STRINGSTRING
ITGB3 ITGB3 LAMB3 LAMB3 COMP COMP FN1 FN1 VTN VTN COL4A4 COL4A4 FREM1 FREM1 LAMB1 LAMB1 ITGA11 ITGA11 COL4A5 COL4A5 RELN RELN THBS1 THBS1 COL1A2 COL1A2 SPP1 SPP1 ITGB6 ITGB6 THBS4 THBS4 PELO PELO ITGA2 ITGA2 LAMA4 LAMA4 SDC1 SDC1 CD47 CD47 CHAD CHAD SV2C SV2C LAMA1 LAMA1 COL9A1 COL9A1 VWF VWF IBSP IBSP FRAS1 FRAS1 LAMC1 LAMC1 COL6A2 COL6A2 LAMA3 LAMA3 HMMR HMMR ITGAV ITGAV ITGB5 ITGB5 COL4A1 COL4A1 FREM2 FREM2 HSPG2 HSPG2 DAG1 DAG1 ITGA7 ITGA7 GP5 GP5 DMP1 DMP1 COL2A1 COL2A1 ITGA4 ITGA4 COL4A3 COL4A3 ITGB1 ITGB1 ITGA9 ITGA9 ITGA6 ITGA6 CD44 CD44 SV2B SV2B COL9A3 COL9A3 COL6A1 COL6A1 COL1A1 COL1A1 ITGB8 ITGB8 AGRN AGRN TNR TNR COL4A2 COL4A2 ITGA8 ITGA8 LAMA2 LAMA2 ITGA2B ITGA2B LAMB4 LAMB4 CD36 CD36 LOC101750889 LOC101750889 ENSGALP00000069232 ENSGALP00000069232 TNN TNN COL6A6 COL6A6 SDC4 SDC4 COL6A3 COL6A3 LAMC3 LAMC3 COL4A6 COL4A6 GP1BB GP1BB THBS2 THBS2 SV2A SV2A LAMA5 LAMA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB3Integrin beta; Belongs to the integrin beta chain family. (781 aa)
LAMB3Laminin subunit beta 3. (1168 aa)
COMPUncharacterized protein. (777 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa)
VTNSMB domain-containing protein. (453 aa)
COL4A4Collagen IV NC1 domain-containing protein. (1307 aa)
FREM1FRAS1 related extracellular matrix 1. (2184 aa)
LAMB1Laminin subunit beta-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1785 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1240 aa)
COL4A5Collagen IV NC1 domain-containing protein. (540 aa)
RELNReelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity); Belongs to the reel [...] (3462 aa)
THBS1Uncharacterized protein. (1175 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1363 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (264 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (789 aa)
THBS4Uncharacterized protein. (953 aa)
PELOIntegrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). (1175 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1175 aa)
LAMA4Laminin subunit alpha 4. (1827 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (308 aa)
CD47CD47 glycoprotein isoform A. (317 aa)
CHADUncharacterized protein. (361 aa)
SV2CSynaptic vesicle glycoprotein 2C. (727 aa)
LAMA1Uncharacterized protein. (3091 aa)
COL9A1Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (920 aa)
VWFUncharacterized protein. (2800 aa)
IBSPBone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). (200 aa)
FRAS1Uncharacterized protein. (3989 aa)
LAMC1Laminin subunit gamma 1. (1603 aa)
COL6A2Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. (1022 aa)
LAMA3Laminin subunit alpha 3. (3448 aa)
HMMRHyaluronan mediated motility receptor. (728 aa)
ITGAVIntegrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] (1048 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (811 aa)
COL4A1Collagen IV NC1 domain-containing protein. (1669 aa)
FREM2FRAS1 related extracellular matrix 2. (3168 aa)
HSPG2Heparan sulfate proteoglycan 2. (3948 aa)
DAG1Peptidase S72 domain-containing protein. (896 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1180 aa)
GP5Glycoprotein V platelet. (642 aa)
DMP1Uncharacterized protein. (429 aa)
COL2A1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1420 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
COL4A3Collagen IV NC1 domain-containing protein. (440 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (822 aa)
ITGA9Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1031 aa)
ITGA6Integrin alpha-6 heavy chain; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. (1072 aa)
CD44Link domain-containing protein. (696 aa)
SV2BSynaptic vesicle glycoprotein 2B. (705 aa)
COL9A3Collagen alpha-3(IX) chain; Collagen type IX is a minor cartilage non-fibrillar collagen. It is associated with type II collagen fibrils; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (675 aa)
COL6A1Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. (1019 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (787 aa)
AGRNAgrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clu [...] (2076 aa)
TNRTenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Involved in cell attachment and neurite formation. Interaction with CNTN1 enhances the neurite outgrowth. (1353 aa)
COL4A2Collagen IV NC1 domain-containing protein. (1847 aa)
ITGA8Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. (1076 aa)
LAMA2Uncharacterized protein. (598 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (866 aa)
LAMB4Uncharacterized protein. (1831 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (471 aa)
LOC101750889LRRCT domain-containing protein. (714 aa)
ENSGALP00000069232Uncharacterized protein. (626 aa)
TNNTenascin N. (1125 aa)
COL6A6Uncharacterized protein. (774 aa)
SDC4Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. (197 aa)
COL6A3Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein. (3215 aa)
LAMC3Uncharacterized protein. (332 aa)
COL4A6Collagen IV NC1 domain-containing protein. (170 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (202 aa)
THBS2Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions; Belongs to the thrombospondin family. (1213 aa)
SV2ASynaptic vesicle glycoprotein 2A. (751 aa)
LAMA5Laminin subunit alpha 5. (3725 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.