STRINGSTRING
WDR59 WDR59 ITFG2 ITFG2 IMPACT IMPACT MAPK8 MAPK8 NPRL3 NPRL3 GCN1 GCN1 EIF2AK3 EIF2AK3 SESN3 SESN3 MAPK1 MAPK1 KPTN KPTN RRAGA RRAGA SESN2 SESN2 EIF2S1 EIF2S1 PRKD1 PRKD1 RRAGC RRAGC SZT2 SZT2 TFEB TFEB ATF3 ATF3 MAPK10 MAPK10 BMT2 BMT2 MAP1LC3A MAP1LC3A MIOS MIOS ATF2 ATF2 EIF2AK2 EIF2AK2 RRAGD RRAGD MAP3K5 MAP3K5 MAPK3 MAPK3 ENSMMUP00000053874 ENSMMUP00000053874 WDR24 WDR24 EIF2AK4 EIF2AK4 RNF152 RNF152 NPRL2 NPRL2 RRAGB RRAGB ATF4 ATF4 C11H12orf66 C11H12orf66 MTOR MTOR DAP DAP FLCN FLCN SESN1 SESN1 CDKN1A CDKN1A DAPL1 DAPL1 ENSMMUP00000078057 ENSMMUP00000078057 RNF167 RNF167
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WDR59WD repeat domain 59. (1001 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (472 aa)
IMPACTProtein IMPACT. (320 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
NPRL3Nitrogen permease regulator 3-like protein isoform 1. (569 aa)
GCN1TOG domain-containing protein. (2719 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
SESN3Sestrin-3. (492 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
KPTNKaptin, actin binding protein. (525 aa)
RRAGARas-related GTP-binding protein A. (313 aa)
SESN2Sestrin-2. (480 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
RRAGCRas related GTP binding C. (399 aa)
SZT2SZT2 subunit of KICSTOR complex. (3432 aa)
TFEBTranscription factor EB. (490 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3 isoform 1. (181 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
MAP1LC3AUncharacterized protein. (125 aa)
MIOSMeiosis regulator for oocyte development. (877 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (554 aa)
RRAGDRas-related GTP-binding protein D. (400 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1483 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSMMUP00000053874RWD domain-containing protein. (293 aa)
WDR24WD repeat domain 24. (790 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1694 aa)
RNF152RING finger protein 152. (203 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (411 aa)
RRAGBRas-related GTP-binding protein B long isoform. (374 aa)
ATF4BZIP domain-containing protein. (351 aa)
C11H12orf66Chromosome 11 C12orf66 homolog. (566 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
DAPDeath associated protein. (162 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (680 aa)
SESN1Sestrin 1. (567 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
DAPL1Death associated protein like 1. (107 aa)
ENSMMUP00000078057Uncharacterized protein. (116 aa)
RNF167RING-type domain-containing protein. (374 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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