STRINGSTRING
RB1 RB1 SLIT2 SLIT2 TGFB1 TGFB1 KCNK2 KCNK2 MYL10 MYL10 OSTN OSTN TRIM46 TRIM46 SEMA4A SEMA4A EPHA7 EPHA7 ENSMFAP00000001456 ENSMFAP00000001456 SEMA7A SEMA7A JADE1 JADE1 CITED2 CITED2 SEMA4B SEMA4B TNR TNR CDA CDA PPP2R1A PPP2R1A GDF9 GDF9 CYP27B1 CYP27B1 CDKN1A CDKN1A ENSMFAP00000004047 ENSMFAP00000004047 SMAD3 SMAD3 PNPT1 PNPT1 LOC102126088 LOC102126088 SEMA3F SEMA3F CDK5 CDK5 ENSMFAP00000005291 ENSMFAP00000005291 PML PML SEMA4D SEMA4D ENSMFAP00000005456 ENSMFAP00000005456 TGFB2 TGFB2 SEMA5B SEMA5B MT1F MT1F RAI1 RAI1 ENSMFAP00000005860 ENSMFAP00000005860 BTG1 BTG1 MAPK11 MAPK11 BST2 BST2 GNG4 GNG4 ULK2 ULK2 ST7L ST7L ENSMFAP00000007313 ENSMFAP00000007313 DAB2 DAB2 BMP4 BMP4 SPHK2 SPHK2 BCL6 BCL6 PLAC8 PLAC8 ING4 ING4 PTPRS PTPRS STK3 STK3 SLIT3 SLIT3 ENSMFAP00000009633 ENSMFAP00000009633 SERTAD3 SERTAD3 DDX3X DDX3X LOC102124074 LOC102124074 ENSMFAP00000010204 ENSMFAP00000010204 BCL2 BCL2 AGTR2 AGTR2 VGLL4 VGLL4 BCL11A BCL11A ENSMFAP00000011899 ENSMFAP00000011899 ADRB2 ADRB2 CDKN2C CDKN2C OSGIN2 OSGIN2 CAPRIN2 CAPRIN2 NOG NOG SEMA4F SEMA4F CCN3 CCN3 MSTN MSTN PPT1 PPT1 MT3 MT3 WNT3 WNT3 RNF6 RNF6 ENSMFAP00000014215 ENSMFAP00000014215 ENSMFAP00000014396 ENSMFAP00000014396 SERTAD1 SERTAD1 ENSMFAP00000014629 ENSMFAP00000014629 CCDC85B CCDC85B PSRC1 PSRC1 STK4 STK4 FGF13 FGF13 DACT3 DACT3 WT1 WT1 ADRB1 ADRB1 NDUFS3 NDUFS3 SOCS2 SOCS2 SEMA6B SEMA6B SEMA3G SEMA3G IP6K2 IP6K2 PPARA PPARA CTDP1 CTDP1 ACVR1B ACVR1B LOC102139102 LOC102139102 DIP2B DIP2B GDF2 GDF2 LOC102141421 LOC102141421 LOC102140106 LOC102140106 PTCH1 PTCH1 NPPB NPPB DSPP DSPP BMPR2 BMPR2 CDKN1B CDKN1B ENSMFAP00000018577 ENSMFAP00000018577 HIF1A HIF1A IFRD2 IFRD2 FGFR3 FGFR3 SAV1 SAV1 CDKN2D CDKN2D LOC101867369 LOC101867369 HRG HRG SEMA3E SEMA3E NRP1 NRP1 BBS2 BBS2 NPR1 NPR1 SPART SPART FBP1 FBP1 ENSMFAP00000020785 ENSMFAP00000020785 FSTL4 FSTL4 RGS2 RGS2 BBC3 BBC3 DCC DCC MT1X MT1X ING5 ING5 SFRP1 SFRP1 ENSMFAP00000021335 ENSMFAP00000021335 FRZB FRZB HNF4A HNF4A DUSP10 DUSP10 LOC102115428 LOC102115428 MT1G MT1G SIPA1 SIPA1 TCHP TCHP ENSMFAP00000022083 ENSMFAP00000022083 PTK6 PTK6 EI24 EI24 SESN2 SESN2 ENSMFAP00000022848 ENSMFAP00000022848 SPAG9 SPAG9 ENSMFAP00000022925 ENSMFAP00000022925 WNT11 WNT11 G6PD G6PD PI16 PI16 RACK1 RACK1 SEMA3B SEMA3B SMARCA4 SMARCA4 TP53TG5 TP53TG5 SEMA3A SEMA3A GNAS GNAS STK11 STK11 LOC102137984 LOC102137984 SOX17 SOX17 SERPINE2 SERPINE2 CGRRF1 CGRRF1 MAG MAG TP73 TP73 ING1 ING1 ADAM15 ADAM15 LGMN LGMN CRLF3 CRLF3 NKD1 NKD1 TBX5 TBX5 CDHR2 CDHR2 SEMA3D SEMA3D RYK RYK PRDM11 PRDM11 SEMA6C SEMA6C SLIT1 SLIT1 NDUFA13 NDUFA13 IFRD1 IFRD1 DCBLD2 DCBLD2 SEMA4C SEMA4C WNT3A WNT3A DCSTAMP DCSTAMP RERG RERG WWC2 WWC2 C10orf90 C10orf90 FXN FXN ULK1 ULK1 PHB PHB WFDC1 WFDC1 MYL2 MYL2 PPARD PPARD JARID2 JARID2 FHL1 FHL1 DCUN1D3 DCUN1D3 MT1A MT1A SMAD4 SMAD4 TLL2 TLL2 SLC6A4 SLC6A4 MAP2 MAP2 ALOX15B ALOX15B RTN4R RTN4R HYAL1 HYAL1 RTN4 RTN4 MT1M MT1M PTEN PTEN GDF15 GDF15 ENSMFAP00000034846 ENSMFAP00000034846 TGFBR2 TGFBR2 PPP2CA PPP2CA PTPRJ PTPRJ ZC3H12D ZC3H12D WWC3 WWC3 WNT5A WNT5A ENSMFAP00000035602 ENSMFAP00000035602 TSPYL2 TSPYL2 MUL1 MUL1 RBBP7 RBBP7 MT2A MT2A FLCN FLCN SERTAD2 SERTAD2 NDRG3 NDRG3 NTN1 NTN1 SMARCA2 SMARCA2 ENSMFAP00000037410 ENSMFAP00000037410 INHBA INHBA SPP1 SPP1 SEMA4G SEMA4G SH3BP4 SH3BP4 TP53 TP53 SFRP2 SFRP2 LOC102129147 LOC102129147 ST20 ST20 BMP10 BMP10 GAS2L1 GAS2L1 ARHGAP4 ARHGAP4 ENSMFAP00000038954 ENSMFAP00000038954 ENSMFAP00000038957 ENSMFAP00000038957 ENPP1 ENPP1 SEMA5A SEMA5A CAV3 CAV3 SIRT1 SIRT1 CDKN2AIP CDKN2AIP GSK3A GSK3A MYOZ1 MYOZ1 EAF2 EAF2 ENSMFAP00000040580 ENSMFAP00000040580 ENSMFAP00000040832 ENSMFAP00000040832 TMPRSS4 TMPRSS4 KIAA0319 KIAA0319 DNAJB2 DNAJB2 SEMA6A SEMA6A PPP1R9B PPP1R9B ACVRL1 ACVRL1 ENSMFAP00000042512 ENSMFAP00000042512 SCGB3A1 SCGB3A1 IGFBP5 IGFBP5 DRAXIN DRAXIN FOXP1 FOXP1 MSX1 MSX1 ENSMFAP00000043662 ENSMFAP00000043662 TOMM70 TOMM70 NME6 NME6 WWC1 WWC1 PLXNA3 PLXNA3 OSGIN1 OSGIN1 MINAR1 MINAR1 CCDC144NL CCDC144NL HYAL2 HYAL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RB1RB transcriptional corepressor 1. (928 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
MYL10Myosin light chain 10. (177 aa)
OSTNProcessed Osteocrin; Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience. Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (By similarity). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity). Belongs to the Osteocrin family. (133 aa)
TRIM46Tripartite motif containing 46. (759 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (760 aa)
EPHA7EPH receptor A7. (998 aa)
ENSMFAP00000001456Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (668 aa)
JADE1Jade family PHD finger 1. (843 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (836 aa)
TNRTenascin R. (1358 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A regulatory subunit A. (589 aa)
GDF9Growth differentiation factor 9. (455 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSMFAP00000004047S1 motif domain-containing protein. (248 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (783 aa)
LOC102126088ANK_REP_REGION domain-containing protein. (584 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ENSMFAP00000005291Uncharacterized protein. (436 aa)
PMLPromyelocytic leukemia. (882 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
ENSMFAP00000005456Prohibitin. (239 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SEMA5BSemaphorin 5B. (1095 aa)
MT1FMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
RAI1Retinoic acid induced 1. (1922 aa)
ENSMFAP00000005860Prohibitin. (194 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
BST2Bone marrow stromal cell antigen 2. (182 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1036 aa)
ST7LSuppression of tumorigenicity 7 like. (544 aa)
ENSMFAP00000007313Prohibitin. (196 aa)
DAB2DAB adaptor protein 2. (770 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SPHK2Sphingosine kinase 2. (653 aa)
BCL6BCL6 transcription repressor. (708 aa)
PLAC8Placenta associated 8. (113 aa)
ING4Inhibitor of growth protein. (255 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
STK3Serine/threonine kinase 3. (519 aa)
SLIT3Slit guidance ligand 3. (1480 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
SERTAD3SERTA domain containing 3. (196 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
LOC102124074Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
ENSMFAP00000010204ANK_REP_REGION domain-containing protein. (270 aa)
BCL2BCL2 apoptosis regulator. (242 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
VGLL4Vestigial like family member 4. (296 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (838 aa)
ENSMFAP00000011899Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (49 aa)
ADRB2Adrenergic receptor beta 2. (415 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
OSGIN2Oxidative stress induced growth inhibitor family member 2. (546 aa)
CAPRIN2Caprin family member 2. (1113 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
CCN3Cellular communication network factor 3. (370 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (376 aa)
PPT1Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (By similarity). (335 aa)
MT3Metallothionein-3; Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity). (113 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
RNF6Ring finger protein 6. (701 aa)
ENSMFAP00000014215Anti_prolifrtn domain-containing protein. (161 aa)
ENSMFAP00000014396Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (69 aa)
SERTAD1SERTA domain containing 1. (236 aa)
ENSMFAP00000014629annotation not available (61 aa)
CCDC85BCoiled-coil domain containing 85B. (202 aa)
PSRC1Proline/serine-rich coiled-coil protein 1. (333 aa)
STK4Serine/threonine kinase 4. (487 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
DACT3Uncharacterized protein. (181 aa)
WT1WT1 transcription factor. (513 aa)
ADRB1Adrenoceptor beta 1. (438 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (264 aa)
SOCS2Suppressor of cytokine signaling 2. (212 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (747 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (782 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (478 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
CTDP1CTD phosphatase subunit 1. (1022 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
LOC102139102Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (72 aa)
DIP2BDisco interacting protein 2 homolog B. (1545 aa)
GDF2Growth differentiation factor 2. (429 aa)
LOC102141421Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (86 aa)
LOC102140106Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
PTCH1Patched 1. (1398 aa)
NPPBNatriuretic peptide B. (132 aa)
DSPPDentin sialophosphoprotein. (1216 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ENSMFAP00000018577Prohibitin. (236 aa)
HIF1AUncharacterized protein. (831 aa)
IFRD2Uncharacterized protein. (510 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
SAV1Uncharacterized protein. (384 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
LOC101867369Hypothetical protein. (61 aa)
HRGHistidine rich glycoprotein. (525 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (745 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
NPR1Guanylate cyclase. (1061 aa)
SPARTSpartin. (666 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (341 aa)
ENSMFAP00000020785ANK_REP_REGION domain-containing protein. (366 aa)
FSTL4Follistatin like 4. (842 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
BBC3BCL2 binding component 3. (261 aa)
DCCDCC netrin 1 receptor. (1447 aa)
MT1XMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
ING5Inhibitor of growth family member 5. (252 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
ENSMFAP00000021335Prohibitin. (247 aa)
FRZBFrizzled related protein. (325 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
DUSP10Dual specificity phosphatase 10. (488 aa)
LOC102115428ANK_REP_REGION domain-containing protein. (278 aa)
MT1GMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
SIPA1Signal-induced proliferation-associated 1. (1042 aa)
TCHPUncharacterized protein. (264 aa)
ENSMFAP00000022083Uncharacterized protein. (134 aa)
PTK6Tyrosine-protein kinase. (451 aa)
EI24EI24 autophagy associated transmembrane protein. (349 aa)
SESN2Sestrin 2. (480 aa)
ENSMFAP00000022848Uncharacterized protein. (81 aa)
SPAG9Sperm associated antigen 9. (1293 aa)
ENSMFAP00000022925Prohibitin. (196 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
G6PDGlucose-6-phosphate dehydrogenase. (560 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (468 aa)
RACK1Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC- mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits [...] (393 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (749 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
TP53TG5TP53 target 5. (290 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
GNASGNAS complex locus. (1023 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
LOC102137984Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
SOX17Uncharacterized protein. (416 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
CGRRF1RING-type domain-containing protein. (332 aa)
MAGMyelin associated glycoprotein. (626 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
ING1Inhibitor of growth protein. (417 aa)
ADAM15ADAM metallopeptidase domain 15. (863 aa)
LGMNLegumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). (433 aa)
CRLF3Cytokine receptor like factor 3. (442 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (470 aa)
TBX5T-box transcription factor 5. (518 aa)
CDHR2Cadherin related family member 2. (1310 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
RYKReceptor like tyrosine kinase. (585 aa)
PRDM11PR/SET domain 11. (1229 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (962 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in [...] (163 aa)
IFRD1Uncharacterized protein. (452 aa)
DCBLD2Discoidin, CUB and LCCL domain containing 2. (775 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
RERGRAS like estrogen regulated growth inhibitor. (199 aa)
WWC2WW and C2 domain containing 2. (1217 aa)
C10orf90Chromosome 10 open reading frame 90. (796 aa)
FXNFrataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). (210 aa)
ULK1Unc-51 like autophagy activating kinase 1. (967 aa)
PHBProhibitin. (272 aa)
WFDC1WAP four-disulfide core domain 1. (192 aa)
MYL2Myosin light chain 2. (166 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1200 aa)
FHL1Four and a half LIM domains 1. (339 aa)
DCUN1D3DCN1-like protein. (304 aa)
MT1AMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (59 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TLL2Metalloendopeptidase. (1015 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
MAP2Microtubule-associated protein. (1827 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (676 aa)
RTN4RReticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Pla [...] (522 aa)
HYAL1Hyaluronidase. (435 aa)
RTN4Reticulon. (1193 aa)
MT1MMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GDF15Growth/differentiation factor 15; Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling (By similarity). (308 aa)
ENSMFAP00000034846Uncharacterized protein. (131 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1279 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (526 aa)
WWC3WWC family member 3. (1128 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSMFAP00000035602Uncharacterized protein. (178 aa)
TSPYL2Testis-specific Y-encoded-like protein 2; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression (By similarity). (695 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1; Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targete [...] (352 aa)
RBBP7Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and [...] (469 aa)
MT2AMetallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. (61 aa)
FLCNFolliculin. (579 aa)
SERTAD2SERTA domain containing 2. (320 aa)
NDRG3NDRG family member 3. (317 aa)
NTN1Netrin 1. (598 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1569 aa)
ENSMFAP00000037410Uncharacterized protein. (137 aa)
INHBAInhibin subunit beta A. (426 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
SH3BP4SH3 domain binding protein 4. (963 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
LOC102129147RING-type domain-containing protein. (331 aa)
ST20Uncharacterized protein. (78 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
GAS2L1Growth arrest specific 2 like 1. (681 aa)
ARHGAP4Rho GTPase activating protein 4. (946 aa)
ENSMFAP00000038954Uncharacterized protein. (259 aa)
ENSMFAP00000038957Uncharacterized protein. (142 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (925 aa)
SEMA5ASemaphorin 5A. (1074 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SIRT1Sirtuin 1. (743 aa)
CDKN2AIPCDKN2A interacting protein. (580 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
MYOZ1Myozenin 1. (299 aa)
EAF2ELL associated factor 2. (263 aa)
ENSMFAP00000040580Uncharacterized protein. (507 aa)
ENSMFAP00000040832Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
TMPRSS4Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (437 aa)
KIAA0319KIAA0319. (1072 aa)
DNAJB2J domain-containing protein. (324 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (818 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ENSMFAP00000042512DCN1-like protein. (289 aa)
SCGB3A1Secretoglobin family 3A member 1. (102 aa)
IGFBP5Uncharacterized protein. (272 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (348 aa)
FOXP1Forkhead box P1. (693 aa)
MSX1Msh homeobox 1. (303 aa)
ENSMFAP00000043662Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (60 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (608 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
WWC1WW and C2 domain containing 1. (1119 aa)
PLXNA3Plexin A3. (1871 aa)
OSGIN1Oxidative stress induced growth inhibitor 1. (555 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (916 aa)
CCDC144NLUncharacterized protein. (1391 aa)
HYAL2Hyaluronidase. (473 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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