(14 nodes) Small GTPase Rho network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	RND2	Uncharacterized protein. (227 aa)
	RHOC	Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). (193 aa)
	RHOT2	Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa)
	RHOT1	Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa)
	RHOGL	Uncharacterized protein. (191 aa)
	RAC1	GTPase cRac1A. (192 aa)
	RHOB	GTP-binding protein. (196 aa)
	RHOA	GTP-binding protein. (193 aa)
	RAC2	Uncharacterized protein. (192 aa)
	RHOV	Ras homolog family member V. (231 aa)
	RHOG	Ras homolog family member G. (348 aa)
	RAC3	GTPase cRac1B. (192 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
	RHOH	Ras homolog family member H. (191 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	RAC1	ENSGALP00000065867	ENSGALP00000011538	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	GTPase cRac1A.	0.798
CDC42	RAC2	ENSGALP00000065867	ENSGALP00000037001	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	Uncharacterized protein.	0.640
CDC42	RAC3	ENSGALP00000065867	ENSGALP00000045177	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	GTPase cRac1B.	0.633
CDC42	RHOA	ENSGALP00000065867	ENSGALP00000033584	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	GTP-binding protein.	0.477
CDC42	RHOG	ENSGALP00000065867	ENSGALP00000043362	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	Ras homolog family member G.	0.539
CDC42	RHOV	ENSGALP00000065867	ENSGALP00000042743	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	Ras homolog family member V.	0.526
RAC1	CDC42	ENSGALP00000011538	ENSGALP00000065867	GTPase cRac1A.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	0.798
RAC1	RAC2	ENSGALP00000011538	ENSGALP00000037001	GTPase cRac1A.	Uncharacterized protein.	0.901
RAC1	RAC3	ENSGALP00000011538	ENSGALP00000045177	GTPase cRac1A.	GTPase cRac1B.	0.901
RAC1	RHOA	ENSGALP00000011538	ENSGALP00000033584	GTPase cRac1A.	GTP-binding protein.	0.933
RAC1	RHOB	ENSGALP00000011538	ENSGALP00000026544	GTPase cRac1A.	GTP-binding protein.	0.648
RAC1	RHOC	ENSGALP00000011538	ENSGALP00000002383	GTPase cRac1A.	Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity).	0.660
RAC1	RHOG	ENSGALP00000011538	ENSGALP00000043362	GTPase cRac1A.	Ras homolog family member G.	0.472
RAC2	CDC42	ENSGALP00000037001	ENSGALP00000065867	Uncharacterized protein.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	0.640
RAC2	RAC1	ENSGALP00000037001	ENSGALP00000011538	Uncharacterized protein.	GTPase cRac1A.	0.901
RAC2	RAC3	ENSGALP00000037001	ENSGALP00000045177	Uncharacterized protein.	GTPase cRac1B.	0.901
RAC2	RHOA	ENSGALP00000037001	ENSGALP00000033584	Uncharacterized protein.	GTP-binding protein.	0.928
RAC2	RHOG	ENSGALP00000037001	ENSGALP00000043362	Uncharacterized protein.	Ras homolog family member G.	0.683
RAC3	CDC42	ENSGALP00000045177	ENSGALP00000065867	GTPase cRac1B.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	0.633
RAC3	RAC1	ENSGALP00000045177	ENSGALP00000011538	GTPase cRac1B.	GTPase cRac1A.	0.901