STRINGSTRING
SPARC SPARC SPRY2 SPRY2 SEMA4A SEMA4A TNF TNF SYNJ2BP SYNJ2BP COL4A2 COL4A2 TNMD TNMD PML PML TGFB2 TGFB2 ATF2 ATF2 PTPRM PTPRM PIK3CB PIK3CB COL4A3 COL4A3 CTNNB1 CTNNB1 ADAMTS9 ADAMTS9 THBS2 THBS2 SLC12A2 SLC12A2 PLK2 PLK2 HGS HGS GPR4 GPR4 YJEFN3 YJEFN3 ATP2B4 ATP2B4 ALOX5 ALOX5 CLDN5 CLDN5 EMILIN1 EMILIN1 SPINK5 SPINK5 HSPG2 HSPG2 ADGRB2 ADGRB2 CREB3L1 CREB3L1 ENSMFAP00000016088 ENSMFAP00000016088 GTF2I GTF2I SPRED1 SPRED1 GDF2 GDF2 E2F2 E2F2 NPPB NPPB ADGRB1 ADGRB1 VASH1 VASH1 AMOT AMOT PF4 PF4 HRG HRG APOH APOH SEMA3E SEMA3E NPR1 NPR1 THBS1 THBS1 FOXC1 FOXC1 MECP2 MECP2 KRIT1 KRIT1 THBS4 THBS4 FOXJ2 FOXJ2 KLF4 KLF4 ABCC8 ABCC8 GADD45A GADD45A RGCC RGCC FOXO4 FOXO4 CNMD CNMD SARS1 SARS1 ROCK2 ROCK2 SULF1 SULF1 GHRL GHRL NAXE NAXE PDE3B PDE3B CD160 CD160 ENSMFAP00000025660 ENSMFAP00000025660 SERPINF1 SERPINF1 ANGPT2 ANGPT2 IL17F IL17F TEK TEK EPHA2 EPHA2 STAB1 STAB1 ECSCR ECSCR HOXA5 HOXA5 ANGPT4 ANGPT4 DAB2IP DAB2IP TBC1D31 TBC1D31 STAT1 STAT1 TIE1 TIE1 AGO1 AGO1 HHEX HHEX ROCK1 ROCK1 ISM1 ISM1 ADGRB3 ADGRB3 NIBAN2 NIBAN2 DCN DCN CXCL10 CXCL10 EPN2 EPN2 NF1 NF1 EPN1 EPN1 SEMA6A SEMA6A ADAMTS1 ADAMTS1 FASLG FASLG SERPINE1 SERPINE1 MINAR1 MINAR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPARCSecreted protein acidic and cysteine rich. (303 aa)
SPRY2Protein sprouty homolog 2; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. (338 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (760 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
COL4A2Collagen type IV alpha 2 chain. (1724 aa)
TNMDTenomodulin. (317 aa)
PMLPromyelocytic leukemia. (882 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1465 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
CTNNB1Catenin beta 1. (781 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
THBS2Thrombospondin 2. (1172 aa)
SLC12A2Solute carrier family 12 member 2. (1210 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (830 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
YJEFN3YjeF N-terminal domain containing 3. (291 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
SPINK5Serine peptidase inhibitor, Kazal type 5. (1087 aa)
HSPG2Heparan sulfate proteoglycan 2. (4391 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1587 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
ENSMFAP00000016088Uncharacterized protein. (123 aa)
GTF2IGeneral transcription factor IIi. (998 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
GDF2Growth differentiation factor 2. (429 aa)
E2F2E2F transcription factor 2. (437 aa)
NPPBNatriuretic peptide B. (132 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1566 aa)
VASH1Vasohibin 1. (365 aa)
AMOTAngiomotin. (1099 aa)
PF4C-X-C motif chemokine. (101 aa)
HRGHistidine rich glycoprotein. (525 aa)
APOHUncharacterized protein. (355 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (745 aa)
NPR1Guanylate cyclase. (1061 aa)
THBS1Thrombospondin 1. (1173 aa)
FOXC1Forkhead box C1. (504 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
KRIT1Uncharacterized protein. (736 aa)
THBS4Thrombospondin 4. (961 aa)
FOXJ2Forkhead box J2. (574 aa)
KLF4Testis cDNA clone: QtsA-19426, similar to human Kruppel-like factor 4 (gut) (KLF4). (479 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
RGCCRegulator of cell cycle. (137 aa)
FOXO4Forkhead box O4. (505 aa)
CNMDChondromodulin. (333 aa)
SARS1Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16 [...] (491 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
PDE3BPhosphodiesterase. (1117 aa)
CD160CD160 molecule. (233 aa)
ENSMFAP00000025660Uncharacterized protein. (342 aa)
SERPINF1SERPIN domain-containing protein; Belongs to the serpin family. (406 aa)
ANGPT2Angiopoietin 2. (496 aa)
IL17FInterleukin 17F. (163 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
EPHA2Ephrin type-A receptor 2; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin- A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DS [...] (1036 aa)
STAB1Stabilin 1. (2568 aa)
ECSCRUncharacterized protein. (205 aa)
HOXA5Homeobox A5. (270 aa)
ANGPT4Angiopoietin 4. (503 aa)
DAB2IPDAB2 interacting protein. (1153 aa)
TBC1D31Uncharacterized protein. (1067 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
HHEXHematopoietically expressed homeobox. (270 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
ISM1Isthmin 1. (418 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
NIBAN2Niban apoptosis regulator 2. (746 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
CXCL10C-X-C motif chemokine. (98 aa)
EPN2Epsin 2. (641 aa)
NF1Neurofibromin 1. (2849 aa)
EPN1Epsin 1. (662 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (916 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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