STRINGSTRING
SMTNL2 SMTNL2 MYOM1 MYOM1 CHORDC1 CHORDC1 FHL3 FHL3 IGFN1 IGFN1 MYH1A MYH1A CAPZA2 CAPZA2 CAPZA1 CAPZA1 TRIM54 TRIM54 TMOD2 TMOD2 MYZAP MYZAP LRRC10B LRRC10B MYOZ2 MYOZ2 MYH1B MYH1B TNNT3 TNNT3 KY KY SYNC SYNC ENSGALP00000065325 ENSGALP00000065325 NEBL1 NEBL1 EVA1C EVA1C ENSGALP00000065886 ENSGALP00000065886 SPTAN1 SPTAN1 ENSGALP00000066473 ENSGALP00000066473 FBXL22 FBXL22 AHNAK2 AHNAK2 FHL5 FHL5 TRIM63 TRIM63 ITGB1BP2 ITGB1BP2 MYBPC2 MYBPC2 MYOZ3 MYOZ3 C7orf57 C7orf57 ADPRHL ADPRHL PPP1R12C PPP1R12C PPP1R12B PPP1R12B MYL4 MYL4 MYH1G MYH1G TNNC1 TNNC1 TMOD1 TMOD1 UNC45B UNC45B SPHKAP SPHKAP MTMR12 MTMR12 MYPN MYPN CSRP3 CSRP3 MYOM3 MYOM3 TMOD3 TMOD3 VCL VCL LRRC39 LRRC39 KLHL40 KLHL40 ANKRD1 ANKRD1 TNNI2 TNNI2 TNNC2 TNNC2 KCTD6 KCTD6 ANKRD2 ANKRD2 TTC12 TTC12 LMOD2 LMOD2 NEXN NEXN SRI SRI MTM1 MTM1 PPP1R12A PPP1R12A ASB2 ASB2 CAPN9 CAPN9 DES DES SYNPO2 SYNPO2 PYROXD1 PYROXD1 PDLIM3 PDLIM3 LRRC2 LRRC2 MYOM2 MYOM2 ADPRHL1 ADPRHL1 LMOD3 LMOD3 ADPRH ADPRH SYNM SYNM MYL2 MYL2 MYH15 MYH15 MYBPC1 MYBPC1 IGDCC3 IGDCC3 MYBPHL MYBPHL R4GGX0_CHICK R4GGX0_CHICK LMOD1 LMOD1 EVA1A EVA1A ENSGALP00000073678 ENSGALP00000073678 ENSGALP00000073668 ENSGALP00000073668 TNNI1 TNNI1 ROBO2 ROBO2 ENSGALP00000072279 ENSGALP00000072279 TMOD4 TMOD4 PRRC2B PRRC2B ENSGALP00000070799 ENSGALP00000070799 SMPX SMPX TXLNB TXLNB SVIL SVIL LRRC10 LRRC10 ENSGALP00000068828 ENSGALP00000068828 UNC45A UNC45A MYH1D MYH1D CMYA5 CMYA5 CAVIN4 CAVIN4 MYL3 MYL3 MYOT MYOT PDLIM1 PDLIM1 ENSGALP00000044688 ENSGALP00000044688 GGPS1 GGPS1 TRIM55 TRIM55 MYO7L2 MYO7L2 MYH1E MYH1E TNNT1 TNNT1 MYH7B MYH7B CCDC102A CCDC102A KLHL41 KLHL41 FHL2 FHL2 MYH11 MYH11 MYH1C MYH1C MYH7 MYH7 MYH1F MYH1F ILK ILK LDB3 LDB3 TMEFF1 TMEFF1 TNNT2 TNNT2 LRRC30 LRRC30 ENSGALP00000051466 ENSGALP00000051466 MYL10 MYL10 ACTA1 ACTA1 MYBPC3 MYBPC3 CAPN3 CAPN3 ACTN2 ACTN2 SYNPO2L SYNPO2L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMTNL2Smoothelin like 2. (468 aa)
MYOM1Uncharacterized protein. (1671 aa)
CHORDC1Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication. (331 aa)
FHL3Four and a half LIM domains 3. (279 aa)
IGFN1Uncharacterized protein. (2363 aa)
MYH1AUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
CAPZA2F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line. (286 aa)
CAPZA1F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. (286 aa)
TRIM54Tripartite motif containing 54. (377 aa)
TMOD2Tropomodulin 2. (351 aa)
MYZAPUncharacterized protein. (588 aa)
LRRC10BLeucine rich repeat containing 10B. (269 aa)
MYOZ2Uncharacterized protein. (263 aa)
MYH1BMyosin-1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1944 aa)
TNNT3Troponin T, fast skeletal muscle isoforms; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (220 aa)
KYTGc domain-containing protein. (684 aa)
SYNCSyncoilin, intermediate filament protein. (672 aa)
ENSGALP00000065325Uncharacterized protein. (485 aa)
NEBL1Uncharacterized protein. (2613 aa)
EVA1CEva-1 homolog C. (435 aa)
ENSGALP00000065886Uncharacterized protein. (123 aa)
SPTAN1Spectrin alpha chain, non-erythrocytic 1; Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization. (2497 aa)
ENSGALP00000066473Uncharacterized protein. (262 aa)
FBXL22F-box and leucine rich repeat protein 22. (226 aa)
AHNAK2PDZ domain-containing protein. (4209 aa)
FHL5Uncharacterized protein. (303 aa)
TRIM63Tripartite motif containing 63. (509 aa)
ITGB1BP2Integrin subunit beta 1 binding protein 2. (547 aa)
MYBPC2Myosin-binding protein C, fast-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. (254 aa)
MYOZ3Myozenin 3. (241 aa)
C7orf57Chromosome 7 open reading frame 57. (256 aa)
ADPRHLUncharacterized protein. (532 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (855 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1047 aa)
MYL4Myosin light chain, embryonic. (185 aa)
MYH1GUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (215 aa)
TMOD1Uncharacterized protein. (359 aa)
UNC45BUnc-45 myosin chaperone B. (929 aa)
SPHKAPAKAP_110 domain-containing protein. (1672 aa)
MTMR12Myotubularin related protein 12. (737 aa)
MYPNMyopalladin. (991 aa)
CSRP3Uncharacterized protein. (194 aa)
MYOM3Myomesin 3. (1373 aa)
TMOD3Uncharacterized protein. (352 aa)
VCLVinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
LRRC39Leucine rich repeat containing 39. (342 aa)
KLHL40Kelch like family member 40. (587 aa)
ANKRD1Ankyrin repeat domain-containing protein 1; May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. (319 aa)
TNNI2Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (183 aa)
TNNC2Troponin C, skeletal muscle; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (163 aa)
KCTD6Potassium channel tetramerization domain containing 6. (237 aa)
ANKRD2Ankyrin repeat domain 2 protein. (334 aa)
TTC12TPR_REGION domain-containing protein. (707 aa)
LMOD2Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function (By similarity); Belongs to the tropomodulin family. (552 aa)
NEXNNexilin F-actin binding protein. (612 aa)
SRIUncharacterized protein. (297 aa)
MTM1Myotubularin 1. (603 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1084 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (645 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (881 aa)
DESDesmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. (464 aa)
SYNPO2Synaptopodin 2. (1272 aa)
PYROXD1Uncharacterized protein. (500 aa)
PDLIM3PDZ and LIM domain protein 3. (363 aa)
LRRC2Leucine rich repeat containing 2. (372 aa)
MYOM2M-protein, striated muscle; Is a structural constituent of myofibrillar M-band in striated muscle. (1450 aa)
ADPRHL1Uncharacterized protein. (218 aa)
LMOD3Leiomodin 3. (524 aa)
ADPRHUncharacterized protein. (384 aa)
SYNMIF rod domain-containing protein; Belongs to the intermediate filament family. (1604 aa)
MYL2Myosin regulatory light chain 2A, cardiac muscle isoform. (202 aa)
MYH15Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
MYBPC1Myosin binding protein C, slow type. (1227 aa)
IGDCC3Immunoglobulin superfamily DCC subclass member 3. (773 aa)
MYBPHLMyosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Belongs to the immunoglobulin superfamily. MyBP family. (537 aa)
R4GGX0_CHICKUncharacterized protein. (484 aa)
LMOD1Leiomodin 1. (624 aa)
EVA1AUncharacterized protein. (478 aa)
ENSGALP00000073678Uncharacterized protein. (419 aa)
ENSGALP00000073668Myosin_tail_1 domain-containing protein. (254 aa)
TNNI1Troponin I1, slow skeletal type. (189 aa)
ROBO2Roundabout guidance receptor 2. (1400 aa)
ENSGALP00000072279Cnn_1N domain-containing protein. (161 aa)
TMOD4Uncharacterized protein. (570 aa)
PRRC2BProline rich coiled-coil 2B. (2227 aa)
ENSGALP00000070799SH3 domain-containing protein. (249 aa)
SMPXUncharacterized protein. (88 aa)
TXLNBBeta-taxilin; Promotes neurite-outgrowth. May be involved in intracellular vesicle traffic. (693 aa)
SVILSupervillin. (2303 aa)
LRRC10Leucine rich repeat containing 10. (248 aa)
ENSGALP00000068828Uncharacterized protein. (185 aa)
UNC45AUnc-45 myosin chaperone A. (974 aa)
MYH1DMyosin-1B; Muscle contraction. (1940 aa)
CMYA5Uncharacterized protein. (4413 aa)
CAVIN4Caveolae associated protein 4. (357 aa)
MYL3Myosin light chain 1, cardiac muscle. (194 aa)
MYOTMyotilin. (513 aa)
PDLIM1PDZ and LIM domain 1. (340 aa)
ENSGALP00000044688Myosin_tail_1 domain-containing protein. (234 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (299 aa)
TRIM55Uncharacterized protein. (443 aa)
MYO7L2Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1743 aa)
MYH1EMyosin heavy chain, skeletal muscle, adult; Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. (1939 aa)
TNNT1Uncharacterized protein. (272 aa)
MYH7BUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
CCDC102ACoiled-coil domain containing 102A. (540 aa)
KLHL41Kelch like family member 41. (606 aa)
FHL2Four and a half LIM domains 2. (279 aa)
MYH11Myosin-11; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1978 aa)
MYH1CUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
MYH7Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1931 aa)
MYH1FUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
ILKIntegrin-linked kinase. (452 aa)
LDB3PDZ domain-containing protein. (283 aa)
TMEFF1Uncharacterized protein. (362 aa)
TNNT2Troponin T, cardiac muscle isoforms; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (302 aa)
LRRC30Uncharacterized protein. (298 aa)
ENSGALP00000051466Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (462 aa)
MYL10Myosin regulatory light chain 2B, cardiac muscle isoform. (187 aa)
ACTA1Actin, alpha skeletal muscle. (390 aa)
MYBPC3Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle A bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. May be involved in the early phase of myofibrillogenesis; Belongs to the immunoglobulin superfamily. MyBP family. (1285 aa)
CAPN3Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (810 aa)
ACTN2Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (923 aa)
SYNPO2LSynaptopodin 2 like. (1080 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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