STRINGSTRING
EHQ36003.1 EHQ36003.1 EHQ36517.1 EHQ36517.1 EHQ36651.1 EHQ36651.1 EHQ36720.1 EHQ36720.1 rfcL rfcL lig lig EHQ34176.1 EHQ34176.1 pcn pcn priL priL dnaG dnaG rfcS rfcS EHQ34572.1 EHQ34572.1 EHQ34581.1 EHQ34581.1 fen fen EHQ34867.1 EHQ34867.1 polC polC EHQ35083.1 EHQ35083.1 EHQ35287.1 EHQ35287.1 EHQ35289.1 EHQ35289.1 polB polB EHQ35536.1 EHQ35536.1 EHQ35615.1 EHQ35615.1 EHQ35676.1 EHQ35676.1 priS priS rnhB rnhB EHQ35934.1 EHQ35934.1 EHQ36203.1 EHQ36203.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EHQ36003.1DEAD-like helicase; PFAM: Type III restriction enzyme, res subunit; COGs: COG1112 Superfamily I DNA and RNA helicase and helicase subunits; InterPro IPR014001; KEGG: vcj:VCD_003701 hypothetical protein; SMART: DEAD-like helicase, N-terminal; SPTR: Putative uncharacterized protein. (887 aa)
EHQ36517.1Transcriptional regulator, XRE family; PFAM: Helix-turn-helix; COGs: COG1476 transcriptional regulator protein; InterPro IPR001387; KEGG: mpi:Mpet_2820 XRE family transcriptional regulator; PFAM: Helix-turn-helix type 3; SMART: Helix-turn-helix type 3; SPTR: Transcriptional regulator, XRE family. (64 aa)
EHQ36651.1Transcriptional regulator, XRE family; PFAM: CBS domain; Helix-turn-helix; COGs: COG3620 transcriptional regulator protein; InterPro IPR001387:IPR000644; KEGG: mpi:Mpet_2089 XRE family transcriptional regulator; PFAM: Cystathionine beta-synthase, core; Helix-turn-helix type 3; SMART: Helix-turn-helix type 3; Cystathionine beta-synthase, core; SPTR: Transcriptional regulator, XRE family. (184 aa)
EHQ36720.1KEGG: hypothetical protein; SPTR: Putative uncharacterized protein. (252 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (497 aa)
ligDNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (549 aa)
EHQ34176.1PFAM: RNase3 domain; COGs: COG0571 dsRNA-specific ribonuclease; InterPro IPR000999; KEGG: mpi:Mpet_1497 ribonuclease III; PFAM: Ribonuclease III; SMART: Ribonuclease III; SPTR: Ribonuclease III. (156 aa)
pcnMonomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (247 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (381 aa)
dnaGUPF0095 protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (403 aa)
rfcSReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (325 aa)
EHQ34572.1Replicative DNA helicase Mcm; PFAM: MCM2/3/5 family; COGs: COG1241 ATPase involved in replication control Cdc46/Mcm family; InterPro IPR001208; KEGG: mpi:Mpet_0979 MCM family protein; PFAM: DNA-dependent ATPase MCM; SMART: DNA-dependent ATPase MCM; SPTR: MCM family protein; Belongs to the MCM family. (706 aa)
EHQ34581.1Replication factor C; PFAM: ATPase family associated with various cellular activities (AAA); Replication factor C; COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR003959:IPR013748; KEGG: mpi:Mpet_0988 replication factor C; PFAM: Replication factor C; ATPase, AAA-type, core; SPTR: Replication factor C. (332 aa)
fenFlap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (333 aa)
EHQ34867.1Hypothetical protein; KEGG: mpi:Mpet_0705 nucleic acid binding OB-fold tRNA/helicase-type protein; SPTR: Nucleic acid binding, OB-fold, tRNA/helicase-type. (560 aa)
polCDNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1299 aa)
EHQ35083.1Transcriptional regulator, XRE family; PFAM: Helix-turn-helix; COGs: COG1476 transcriptional regulator protein; InterPro IPR001387; KEGG: mba:Mbar_A0692 XRE family transcriptional regulator; PFAM: Helix-turn-helix type 3; SMART: Helix-turn-helix type 3; SPTR: Transcriptional regulator, XRE family. (63 aa)
EHQ35287.1PFAM: OB-fold nucleic acid binding domain; COGs: COG1599 Single-stranded DNA-binding replication protein A (RPA) large (70 kD) subunit and related ssDNA-binding protein; InterPro IPR004365; KEGG: mpi:Mpet_0146 nucleic acid binding OB-fold tRNA/helicase-type protein; PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; SPTR: Nucleic acid binding OB-fold tRNA/helicase-type. (417 aa)
EHQ35289.1PFAM: OB-fold nucleic acid binding domain; COGs: COG1599 Single-stranded DNA-binding replication protein A (RPA) large (70 kD) subunit and related ssDNA-binding protein; InterPro IPR004365; KEGG: mpi:Mpet_0146 nucleic acid binding OB-fold tRNA/helicase-type protein; PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; SPTR: Nucleic acid binding OB-fold tRNA/helicase-type. (424 aa)
polBDNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (497 aa)
EHQ35536.1PFAM: Exonuclease; COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; InterPro IPR006055:IPR013520; KEGG: osp:Odosp_0764 exonuclease RNase T and DNA polymerase III; PFAM: Exonuclease, RNase T/DNA polymerase III; SMART: Exonuclease; SPTR: Exonuclease RNase T and DNA polymerase III. (213 aa)
EHQ35615.1Ribonuclease HIII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (353 aa)
EHQ35676.1PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006172:IPR006133:IPR006134; KEGG: mpi:Mpet_1929 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. (843 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (380 aa)
rnhBRNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (212 aa)
EHQ35934.1Cobyrinic acid ac-diamide synthase; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain; COGs: COG1192 ATPase involved in chromosome partitioning; InterPro IPR002586; KEGG: mpi:Mpet_1655 cobyrinic acid ac-diamide synthase; PFAM: Cobyrinic acid a,c-diamide synthase; SPTR: Cobyrinic acid ac-diamide synthase; manually curated. (280 aa)
EHQ36203.1Helix-turn-helix domain protein; PFAM: Helix-turn-helix; InterPro IPR001387; KEGG: mbn:Mboo_0371 XRE family transcriptional regulator; PFAM: Helix-turn-helix type 3; SMART: Helix-turn-helix type 3; SPTR: Putative transcriptional regulator, XRE family. (89 aa)
Your Current Organism:
Methanoplanus limicola
NCBI taxonomy Id: 937775
Other names: M. limicola DSM 2279, Methanoplanus limicola DSM 2279, Methanoplanus limicola str. DSM 2279, Methanoplanus limicola strain DSM 2279
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