(16 nodes) (2022) Mitochondrial Alterations in Neurons Derived from the Murine AppNL-F Knock-In Model of Alzheimers Disease. network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGALP00000070006	Synaptophysin. (351 aa)
	TRAK1	Trafficking kinesin protein 1. (1048 aa)
	PSEN1	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
	BACE1	Beta-secretase 1; Belongs to the peptidase A1 family. (497 aa)
	MCU	Mitochondrial calcium uniporter. (344 aa)
	VDAC1	Uncharacterized protein. (307 aa)
	NCSTN	Ncstrn_small domain-containing protein. (717 aa)
	SNAP25	Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity). Belongs to the SNAP-25 family. (206 aa)
	TRAK2	Trafficking kinesin protein 2. (901 aa)
	VAPB	MSP domain-containing protein. (243 aa)
	SYP	MARVEL domain-containing protein. (338 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (762 aa)
	RHOT1	Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa)
	ADAM10	Uncharacterized protein. (749 aa)
	RHOT2	Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa)
	MAPT	Microtubule-associated protein. (788 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	BACE1	ENSGALP00000006687	ENSGALP00000055878	Uncharacterized protein.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.785
ADAM10	NCSTN	ENSGALP00000006687	ENSGALP00000014876	Uncharacterized protein.	Ncstrn_small domain-containing protein.	0.860
ADAM10	PSEN1	ENSGALP00000006687	ENSGALP00000069770	Uncharacterized protein.	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family.	0.822
BACE1	ADAM10	ENSGALP00000055878	ENSGALP00000006687	Beta-secretase 1; Belongs to the peptidase A1 family.	Uncharacterized protein.	0.785
BACE1	ENSGALP00000070006	ENSGALP00000055878	ENSGALP00000070006	Beta-secretase 1; Belongs to the peptidase A1 family.	Synaptophysin.	0.508
BACE1	MAPT	ENSGALP00000055878	ENSGALP00000072691	Beta-secretase 1; Belongs to the peptidase A1 family.	Microtubule-associated protein.	0.472
BACE1	NCSTN	ENSGALP00000055878	ENSGALP00000014876	Beta-secretase 1; Belongs to the peptidase A1 family.	Ncstrn_small domain-containing protein.	0.806
BACE1	PSEN1	ENSGALP00000055878	ENSGALP00000069770	Beta-secretase 1; Belongs to the peptidase A1 family.	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family.	0.823
BACE1	SYP	ENSGALP00000055878	ENSGALP00000011785	Beta-secretase 1; Belongs to the peptidase A1 family.	MARVEL domain-containing protein.	0.489
ENSGALP00000070006	BACE1	ENSGALP00000070006	ENSGALP00000055878	Synaptophysin.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.508
ENSGALP00000070006	MAPT	ENSGALP00000070006	ENSGALP00000072691	Synaptophysin.	Microtubule-associated protein.	0.459
ENSGALP00000070006	PSEN1	ENSGALP00000070006	ENSGALP00000069770	Synaptophysin.	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family.	0.638
ENSGALP00000070006	SNAP25	ENSGALP00000070006	ENSGALP00000014636	Synaptophysin.	Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity). Belongs to the SNAP-25 family.	0.856
MAPT	BACE1	ENSGALP00000072691	ENSGALP00000055878	Microtubule-associated protein.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.472
MAPT	ENSGALP00000070006	ENSGALP00000072691	ENSGALP00000070006	Microtubule-associated protein.	Synaptophysin.	0.459
MAPT	PSEN1	ENSGALP00000072691	ENSGALP00000069770	Microtubule-associated protein.	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family.	0.812
MAPT	SYP	ENSGALP00000072691	ENSGALP00000011785	Microtubule-associated protein.	MARVEL domain-containing protein.	0.461
MAPT	VDAC1	ENSGALP00000072691	ENSGALP00000043741	Microtubule-associated protein.	Uncharacterized protein.	0.645
MCU	MFN2	ENSGALP00000049377	ENSGALP00000007187	Mitochondrial calcium uniporter.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.785
MCU	VAPB	ENSGALP00000049377	ENSGALP00000012193	Mitochondrial calcium uniporter.	MSP domain-containing protein.	0.545