(19 nodes) Stem cell division network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	THOC2	THO complex subunit 2. (1593 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	ZBTB16	Uncharacterized protein. (673 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	ING2	Inhibitor of growth protein. (280 aa)
	GNL3	Guanine nucleotide-binding protein-like 3 isoform 1. (549 aa)
	ESRRB	Estrogen related receptor beta. (438 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	WWTR1	WW domain containing transcription regulator 1. (432 aa)
	CUL3	Cullin-3; Belongs to the cullin family. (768 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa)
	TIAL1	TIA1 cytotoxic granule associated RNA binding protein like 1. (375 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
	SAMD9L	Sterile alpha motif domain containing 9 like. (1585 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	HOXB4	Homeobox B4. (251 aa)
	SAMD9	Sterile alpha motif domain containing 9. (1588 aa)
	ZFP36L2	Zinc finger protein 36, C3H1 type-like 2. (492 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL3	ZBTB16	ENSMMUP00000037501	ENSMMUP00000009286	Cullin-3; Belongs to the cullin family.	Uncharacterized protein.	0.631
FZD7	WNT3A	ENSMMUP00000041518	ENSMMUP00000006513	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.898
FZD7	WNT7A	ENSMMUP00000041518	ENSMMUP00000024267	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.950
NOTCH1	WNT3A	ENSMMUP00000022401	ENSMMUP00000006513	Notch receptor 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.407
WNT3A	FZD7	ENSMMUP00000006513	ENSMMUP00000041518	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	0.898
WNT3A	NOTCH1	ENSMMUP00000006513	ENSMMUP00000022401	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Notch receptor 1.	0.407
WNT3A	WNT7A	ENSMMUP00000006513	ENSMMUP00000024267	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.428
WNT7A	FZD7	ENSMMUP00000024267	ENSMMUP00000041518	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	0.950
WNT7A	WNT3A	ENSMMUP00000024267	ENSMMUP00000006513	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.428
ZBTB16	CUL3	ENSMMUP00000009286	ENSMMUP00000037501	Uncharacterized protein.	Cullin-3; Belongs to the cullin family.	0.631