(67 nodes) SCF ubiquitin ligase complex network (Macaca fascicularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	FBXL4	F-box and leucine rich repeat protein 4. (621 aa)
	SPSB2	SplA/ryanodine receptor domain and SOCS box containing 2. (257 aa)
	FBXL15	F-box and leucine rich repeat protein 15. (300 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	FBXL17	F-box and leucine rich repeat protein 17. (702 aa)
	ENSMFAP00000007435	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (108 aa)
	FBXW8	F-box and WD repeat domain containing 8. (598 aa)
	FBXW5	F-box and WD repeat domain containing 5. (566 aa)
	FBXL8	F-box domain-containing protein. (386 aa)
	LOC102132252	FBA domain-containing protein. (110 aa)
	NCCRP1	Non-specific cytotoxic cell receptor protein 1 homolog (zebrafish). (275 aa)
	BTRC	Uncharacterized protein. (605 aa)
	FBXO2	F-box protein 2. (297 aa)
	SKP2	S-phase kinase associated protein 2. (424 aa)
	FBXO15	F-box only protein 15; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (510 aa)
	SPSB3	SplA/ryanodine receptor domain and SOCS box containing 3. (355 aa)
	FBXL2	F-box and leucine rich repeat protein 2. (220 aa)
	ENSMFAP00000020763	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (65 aa)
	FBXL20	F-box and leucine rich repeat protein 20. (406 aa)
	ENSMFAP00000021359	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (93 aa)
	FBXO18	Uncharacterized protein. (344 aa)
	FBXO39	F-box protein 39. (442 aa)
	FBXO45	F-box protein 45. (320 aa)
	FBXL6	F-box and leucine rich repeat protein 6. (529 aa)
	FBXL5	F-box and leucine rich repeat protein 5. (691 aa)
	FBXO6	F-box protein 6. (293 aa)
	FBXO4	F-box protein 4. (387 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	FBXO33	F-box protein 33. (555 aa)
	USP47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
	FBXO9	F-box protein 9. (457 aa)
	ENSMFAP00000025792	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (78 aa)
	FBXL3	F-box and leucine rich repeat protein 3. (428 aa)
	FBXW4	F-box and WD repeat domain containing 4. (410 aa)
	FBXO25	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). (367 aa)
	FBXL18	F-box and leucine rich repeat protein 18. (718 aa)
	LRRC29	Leucine rich repeat containing 29. (221 aa)
	SPSB4	SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa)
	ENSMFAP00000030335	Uncharacterized protein; Belongs to the SKP1 family. (141 aa)
	FBXL12	F-box and leucine rich repeat protein 12. (326 aa)
	SPSB1	SplA/ryanodine receptor domain and SOCS box containing 1. (273 aa)
	ENSMFAP00000031351	Uncharacterized protein; Belongs to the SKP1 family. (166 aa)
	FBXO7	F-box protein 7. (522 aa)
	FBXL19	F-box and leucine rich repeat protein 19. (694 aa)
	FBXL14	F-box and leucine rich repeat protein 14. (418 aa)
	AMN1	Antagonist of mitotic exit network 1 homolog. (258 aa)
	FBXL16	F-box and leucine rich repeat protein 16. (479 aa)
	FBXL21P	F-box domain-containing protein. (434 aa)
	FBXO42	F-box protein 42. (716 aa)
	FBXO31	F-box protein 31. (639 aa)
	FBXO48	F-box protein 48. (155 aa)
	FBXO27	F-box only protein 27; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides. (280 aa)
	FBXW7	F-box and WD repeat domain containing 7. (707 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	GSE1	Gse1 coiled-coil protein. (1326 aa)
	FBXW11	F-box and WD repeat domain containing 11. (542 aa)
	RBX1	RING-box protein 1. (108 aa)
	FBXO32	F-box protein 32. (355 aa)
	FBXO44	Uncharacterized protein. (255 aa)
	SKP1	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (167 aa)
	CCNF	Cyclin F; Belongs to the cyclin family. (786 aa)
	FBXO38	F-box protein 38. (1188 aa)
	FBXL7	F-box and leucine rich repeat protein 7. (491 aa)
	FBXL13	F-box and leucine rich repeat protein 13. (735 aa)
	FBXL22	F-box and leucine rich repeat protein 22. (236 aa)
	ENSMFAP00000045746	Zf-rbx1 domain-containing protein. (93 aa)
	CACYBP	Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). (228 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMN1	CUL1	ENSMFAP00000033450	ENSMFAP00000039912	Antagonist of mitotic exit network 1 homolog.	Cullin 1; Belongs to the cullin family.	0.503
AMN1	ENSMFAP00000030335	ENSMFAP00000033450	ENSMFAP00000030335	Antagonist of mitotic exit network 1 homolog.	Uncharacterized protein; Belongs to the SKP1 family.	0.549
AMN1	ENSMFAP00000031351	ENSMFAP00000033450	ENSMFAP00000031351	Antagonist of mitotic exit network 1 homolog.	Uncharacterized protein; Belongs to the SKP1 family.	0.549
AMN1	ENSMFAP00000045746	ENSMFAP00000033450	ENSMFAP00000045746	Antagonist of mitotic exit network 1 homolog.	Zf-rbx1 domain-containing protein.	0.464
AMN1	RBX1	ENSMFAP00000033450	ENSMFAP00000042809	Antagonist of mitotic exit network 1 homolog.	RING-box protein 1.	0.464
AMN1	SKP1	ENSMFAP00000033450	ENSMFAP00000043769	Antagonist of mitotic exit network 1 homolog.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...]	0.549
BTRC	CCNF	ENSMFAP00000010380	ENSMFAP00000044202	Uncharacterized protein.	Cyclin F; Belongs to the cyclin family.	0.553
BTRC	CUL1	ENSMFAP00000010380	ENSMFAP00000039912	Uncharacterized protein.	Cullin 1; Belongs to the cullin family.	0.999
BTRC	ENSMFAP00000030335	ENSMFAP00000010380	ENSMFAP00000030335	Uncharacterized protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.917
BTRC	ENSMFAP00000031351	ENSMFAP00000010380	ENSMFAP00000031351	Uncharacterized protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.917
BTRC	ENSMFAP00000045746	ENSMFAP00000010380	ENSMFAP00000045746	Uncharacterized protein.	Zf-rbx1 domain-containing protein.	0.932
BTRC	FBXO2	ENSMFAP00000010380	ENSMFAP00000013975	Uncharacterized protein.	F-box protein 2.	0.939
BTRC	FBXO4	ENSMFAP00000010380	ENSMFAP00000023852	Uncharacterized protein.	F-box protein 4.	0.915
BTRC	FBXO6	ENSMFAP00000010380	ENSMFAP00000023575	Uncharacterized protein.	F-box protein 6.	0.463
BTRC	FBXW11	ENSMFAP00000010380	ENSMFAP00000042731	Uncharacterized protein.	F-box and WD repeat domain containing 11.	0.975
BTRC	FBXW7	ENSMFAP00000010380	ENSMFAP00000039581	Uncharacterized protein.	F-box and WD repeat domain containing 7.	0.948
BTRC	FBXW8	ENSMFAP00000010380	ENSMFAP00000007833	Uncharacterized protein.	F-box and WD repeat domain containing 8.	0.442
BTRC	RBX1	ENSMFAP00000010380	ENSMFAP00000042809	Uncharacterized protein.	RING-box protein 1.	0.992
BTRC	SKP1	ENSMFAP00000010380	ENSMFAP00000043769	Uncharacterized protein.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...]	0.991
BTRC	SKP2	ENSMFAP00000010380	ENSMFAP00000014684	Uncharacterized protein.	S-phase kinase associated protein 2.	0.961

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