhibitor domain-containing protein. (751 aa)
	RIPK1	Uncharacterized protein. (682 aa)
	TNFSF11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
	CX3CL1	SCY domain-containing protein. (496 aa)
	IL8L2	Interleukin-8; May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils. (103 aa)
	CG-16	16 kDa beta-galactoside-binding lectin; This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation. (126 aa)
	IL18R1	Uncharacterized protein. (514 aa)
	CCR7	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	PARK7	Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] (189 aa)
	TNFRSF1A	Uncharacterized protein. (427 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	LRRK2	Uncharacterized protein. (2557 aa)
	WISP1	Uncharacterized protein. (359 aa)
	CAMK2N1	Calcium/calmodulin dependent protein kinase II inhibitor 1. (77 aa)
	NMI	N-myc and STAT interactor. (381 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (656 aa)
	PTGER4	Prostaglandin E2 receptor subtype 4; Belongs to the G-protein coupled receptor 1 family. (475 aa)
	TTBK1	Protein kinase domain-containing protein. (1419 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	FFAR2L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	SUCNR1	Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (317 aa)
	TAFA3	TAFA chemokine like family member 3. (136 aa)
	LOC107050658	Free fatty acid receptor 2-like. (367 aa)
	IL17RA	SEFIR domain-containing protein. (978 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA2B	PTGER4	ENSGALP00000027991	ENSGALP00000065250	Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin E2 receptor subtype 4; Belongs to the G-protein coupled receptor 1 family.	0.417
APP	CG-16	ENSGALP00000036014	ENSGALP00000044554	BPTI/Kunitz inhibitor domain-containing protein.	16 kDa beta-galactoside-binding lectin; This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation.	0.400
APP	CG-1B	ENSGALP00000036014	ENSGALP00000020275	BPTI/Kunitz inhibitor domain-containing protein.	Beta-galactoside-binding lectin; This protein binds beta-galactoside. May participate in host antiviral defense through specific interaction with glycans on the viral envelope glycoproteins.	0.410
APP	CX3CL1	ENSGALP00000036014	ENSGALP00000041151	BPTI/Kunitz inhibitor domain-containing protein.	SCY domain-containing protein.	0.546
APP	IL1B	ENSGALP00000036014	ENSGALP00000050171	BPTI/Kunitz inhibitor domain-containing protein.	Interleukin-1; Belongs to the IL-1 family.	0.490
APP	IL6	ENSGALP00000036014	ENSGALP00000068117	BPTI/Kunitz inhibitor domain-containing protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.454
CCR7	CX3CL1	ENSGALP00000048400	ENSGALP00000041151	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.705
CCR7	IL18	ENSGALP00000048400	ENSGALP00000012772	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.479
CCR7	IL1B	ENSGALP00000048400	ENSGALP00000050171	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-1; Belongs to the IL-1 family.	0.660
CCR7	IL6	ENSGALP00000048400	ENSGALP00000068117	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.752
CCR7	IL8L2	ENSGALP00000048400	ENSGALP00000041738	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-8; May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils.	0.509
CCR7	TLR3	ENSGALP00000048400	ENSGALP00000021914	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.435
CD47	CG-16	ENSGALP00000029799	ENSGALP00000044554	CD47 glycoprotein isoform A.	16 kDa beta-galactoside-binding lectin; This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation.	0.485
CD47	CG-1B	ENSGALP00000029799	ENSGALP00000020275	CD47 glycoprotein isoform A.	Beta-galactoside-binding lectin; This protein binds beta-galactoside. May participate in host antiviral defense through specific interaction with glycans on the viral envelope glycoproteins.	0.484
CEBPB	IL1B	ENSGALP00000012991	ENSGALP00000050171	CCAAT/enhancer-binding protein beta; Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates [...]	Interleukin-1; Belongs to the IL-1 family.	0.623
CEBPB	IL6	ENSGALP00000012991	ENSGALP00000068117	CCAAT/enhancer-binding protein beta; Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates [...]	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.646
CG-16	APP	ENSGALP00000044554	ENSGALP00000036014	16 kDa beta-galactoside-binding lectin; This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation.	BPTI/Kunitz inhibitor domain-containing protein.	0.400
CG-16	CD47	ENSGALP00000044554	ENSGALP00000029799	16 kDa beta-galactoside-binding lectin; This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation.	CD47 glycoprotein isoform A.	0.485
CG-16	IL1B	ENSGALP00000044554	ENSGALP00000050171	16 kDa beta-galactoside-binding lectin; This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation.	Interleukin-1; Belongs to the IL-1 family.	0.417
CG-16	IL6	ENSGALP00000044554	ENSGALP00000068117	16 kDa beta-galactoside-binding lectin; This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.450