(11 nodes) Toll/interleukin-1 receptor homology (TIR) domain superfamily network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1; Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3- kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll- like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival o [...] (800 aa)
	ENSGALP00000071814	TIR domain-containing protein. (149 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1059 aa)
	TLR1B	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family. (652 aa)
	TLR2A	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
	TLR2B	Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	TLR5	TLR5; Belongs to the Toll-like receptor family. (861 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	IL17RD	Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). (741 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MYD88	TLR1B	ENSGALP00000042597	ENSGALP00000067827	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family.	0.895
MYD88	TLR2A	ENSGALP00000042597	ENSGALP00000050968	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.999
MYD88	TLR2B	ENSGALP00000042597	ENSGALP00000038134	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.995
MYD88	TLR3	ENSGALP00000042597	ENSGALP00000021914	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.995
MYD88	TLR4	ENSGALP00000042597	ENSGALP00000011319	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.999
MYD88	TLR5	ENSGALP00000042597	ENSGALP00000015286	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TLR5; Belongs to the Toll-like receptor family.	0.995
MYD88	TLR7	ENSGALP00000042597	ENSGALP00000070844	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.998
TLR1B	MYD88	ENSGALP00000067827	ENSGALP00000042597	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.895
TLR1B	TLR2A	ENSGALP00000067827	ENSGALP00000050968	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family.	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.997
TLR1B	TLR2B	ENSGALP00000067827	ENSGALP00000038134	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family.	Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.992
TLR1B	TLR3	ENSGALP00000067827	ENSGALP00000021914	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.454
TLR1B	TLR4	ENSGALP00000067827	ENSGALP00000011319	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.735
TLR1B	TLR5	ENSGALP00000067827	ENSGALP00000015286	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family.	TLR5; Belongs to the Toll-like receptor family.	0.595
TLR1B	TLR7	ENSGALP00000067827	ENSGALP00000070844	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.563
TLR2A	MYD88	ENSGALP00000050968	ENSGALP00000042597	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.999
TLR2A	TLR1B	ENSGALP00000050968	ENSGALP00000067827	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family.	0.997
TLR2A	TLR3	ENSGALP00000050968	ENSGALP00000021914	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.479
TLR2A	TLR4	ENSGALP00000050968	ENSGALP00000011319	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.738
TLR2A	TLR5	ENSGALP00000050968	ENSGALP00000015286	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	TLR5; Belongs to the Toll-like receptor family.	0.643
TLR2A	TLR7	ENSGALP00000050968	ENSGALP00000070844	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.501