STRINGSTRING
SGPL1 SGPL1 GAS2 GAS2 ESR1 ESR1 MAP2K6 MAP2K6 FSHB FSHB ADAMTS1 ADAMTS1 PLEKHA1 PLEKHA1 SIRT1 SIRT1 INHBA INHBA CGA CGA FZD4 FZD4 PTX3 PTX3 AMH AMH MMP2 MMP2 BMPR1B BMPR1B CASP2 CASP2 NR5A1 NR5A1 STAT5B STAT5B LHCGR LHCGR SRC SRC GPR149 GPR149 SCAPER SCAPER NPY5R NPY5R PTPRN PTPRN FSHR FSHR NRIP1 NRIP1 ZNF830 ZNF830 TGFB3 TGFB3 EREG EREG SLIT3 SLIT3 TNFAIP6 TNFAIP6 RESP18 RESP18 AFP AFP PAM PAM MMP19 MMP19 TGFB2 TGFB2 NOS3 NOS3 ROBO2 ROBO2 SLIT2 SLIT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SGPL1Sphingosine-1-phosphate lyase 1. (560 aa)
GAS2Growth arrest specific 2. (331 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
MAP2K6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs (By similarity). (129 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
PLEKHA1Pleckstrin homology domain containing A1. (404 aa)
SIRT1Sirtuin 1. (743 aa)
INHBAInhibin subunit beta A. (426 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (150 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (524 aa)
PTX3Pentraxin 3. (381 aa)
AMHAnti-Mullerian hormone. (562 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
STAT5BSignal transducer and activator of transcription. (763 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (703 aa)
SRCTyrosine-protein kinase. (542 aa)
GPR149G protein-coupled receptor 149. (731 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1400 aa)
NPY5RNeuropeptide Y receptor Y5. (455 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (970 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
ZNF830Zinc finger protein 830. (388 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
EREGEpiregulin. (169 aa)
SLIT3Slit guidance ligand 3. (1480 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
RESP18Regulated endocrine specific protein 18. (219 aa)
AFPAlpha fetoprotein. (622 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (976 aa)
MMP19Matrix metallopeptidase 19. (508 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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