(42 nodes) Extracellular matrix disassembly network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ELANE	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (263 aa)
	TMPRSS6	Transmembrane serine protease 6. (970 aa)
	LOC114677048	Serine protease 2; Belongs to the peptidase S1 family. (246 aa)
	PRSS2	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (295 aa)
	WDR72	WD repeat domain 72. (1120 aa)
	MMP1	Matrix metallopeptidase 1. (469 aa)
	ADAMTS15	ADAM metallopeptidase with thrombospondin type 1 motif 15. (950 aa)
	MMP7	Matrix metallopeptidase 7. (270 aa)
	MMP3	Matrix metallopeptidase 3. (477 aa)
	MMP12	Matrix metallopeptidase 12. (470 aa)
	MMP13	Matrix metallopeptidase 13. (471 aa)
	CTSG	Cathepsin G; Belongs to the peptidase S1 family. (255 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
	EXOC8	Exocyst complex component 8. (725 aa)
	NOXO1	NADPH oxidase organizer 1. (378 aa)
	MMP11	Matrix metallopeptidase 11. (488 aa)
	SH3PXD2B	SH3 and PX domains 2B. (937 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (354 aa)
	MMP20	Uncharacterized protein. (483 aa)
	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5. (930 aa)
	FLOT1	Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (439 aa)
	LAMC1	Laminin subunit gamma-1. (1608 aa)
	MMP9	Uncharacterized protein. (707 aa)
	LCP1	Lymphocyte cytosolic protein 1. (636 aa)
	MMP10	Matrix metallopeptidase 10. (476 aa)
	CTSV	Uncharacterized protein; Belongs to the peptidase C1 family. (355 aa)
	ADAM8	ADAM metallopeptidase domain 8. (823 aa)
	ADAM15	ADAM metallopeptidase domain 15. (919 aa)
	KLK4	Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (254 aa)
	HPN	Hepsin; Belongs to the peptidase S1 family. (471 aa)
	PRSS1	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
	MMP2	72 kDa type IV collagenase isoform a preproprotein. (660 aa)
	KIF9	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (715 aa)
	MMP19	Matrix metallopeptidase 19. (508 aa)
	KLK7	Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (728 aa)
	KLK5	Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (291 aa)
	PBXIP1	PBX homeobox interacting protein 1. (769 aa)
	MMP8	Matrix metallopeptidase 8. (467 aa)
	ADAM10	ADAM metallopeptidase domain 10. (783 aa)
	MMP15	Matrix metallopeptidase 15. (671 aa)
	ENG	Endoglin. (672 aa)
	WASHC1	WASH complex subunit 1. (478 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	FURIN	ENSMMUP00000075812	ENSMMUP00000006194	ADAM metallopeptidase domain 10.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.451
ADAM10	MMP9	ENSMMUP00000075812	ENSMMUP00000021747	ADAM metallopeptidase domain 10.	Uncharacterized protein.	0.449
ADAM15	SH3PXD2B	ENSMMUP00000030724	ENSMMUP00000013206	ADAM metallopeptidase domain 15.	SH3 and PX domains 2B.	0.621
ADAMTS15	MMP1	ENSMMUP00000004391	ENSMMUP00000002724	ADAM metallopeptidase with thrombospondin type 1 motif 15.	Matrix metallopeptidase 1.	0.486
ADAMTS15	MMP10	ENSMMUP00000004391	ENSMMUP00000028662	ADAM metallopeptidase with thrombospondin type 1 motif 15.	Matrix metallopeptidase 10.	0.487
ADAMTS15	MMP19	ENSMMUP00000004391	ENSMMUP00000054520	ADAM metallopeptidase with thrombospondin type 1 motif 15.	Matrix metallopeptidase 19.	0.690
ADAMTS5	MMP13	ENSMMUP00000017606	ENSMMUP00000005676	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Matrix metallopeptidase 13.	0.812
ADAMTS5	MMP3	ENSMMUP00000017606	ENSMMUP00000005671	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Matrix metallopeptidase 3.	0.711
ADAMTS5	MMP9	ENSMMUP00000017606	ENSMMUP00000021747	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Uncharacterized protein.	0.464
CTSG	CTSS	ENSMMUP00000005891	ENSMMUP00000013979	Cathepsin G; Belongs to the peptidase S1 family.	Cathepsin S; Belongs to the peptidase C1 family.	0.522
CTSG	ELANE	ENSMMUP00000005891	ENSMMUP00000012657	Cathepsin G; Belongs to the peptidase S1 family.	Elastase, neutrophil expressed; Belongs to the peptidase S1 family.	0.986
CTSG	MMP7	ENSMMUP00000005891	ENSMMUP00000004544	Cathepsin G; Belongs to the peptidase S1 family.	Matrix metallopeptidase 7.	0.416
CTSG	MMP8	ENSMMUP00000005891	ENSMMUP00000073817	Cathepsin G; Belongs to the peptidase S1 family.	Matrix metallopeptidase 8.	0.504
CTSG	MMP9	ENSMMUP00000005891	ENSMMUP00000021747	Cathepsin G; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.839
CTSS	CTSG	ENSMMUP00000013979	ENSMMUP00000005891	Cathepsin S; Belongs to the peptidase C1 family.	Cathepsin G; Belongs to the peptidase S1 family.	0.522
CTSS	CTSV	ENSMMUP00000013979	ENSMMUP00000030251	Cathepsin S; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.413
CTSS	ELANE	ENSMMUP00000013979	ENSMMUP00000012657	Cathepsin S; Belongs to the peptidase C1 family.	Elastase, neutrophil expressed; Belongs to the peptidase S1 family.	0.733
CTSS	FURIN	ENSMMUP00000013979	ENSMMUP00000006194	Cathepsin S; Belongs to the peptidase C1 family.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.847
CTSS	LOC114677048	ENSMMUP00000013979	ENSMMUP00000000366	Cathepsin S; Belongs to the peptidase C1 family.	Serine protease 2; Belongs to the peptidase S1 family.	0.445
CTSS	MMP12	ENSMMUP00000013979	ENSMMUP00000005673	Cathepsin S; Belongs to the peptidase C1 family.	Matrix metallopeptidase 12.	0.553