(9 nodes) Tricarboxylic acid cycle enzyme complex network (Psilocybe cyanescens)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	CVT25_003286	Lipoyl-binding domain-containing protein. (439 aa)
	CVT25_011317	Transket_pyr domain-containing protein. (418 aa)
	CVT25_003112	Transket_pyr domain-containing protein. (1010 aa)
	CVT25_002024	Isochorismatase domain-containing protein. (220 aa)
	CVT25_002206	Uncharacterized protein. (501 aa)
	CVT25_014915	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (416 aa)
	CVT25_014015	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (585 aa)
	CVT25_015358	Dihydrolipoyl dehydrogenase. (504 aa)
	CVT25_004317	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (441 aa)

Your Current Organism:

Psilocybe cyanescens

NCBI taxonomy Id: 93625
Other names: P. cyanescens, PRM 901481

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT25_002024	CVT25_002206	A0A409X046	A0A409XF21	Isochorismatase domain-containing protein.	Uncharacterized protein.	0.583
CVT25_002024	CVT25_003112	A0A409X046	A0A409XQT2	Isochorismatase domain-containing protein.	Transket_pyr domain-containing protein.	0.995
CVT25_002024	CVT25_004317	A0A409X046	A0A409XPW4	Isochorismatase domain-containing protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.972
CVT25_002024	CVT25_011317	A0A409X046	A0A409WGE7	Isochorismatase domain-containing protein.	Transket_pyr domain-containing protein.	0.959
CVT25_002024	CVT25_014015	A0A409X046	A0A409XPN1	Isochorismatase domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.937
CVT25_002024	CVT25_014915	A0A409X046	A0A409XI16	Isochorismatase domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.918
CVT25_002024	CVT25_015358	A0A409X046	A0A409XPT6	Isochorismatase domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.994
CVT25_002206	CVT25_002024	A0A409XF21	A0A409X046	Uncharacterized protein.	Isochorismatase domain-containing protein.	0.583
CVT25_002206	CVT25_003112	A0A409XF21	A0A409XQT2	Uncharacterized protein.	Transket_pyr domain-containing protein.	0.872
CVT25_002206	CVT25_003286	A0A409XF21	A0A409WMH9	Uncharacterized protein.	Lipoyl-binding domain-containing protein.	0.722
CVT25_002206	CVT25_004317	A0A409XF21	A0A409XPW4	Uncharacterized protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.499
CVT25_002206	CVT25_011317	A0A409XF21	A0A409WGE7	Uncharacterized protein.	Transket_pyr domain-containing protein.	0.470
CVT25_002206	CVT25_014015	A0A409XF21	A0A409XPN1	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.959
CVT25_002206	CVT25_014915	A0A409XF21	A0A409XI16	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.910
CVT25_002206	CVT25_015358	A0A409XF21	A0A409XPT6	Uncharacterized protein.	Dihydrolipoyl dehydrogenase.	0.937
CVT25_003112	CVT25_002024	A0A409XQT2	A0A409X046	Transket_pyr domain-containing protein.	Isochorismatase domain-containing protein.	0.995
CVT25_003112	CVT25_002206	A0A409XQT2	A0A409XF21	Transket_pyr domain-containing protein.	Uncharacterized protein.	0.872
CVT25_003112	CVT25_003286	A0A409XQT2	A0A409WMH9	Transket_pyr domain-containing protein.	Lipoyl-binding domain-containing protein.	0.999
CVT25_003112	CVT25_004317	A0A409XQT2	A0A409XPW4	Transket_pyr domain-containing protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.791
CVT25_003112	CVT25_011317	A0A409XQT2	A0A409WGE7	Transket_pyr domain-containing protein.	Transket_pyr domain-containing protein.	0.848