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F2 F2 PRSS57 PRSS57 PRSS12 PRSS12 PRSS35 PRSS35 MASP2 MASP2 TMPRSS11B TMPRSS11B LOC102147021 LOC102147021 PRSS55 PRSS55 TMPRSS12 TMPRSS12 ENSMFAP00000011235 ENSMFAP00000011235 CELA3B CELA3B PRSS37 PRSS37 PRSS22 PRSS22 CTSG CTSG LOC102127568 LOC102127568 HP HP HGFAC HGFAC KLK4 KLK4 PRSS53 PRSS53 PRSS33 PRSS33 KLK1 KLK1 C1RL C1RL PAMR1 PAMR1 TMPRSS11F TMPRSS11F OVCH1 OVCH1 PRSS46 PRSS46 LOC102132890 LOC102132890 LOC102127372 LOC102127372 ENSMFAP00000009659 ENSMFAP00000009659 CORIN CORIN KLK8 KLK8 KLK13 KLK13 TMPRSS11A TMPRSS11A ENSMFAP00000043697 ENSMFAP00000043697 PRSS58 PRSS58 KLK3 KLK3 PRSS41 PRSS41 PRSS36 PRSS36 C1R C1R PRSS54 PRSS54 CMA1 CMA1 PLAU PLAU KLK14 KLK14 OVCH2 OVCH2 GZMK GZMK HABP2 HABP2 ACR ACR KLK6 KLK6 MST1 MST1 LOC102131765 LOC102131765 TMPRSS3 TMPRSS3 AZU1 AZU1 CTRB2 CTRB2 MASP1 MASP1 KLK5 KLK5 PROZ PROZ ENSMFAP00000029987 ENSMFAP00000029987 ENSMFAP00000029985 ENSMFAP00000029985 LOC102139474 LOC102139474 PLAT PLAT CTRL CTRL PRSS48 PRSS48 PRSS38 PRSS38 KLKB1 KLKB1 F9 F9 C1S C1S TMPRSS2 TMPRSS2 PROC PROC PRSS21 PRSS21 TMPRSS15 TMPRSS15 CELA1 CELA1 KLK10 KLK10 LOC102141414 LOC102141414 TPSD1 TPSD1 F10 F10 KLK15 KLK15 CELA2B CELA2B TMPRSS7 TMPRSS7 LOC102139613 LOC102139613 LOC102135038 LOC102135038 TMPRSS13 TMPRSS13 TMPRSS6 TMPRSS6 TMPRSS11D TMPRSS11D TPSG1 TPSG1 KLK9 KLK9 ST14 ST14 PRSS27 PRSS27 PRSS45P PRSS45P F12 F12 KLK11 KLK11 CFI CFI PRSS8 PRSS8 ENSMFAP00000000657 ENSMFAP00000000657 PLG PLG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (620 aa)
PRSS57Serine protease 57; Belongs to the peptidase S1 family. (256 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (875 aa)
PRSS35Serine protease 35. (412 aa)
MASP2Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa)
TMPRSS11BTransmembrane protease serine; Belongs to the peptidase S1 family. (416 aa)
LOC102147021Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (262 aa)
PRSS55Serine protease 55; Belongs to the peptidase S1 family. (352 aa)
TMPRSS12Transmembrane serine protease 12; Belongs to the peptidase S1 family. (348 aa)
ENSMFAP00000011235Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (230 aa)
CELA3BPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (270 aa)
PRSS37Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system; Belongs to the peptidase S1 family. (235 aa)
PRSS22Serine protease 22; Belongs to the peptidase S1 family. (261 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
LOC102127568Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (269 aa)
HPPeptidase S1 domain-containing protein. (426 aa)
HGFACHGF activator. (657 aa)
KLK4Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (254 aa)
PRSS53Serine protease 53; Belongs to the peptidase S1 family. (564 aa)
PRSS33Serine protease 33; Belongs to the peptidase S1 family. (279 aa)
KLK1Kallikrein-1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (258 aa)
C1RLComplement C1r subcomponent like; Belongs to the peptidase S1 family. (481 aa)
PAMR1Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family. (737 aa)
TMPRSS11FTransmembrane protease serine; Belongs to the peptidase S1 family. (438 aa)
OVCH1Ovochymase 1; Belongs to the peptidase S1 family. (1126 aa)
PRSS46Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (174 aa)
LOC102132890Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (262 aa)
LOC102127372Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (261 aa)
ENSMFAP00000009659Peptidase S1 domain-containing protein. (148 aa)
CORINCorin, serine peptidase. (1111 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (294 aa)
KLK13Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (277 aa)
TMPRSS11ATransmembrane protease serine; Belongs to the peptidase S1 family. (421 aa)
ENSMFAP00000043697Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (243 aa)
PRSS58Serine protease 58; Belongs to the peptidase S1 family. (241 aa)
KLK3Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. (261 aa)
PRSS41Serine protease 41; Belongs to the peptidase S1 family. (318 aa)
PRSS36Polyserase-2; Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1. Belongs to the peptidase S1 family. (853 aa)
C1RComplement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family. (698 aa)
PRSS54Serine protease 54. (343 aa)
CMA1Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. (252 aa)
PLAUPlasminogen activator, urokinase. (430 aa)
KLK14Kallikrein related peptidase 14; Belongs to the peptidase S1 family. (267 aa)
OVCH2Ovochymase 2 (gene/pseudogene); Belongs to the peptidase S1 family. (554 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (264 aa)
HABP2Hyaluronan binding protein 2. (560 aa)
ACRAcrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (406 aa)
KLK6Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (244 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
LOC102131765Haptoglobin-related protein; Belongs to the peptidase S1 family. (347 aa)
TMPRSS3Transmembrane serine protease 3; Belongs to the peptidase S1 family. (454 aa)
AZU1Azurocidin 1. (250 aa)
CTRB2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (263 aa)
MASP1Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (730 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (291 aa)
PROZProtein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family. (422 aa)
ENSMFAP00000029987Peptidase S1 domain-containing protein. (386 aa)
ENSMFAP00000029985Peptidase S1 domain-containing protein. (220 aa)
LOC102139474Kallikrein related peptidase 2; Belongs to the peptidase S1 family. (223 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
CTRLChymotrypsin like; Belongs to the peptidase S1 family. (264 aa)
PRSS48Serine protease 48; Belongs to the peptidase S1 family. (329 aa)
PRSS38Serine protease 38; Belongs to the peptidase S1 family. (326 aa)
KLKB1Kallikrein B1; Belongs to the peptidase S1 family. (638 aa)
F9Coagulation factor IX. (461 aa)
C1SUncharacterized protein; Belongs to the peptidase S1 family. (688 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (529 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (462 aa)
PRSS21Serine protease 21; Belongs to the peptidase S1 family. (314 aa)
TMPRSS15Transmembrane serine protease 15; Belongs to the peptidase S1 family. (1019 aa)
CELA1Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (261 aa)
KLK10Kallikrein related peptidase 10; Belongs to the peptidase S1 family. (276 aa)
LOC102141414Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (307 aa)
TPSD1Tryptase delta 1; Belongs to the peptidase S1 family. (282 aa)
F10Coagulation factor X. (488 aa)
KLK15Kallikrein related peptidase 15; Belongs to the peptidase S1 family. (255 aa)
CELA2BChymotrypsin like elastase 2B; Belongs to the peptidase S1 family. (236 aa)
TMPRSS7Transmembrane serine protease 7; Belongs to the peptidase S1 family. (843 aa)
LOC102139613Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (282 aa)
LOC102135038Uncharacterized protein; Belongs to the peptidase S1 family. (664 aa)
TMPRSS13Transmembrane serine protease 13; Belongs to the peptidase S1 family. (577 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (821 aa)
TMPRSS11DTransmembrane protease serine; Belongs to the peptidase S1 family. (418 aa)
TPSG1Tryptase gamma 1; Belongs to the peptidase S1 family. (321 aa)
KLK9Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
PRSS27Serine protease 27; Belongs to the peptidase S1 family. (291 aa)
PRSS45PSerine protease 45, pseudogene; Belongs to the peptidase S1 family. (261 aa)
F12Coagulation factor XII. (615 aa)
KLK11Kallikrein related peptidase 11; Belongs to the peptidase S1 family. (282 aa)
CFIUncharacterized protein. (161 aa)
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (343 aa)
ENSMFAP00000000657Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (268 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (811 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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