(15 nodes) (2018) New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes. network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KIFC3	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (834 aa)
	POR	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (676 aa)
	TRAK2	Trafficking kinesin protein 2. (901 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (613 aa)
	ACOX3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (706 aa)
	ACBD5	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family. (503 aa)
	PEX13	SH3 domain-containing protein. (397 aa)
	VAPB	MSP domain-containing protein. (243 aa)
	CTSD	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL. (398 aa)
	RHOT1	Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa)
	RHOT2	Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa)
	ACOX1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (662 aa)
	VAPA	MSP domain-containing protein. (284 aa)
	PEX14	Peroxisomal biogenesis factor 14. (363 aa)
	TRAK1	Trafficking kinesin protein 1. (1048 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACBD5	ACOX1	ENSGALP00000053041	ENSGALP00000003376	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.690
ACBD5	ACOX3	ENSGALP00000053041	ENSGALP00000025093	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.611
ACBD5	PEX13	ENSGALP00000053041	ENSGALP00000012694	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family.	SH3 domain-containing protein.	0.639
ACBD5	PEX14	ENSGALP00000053041	ENSGALP00000061647	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family.	Peroxisomal biogenesis factor 14.	0.920
ACBD5	RHOT1	ENSGALP00000053041	ENSGALP00000005362	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family.	Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).	0.542
ACBD5	TRAK2	ENSGALP00000053041	ENSGALP00000013618	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family.	Trafficking kinesin protein 2.	0.585
ACBD5	VAPA	ENSGALP00000053041	ENSGALP00000055161	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family.	MSP domain-containing protein.	0.855
ACBD5	VAPB	ENSGALP00000053041	ENSGALP00000012193	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family.	MSP domain-containing protein.	0.850
ACOX1	ACBD5	ENSGALP00000003376	ENSGALP00000053041	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family.	0.690
ACOX1	ACOX3	ENSGALP00000003376	ENSGALP00000025093	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.931
ACOX1	PEX13	ENSGALP00000003376	ENSGALP00000012694	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	SH3 domain-containing protein.	0.800
ACOX1	PEX14	ENSGALP00000003376	ENSGALP00000061647	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Peroxisomal biogenesis factor 14.	0.869
ACOX1	POR	ENSGALP00000003376	ENSGALP00000072561	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.496
ACOX3	ACBD5	ENSGALP00000025093	ENSGALP00000053041	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family.	0.611
ACOX3	ACOX1	ENSGALP00000025093	ENSGALP00000003376	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.931
ACOX3	PEX13	ENSGALP00000025093	ENSGALP00000012694	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	SH3 domain-containing protein.	0.795
ACOX3	PEX14	ENSGALP00000025093	ENSGALP00000061647	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	Peroxisomal biogenesis factor 14.	0.853
ACOX3	POR	ENSGALP00000025093	ENSGALP00000072561	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.506
KIFC3	PEX14	ENSGALP00000071790	ENSGALP00000061647	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Peroxisomal biogenesis factor 14.	0.502
PEX13	ACBD5	ENSGALP00000012694	ENSGALP00000053041	SH3 domain-containing protein.	Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family.	0.639