STRINGSTRING
CDK1 CDK1 RPA2 RPA2 CREB3L3 CREB3L3 CDC45 CDC45 E2F4 E2F4 CREB3 CREB3 E2F1 E2F1 RPA1 RPA1 CCND3 CCND3 CCNE1 CCNE1 MCM2 MCM2 CCND1 CCND1 ORC2 ORC2 CREB3L1 CREB3L1 CDK6 CDK6 MDM2 MDM2 CCNG2 CCNG2 CDKN2C CDKN2C ORC1 ORC1 RPA3 RPA3 MNAT1 MNAT1 ORC4 ORC4 MCM5 MCM5 MCM4 MCM4 CDK7 CDK7 ORC3 ORC3 PRIM2 PRIM2 MCM3 MCM3 TFDP1 TFDP1 CCNA1 CCNA1 ATM ATM CCND2 CCND2 E2F6 E2F6 MCM6 MCM6 CDKN1B CDKN1B E2F3 E2F3 GADD45A GADD45A WEE1 WEE1 CDKN2B CDKN2B CCNE2 CCNE2 PRIM1 PRIM1 E2F5 E2F5 POLE2 POLE2 TFDP2 TFDP2 CDK2 CDK2 MYT1 MYT1 CDC25A CDC25A CCNH CCNH PCNA PCNA RBL1 RBL1 RB1 RB1 CDKN1A CDKN1A MYC MYC ORC5 ORC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa)
RPA2RPA_C domain-containing protein. (267 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (493 aa)
CDC45Cell division cycle 45. (566 aa)
E2F4E2F transcription factor 4. (414 aa)
CREB3cAMP responsive element binding protein 3. (390 aa)
E2F1Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] (403 aa)
RPA1Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (614 aa)
CCND3Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
CCNE1G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. (407 aa)
MCM2DNA helicase; Belongs to the MCM family. (929 aa)
CCND1G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa)
ORC2Uncharacterized protein. (569 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (506 aa)
CDK6Cyclin-dependent kinase; Belongs to the protein kinase superfamily. (326 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa)
CCNG2Cyclin G2. (259 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (167 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (867 aa)
RPA3Replication protein A3. (121 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (530 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
MCM4DNA helicase; Belongs to the MCM family. (859 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
ORC3ORC_WH_C domain-containing protein. (713 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (508 aa)
MCM3DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa)
TFDP1Transcription factor. (411 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (406 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
CCND2G1/S-specific cyclin-D2; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin D subfamily. (291 aa)
E2F6E2F_TDP domain-containing protein. (252 aa)
MCM6DNA helicase; Belongs to the MCM family. (825 aa)
CDKN1BCyclin-dependent kinase inhibitor p27 Kip1. (198 aa)
E2F3E2F transcription factor 3. (341 aa)
GADD45AGrowth arrest and DNA-damage-inducible protein 45 alpha. (157 aa)
WEE1Wee1-like protein kinase. (641 aa)
CDKN2Bp15INK4b tumor suppressor. (139 aa)
CCNE2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (431 aa)
E2F5E2F_TDP domain-containing protein. (375 aa)
POLE2DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). (555 aa)
TFDP2Uncharacterized protein. (508 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
MYT1Myelin transcription factor 1. (1105 aa)
CDC25ARhodanese domain-containing protein. (526 aa)
CCNHCyclin H; Belongs to the cyclin family. (322 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
RBL1RB transcriptional corepressor like 1. (1050 aa)
RB1Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
CDKN1AUncharacterized protein. (319 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
ORC5AAA_16 domain-containing protein. (459 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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