(32 nodes) Ubiquitin-dependent ERAD pathway network (Salpingoeca rosetta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTSG_10855	J domain-containing protein. (399 aa)
	PTSG_10842	Ubiquitin thioesterase OTU1. (306 aa)
	PTSG_12987	Uncharacterized protein. (2096 aa)
	PTSG_09402	bVLRF1 domain-containing protein. (476 aa)
	PTSG_09044	UBX domain-containing protein. (433 aa)
	PTSG_12582	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (870 aa)
	PTSG_00613	Uncharacterized protein. (940 aa)
	PTSG_11632	Uncharacterized protein. (230 aa)
	PTSG_01891	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (461 aa)
	PTSG_01086	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (244 aa)
	PTSG_01187	Uncharacterized protein. (926 aa)
	PTSG_02184	RING-type domain-containing protein. (539 aa)
	PTSG_02246	AZUL domain-containing protein. (720 aa)
	PTSG_02504	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (730 aa)
	PTSG_04132	UBIQUITIN_CONJUGAT_2 domain-containing protein. (338 aa)
	PTSG_04191	UBX domain-containing protein. (741 aa)
	PTSG_03953	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family. (391 aa)
	PTSG_04621	UBX domain-containing protein. (309 aa)
	PTSG_04660	SmIrV1 protein. (545 aa)
	PTSG_04395	Heat shock protein gp96. (850 aa)
	PTSG_05009	U-box domain-containing protein. (1134 aa)
	PTSG_05166	RING-type domain-containing protein. (561 aa)
	PTSG_05593	Molecular chaperone DnaJ. (683 aa)
	PTSG_06150	Uncharacterized protein. (317 aa)
	PTSG_06253	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (854 aa)
	PTSG_07223	Preimmunoglobulin heavy chain binding protein; Belongs to the heat shock protein 70 family. (652 aa)
	PTSG_06462	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (304 aa)
	PTSG_12671	UBX domain-containing protein. (485 aa)
	PTSG_09535	Uncharacterized protein. (314 aa)
	PTSG_12809	Uncharacterized protein. (491 aa)
	PTSG_08803	Foxred2 protein. (1193 aa)
	PTSG_08658	TPR_REGION domain-containing protein. (1321 aa)

Your Current Organism:

Salpingoeca rosetta

NCBI taxonomy Id: 946362
Other names: Proterospongia sp. ATCC 50818, S. rosetta, Salpingoeca rosetta ATCC 50818, Salpingoeca rosetta ATCC50818, Salpingoeca rosetta Dayel et al. 2011, Salpingoeca sp. ATCC 50818, Salpingoeca sp. ATCC50818

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PTSG_01086	PTSG_01187	F2U0S0	F2U124	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.625
PTSG_01086	PTSG_02184	F2U0S0	F2U1G4	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	RING-type domain-containing protein.	0.997
PTSG_01086	PTSG_02246	F2U0S0	F2U1M5	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	AZUL domain-containing protein.	0.777
PTSG_01086	PTSG_04132	F2U0S0	F2U6P1	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.534
PTSG_01086	PTSG_04191	F2U0S0	F2U6V2	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	UBX domain-containing protein.	0.539
PTSG_01086	PTSG_04395	F2U0S0	F2U8F6	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Heat shock protein gp96.	0.445
PTSG_01086	PTSG_04621	F2U0S0	F2U7Y7	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	UBX domain-containing protein.	0.539
PTSG_01086	PTSG_04660	F2U0S0	F2U824	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	SmIrV1 protein.	0.516
PTSG_01086	PTSG_06462	F2U0S0	F2UFV7	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.994
PTSG_01086	PTSG_07223	F2U0S0	F2UEF0	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Preimmunoglobulin heavy chain binding protein; Belongs to the heat shock protein 70 family.	0.973
PTSG_01086	PTSG_12671	F2U0S0	F2UHS3	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	UBX domain-containing protein.	0.565
PTSG_01086	PTSG_12809	F2U0S0	F2UL24	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.991
PTSG_01187	PTSG_01086	F2U124	F2U0S0	Uncharacterized protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.625
PTSG_01187	PTSG_02184	F2U124	F2U1G4	Uncharacterized protein.	RING-type domain-containing protein.	0.768
PTSG_01187	PTSG_02246	F2U124	F2U1M5	Uncharacterized protein.	AZUL domain-containing protein.	0.505
PTSG_01187	PTSG_04191	F2U124	F2U6V2	Uncharacterized protein.	UBX domain-containing protein.	0.534
PTSG_01187	PTSG_04621	F2U124	F2U7Y7	Uncharacterized protein.	UBX domain-containing protein.	0.510
PTSG_01187	PTSG_05009	F2U124	F2U990	Uncharacterized protein.	U-box domain-containing protein.	0.467
PTSG_01187	PTSG_05166	F2U124	F2UAP7	Uncharacterized protein.	RING-type domain-containing protein.	0.459
PTSG_01187	PTSG_06462	F2U124	F2UFV7	Uncharacterized protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.545

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