STRINGSTRING
PLCG2 PLCG2 RPS6KB1 RPS6KB1 PPP1R14B PPP1R14B MAP2K2 MAP2K2 EIF4E2 EIF4E2 LOC108282470 LOC108282470 ENSCCAP00000003376 ENSCCAP00000003376 LOC108294221 LOC108294221 LOC108304333 LOC108304333 BAD BAD EIF4E1B EIF4E1B LOC108300898 LOC108300898 EGF EGF CSDE1 CSDE1 LOC108313878 LOC108313878 MAPK3 MAPK3 IGF1 IGF1 PIK3R2 PIK3R2 PRKCB PRKCB EIF4EBP1 EIF4EBP1 IL6R IL6R ARAF ARAF CEP152 CEP152 NRG1 NRG1 HGF HGF AKT1 AKT1 TBCA TBCA SHC1 SHC1 ERBB3 ERBB3 PDGFC PDGFC PDGFD PDGFD ENSCCAP00000031241 ENSCCAP00000031241 ERBB2 ERBB2 VEGFA VEGFA TGFA TGFA LOC108284022 LOC108284022 KRAS KRAS GRB2 GRB2 PDGFRB PDGFRB HRAS HRAS MET MET BRAF BRAF RPS6 RPS6 SHC2 SHC2 GAS6 GAS6 FOXO3 FOXO3 ENSCCAP00000026158 ENSCCAP00000026158 NRAS NRAS PDGFB PDGFB ENSCCAP00000025671 ENSCCAP00000025671 IGF1R IGF1R FGFR3 FGFR3 ENSCCAP00000023514 ENSCCAP00000023514 EIF4E EIF4E FGFR2 FGFR2 PIK3CB PIK3CB RPS6KB2 RPS6KB2 MTOR MTOR PIK3CA PIK3CA GAB1 GAB1 AKT2 AKT2 NF1 NF1 ENSCCAP00000019119 ENSCCAP00000019119 KDR KDR PDGFA PDGFA SHC4 SHC4 STAT3 STAT3 SOS1 SOS1 AXL AXL MAPK1 MAPK1 GSK3B GSK3B SHC3 SHC3 ENSCCAP00000013066 ENSCCAP00000013066 LOC108282680 LOC108282680 PIK3R3 PIK3R3 PRKCG PRKCG EGFR EGFR SOS2 SOS2 PDGFRA PDGFRA BAX BAX IL6 IL6 ENSCCAP00000011758 ENSCCAP00000011758 PRKCA PRKCA BCL2L1 BCL2L1 PLCG1 PLCG1 FGF2 FGF2 RAF1 RAF1 AKT3 AKT3 ENSCCAP00000010305 ENSCCAP00000010305 JAK2 JAK2 BCL2L11 BCL2L11 NRG2 NRG2 SRC SRC JAK1 JAK1 PIK3CD PIK3CD PTEN PTEN PIK3R1 PIK3R1 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
MAP2K2Mitogen-activated protein kinase kinase 2. (303 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
LOC10828247040S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ENSCCAP00000003376Protein kinase domain-containing protein. (184 aa)
LOC10829422140S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (216 aa)
LOC10830433340S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
BADBCL2 associated agonist of cell death. (167 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (238 aa)
LOC108300898Protein kinase domain-containing protein. (271 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
CSDE1Uncharacterized protein. (844 aa)
LOC108313878Uncharacterized protein. (523 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IGF1Insulin like growth factor 1. (199 aa)
PIK3R2Uncharacterized protein. (727 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
IL6RInterleukin 6 receptor. (468 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
CEP152Centrosomal protein 152. (1658 aa)
NRG1Neuregulin 1. (713 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (132 aa)
SHC1SHC adaptor protein 1. (577 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1352 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
ENSCCAP00000031241Uncharacterized protein. (387 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (456 aa)
TGFATransforming growth factor alpha. (165 aa)
LOC108284022Uncharacterized protein. (199 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
SHC2Uncharacterized protein. (536 aa)
GAS6Growth arrest specific 6. (676 aa)
FOXO3Forkhead box O3. (672 aa)
ENSCCAP00000026158CSD_1 domain-containing protein. (440 aa)
NRASUncharacterized protein. (189 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSCCAP00000025671Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (118 aa)
IGF1RTyrosine-protein kinase receptor. (1285 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
ENSCCAP00000023514Uncharacterized protein. (89 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (248 aa)
FGFR2Fibroblast growth factor receptor. (782 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
MTORSerine/threonine-protein kinase mTOR. (2508 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NF1Neurofibromin 1. (2839 aa)
ENSCCAP00000019119Uncharacterized protein. (129 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
SHC4SHC adaptor protein 4. (628 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1329 aa)
AXLAXL receptor tyrosine kinase. (896 aa)
MAPK1Mitogen-activated protein kinase. (366 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (434 aa)
SHC3SHC adaptor protein 3. (598 aa)
ENSCCAP00000013066Uncharacterized protein. (96 aa)
LOC108282680Protein kinase domain-containing protein. (245 aa)
PIK3R3Uncharacterized protein. (577 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
BAXBCL2 associated X, apoptosis regulator. (159 aa)
IL6Interleukin 6. (212 aa)
ENSCCAP00000011758PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (191 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
BCL2L1BCL2 like 1. (233 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
AKT3AKT serine/threonine kinase 3. (472 aa)
ENSCCAP00000010305Uncharacterized protein. (181 aa)
JAK2Tyrosine-protein kinase. (1136 aa)
BCL2L11BCL2 like 11. (200 aa)
NRG2Neuregulin 2. (846 aa)
SRCTyrosine-protein kinase. (542 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1056 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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