(12 nodes) (2023) Echinacea purpurea (L.) Moench Polysaccharide Alleviates DSS-Induced Colitis in Rats by Restoring Th17Treg Balance and Regulating Intestinal Flora. network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	IL22	Uncharacterized protein. (197 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
	STAT3	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	PXDN	Peroxidasin. (1611 aa)
	IL17A	Uncharacterized protein. (169 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
	FOXP1	Forkhead box protein P1; Transcriptional repressor. (686 aa)
	PXDNL	Uncharacterized protein. (1406 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	CD4	Uncharacterized protein. (487 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	FOXP1	ENSGALP00000065611	ENSGALP00000044290	Uncharacterized protein.	Forkhead box protein P1; Transcriptional repressor.	0.979
CD4	IL10	ENSGALP00000065611	ENSGALP00000001310	Uncharacterized protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.982
CD4	IL17A	ENSGALP00000065611	ENSGALP00000026862	Uncharacterized protein.	Uncharacterized protein.	0.981
CD4	IL1B	ENSGALP00000065611	ENSGALP00000050171	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.957
CD4	IL22	ENSGALP00000065611	ENSGALP00000016087	Uncharacterized protein.	Uncharacterized protein.	0.877
CD4	IL6	ENSGALP00000065611	ENSGALP00000068117	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.982
CD4	MYD88	ENSGALP00000065611	ENSGALP00000042597	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.854
CD4	PXDN	ENSGALP00000065611	ENSGALP00000026363	Uncharacterized protein.	Peroxidasin.	0.790
CD4	PXDNL	ENSGALP00000065611	ENSGALP00000049777	Uncharacterized protein.	Uncharacterized protein.	0.790
CD4	STAT3	ENSGALP00000065611	ENSGALP00000005161	Uncharacterized protein.	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes.	0.848
CD4	TLR4	ENSGALP00000065611	ENSGALP00000011319	Uncharacterized protein.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.888
FOXP1	CD4	ENSGALP00000044290	ENSGALP00000065611	Forkhead box protein P1; Transcriptional repressor.	Uncharacterized protein.	0.979
FOXP1	IL10	ENSGALP00000044290	ENSGALP00000001310	Forkhead box protein P1; Transcriptional repressor.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.960
FOXP1	IL17A	ENSGALP00000044290	ENSGALP00000026862	Forkhead box protein P1; Transcriptional repressor.	Uncharacterized protein.	0.958
FOXP1	IL1B	ENSGALP00000044290	ENSGALP00000050171	Forkhead box protein P1; Transcriptional repressor.	Interleukin-1; Belongs to the IL-1 family.	0.747
FOXP1	IL22	ENSGALP00000044290	ENSGALP00000016087	Forkhead box protein P1; Transcriptional repressor.	Uncharacterized protein.	0.706
FOXP1	IL6	ENSGALP00000044290	ENSGALP00000068117	Forkhead box protein P1; Transcriptional repressor.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.855
FOXP1	MYD88	ENSGALP00000044290	ENSGALP00000042597	Forkhead box protein P1; Transcriptional repressor.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.600
FOXP1	PXDN	ENSGALP00000044290	ENSGALP00000026363	Forkhead box protein P1; Transcriptional repressor.	Peroxidasin.	0.499
FOXP1	PXDNL	ENSGALP00000044290	ENSGALP00000049777	Forkhead box protein P1; Transcriptional repressor.	Uncharacterized protein.	0.499