STRINGSTRING
ASPM ASPM SKA1 SKA1 CIP2A CIP2A NUF2 NUF2 CDC20B CDC20B AURKB AURKB BUB3 BUB3 DLGAP5 DLGAP5 SPC24 SPC24 CDCA3 CDCA3 SPAG5 SPAG5 KNTC1 KNTC1 TOP2A TOP2A H9H3J4_MACMU H9H3J4_MACMU ARHGAP11A ARHGAP11A NUSAP1 NUSAP1 ERCC6L ERCC6L CDCA8 CDCA8 CENPF CENPF CENPA CENPA PBK PBK SKA3 SKA3 PLK1 PLK1 CKAP2 CKAP2 NDC80 NDC80 CKAP2L CKAP2L HJURP HJURP ESPL1 ESPL1 ZWINT ZWINT KIF11 KIF11 CCNB1 CCNB1 CENPE CENPE CDK1 CDK1 AURKA AURKA SGO1 SGO1 ECT2 ECT2 CDC20 CDC20 PRC1 PRC1 MELK MELK BIRC5 BIRC5 BUB1B BUB1B CDCA2 CDCA2 NSL1 NSL1 BUB1 BUB1 NEK2 NEK2 KNL1 KNL1 KIF20A KIF20A PLK2 PLK2 ENSMMUP00000053583 ENSMMUP00000053583 SKA2 SKA2 KIF23 KIF23 CCNB2 CCNB2 MKI67 MKI67 KNSTRN KNSTRN LOC693699 LOC693699 PTTG1 PTTG1 MAD1L1 MAD1L1 TACC3 TACC3 MIS12 MIS12 TPX2 TPX2 DSN1 DSN1 MAD2L1 MAD2L1 SPC25 SPC25 CEP55 CEP55 INCENP INCENP RACGAP1 RACGAP1 SPDL1 SPDL1 TTK TTK SGO2 SGO2 ZWILCH ZWILCH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3476 aa)
SKA1Spindle and kinetochore associated complex subunit 1. (255 aa)
CIP2ACell proliferation regulating inhibitor of protein phosphatase 2A. (906 aa)
NUF2Kinetochore protein Nuf2. (464 aa)
CDC20BCell division cycle 20B. (518 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (345 aa)
BUB3WD_REPEATS_REGION domain-containing protein. (369 aa)
DLGAP5DLG associated protein 5. (850 aa)
SPC24SPC24 component of NDC80 kinetochore complex. (197 aa)
CDCA3Cell division cycle-associated protein 3. (268 aa)
SPAG5Sperm associated antigen 5. (1195 aa)
KNTC1Kinetochore associated 1. (2209 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
H9H3J4_MACMUUncharacterized protein. (142 aa)
ARHGAP11ARho GTPase activating protein 11A. (1023 aa)
NUSAP1Nucleolar and spindle associated protein 1. (423 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1252 aa)
CDCA8Cell division cycle associated 8. (280 aa)
CENPFCentromere protein F. (3113 aa)
CENPACentromere protein A. (138 aa)
PBKPDZ binding kinase. (323 aa)
SKA3Spindle and kinetochore-associated protein 3 isoform 1. (412 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
CKAP2Cytoskeleton associated protein 2. (682 aa)
NDC80Kinetochore protein NDC80 homolog. (642 aa)
CKAP2LCytoskeleton associated protein 2 like. (742 aa)
HJURPHolliday junction recognition protein. (728 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2120 aa)
ZWINTZW10 interacting kinetochore protein. (277 aa)
KIF11Kinesin-like protein KIF11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1056 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (433 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2701 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
SGO1Shugoshin 1. (554 aa)
ECT2Epithelial cell transforming 2. (958 aa)
CDC20Cell division cycle protein 20 homolog. (499 aa)
PRC1Uncharacterized protein. (624 aa)
MELKNon-specific serine/threonine protein kinase. (651 aa)
BIRC5Baculoviral IAP repeat-containing protein 5 isoform 1. (142 aa)
BUB1BBUB1 mitotic checkpoint serine/threonine kinase B. (1063 aa)
CDCA2Cell division cycle associated 2. (1023 aa)
NSL1NSL1 component of MIS12 kinetochore complex. (398 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1085 aa)
NEK2Serine/threonine-protein kinase Nek2 isoform 1. (445 aa)
KNL1Kinetochore scaffold 1. (2316 aa)
KIF20AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (890 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
ENSMMUP00000053583HORMA domain-containing protein. (205 aa)
SKA2Spindle and kinetochore-associated protein 2 isoform 1. (121 aa)
KIF23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (974 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
MKI67Marker of proliferation Ki-67. (3249 aa)
KNSTRNKinetochore localized astrin (SPAG5) binding protein. (316 aa)
LOC693699CS domain-containing protein. (157 aa)
PTTG1Securin. (202 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
TACC3Transforming acidic coiled-coil containing protein 3. (817 aa)
MIS12Protein MIS12 homolog. (205 aa)
TPX2TPX2 microtubule nucleation factor. (757 aa)
DSN1Kinetochore-associated protein DSN1 homolog isoform 1. (354 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
SPC25Kinetochore protein Spc25. (224 aa)
CEP55Centrosomal protein 55. (464 aa)
INCENPInner centromere protein. (900 aa)
RACGAP1Rac GTPase-activating protein 1. (632 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (622 aa)
TTKTTK protein kinase. (860 aa)
SGO2Shugoshin 2. (1258 aa)
ZWILCHZwilch kinetochore protein. (591 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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