| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SET29602.1 | gcvT | SAMN05216326_11932 | SAMN05216326_104131 | Putative two-component system protein, hydrogenase maturation factor HypX/HoxX. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.675 |
| SET29602.1 | glyA | SAMN05216326_11932 | SAMN05216326_12141 | Putative two-component system protein, hydrogenase maturation factor HypX/HoxX. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.660 |
| SET29602.1 | purH | SAMN05216326_11932 | SAMN05216326_1514 | Putative two-component system protein, hydrogenase maturation factor HypX/HoxX. | IMP cyclohydrolase. | 0.656 |
| SET29602.1 | purN | SAMN05216326_11932 | SAMN05216326_12415 | Putative two-component system protein, hydrogenase maturation factor HypX/HoxX. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.602 |
| fmt | gcvT | SAMN05216326_12624 | SAMN05216326_104131 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.915 |
| fmt | glyA | SAMN05216326_12624 | SAMN05216326_12141 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
| fmt | purH | SAMN05216326_12624 | SAMN05216326_1514 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | IMP cyclohydrolase. | 0.548 |
| fmt | purN | SAMN05216326_12624 | SAMN05216326_12415 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.917 |
| gcvT | SET29602.1 | SAMN05216326_104131 | SAMN05216326_11932 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Putative two-component system protein, hydrogenase maturation factor HypX/HoxX. | 0.675 |
| gcvT | fmt | SAMN05216326_104131 | SAMN05216326_12624 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.915 |
| gcvT | glyA | SAMN05216326_104131 | SAMN05216326_12141 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
| gcvT | purH | SAMN05216326_104131 | SAMN05216326_1514 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | IMP cyclohydrolase. | 0.939 |
| gcvT | purN | SAMN05216326_104131 | SAMN05216326_12415 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.929 |
| gcvT | purT | SAMN05216326_104131 | SAMN05216326_11914 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.906 |
| glyA | SET29602.1 | SAMN05216326_12141 | SAMN05216326_11932 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative two-component system protein, hydrogenase maturation factor HypX/HoxX. | 0.660 |
| glyA | fmt | SAMN05216326_12141 | SAMN05216326_12624 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.924 |
| glyA | gcvT | SAMN05216326_12141 | SAMN05216326_104131 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.998 |
| glyA | purH | SAMN05216326_12141 | SAMN05216326_1514 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | IMP cyclohydrolase. | 0.994 |
| glyA | purN | SAMN05216326_12141 | SAMN05216326_12415 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.985 |
| glyA | purT | SAMN05216326_12141 | SAMN05216326_11914 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.906 |