Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAMTS1 | EREG | ENSMMUP00000017609 | ENSMMUP00000080811 | A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein. | Proepiregulin. | 0.435 |
| ADAMTS1 | MMP9 | ENSMMUP00000017609 | ENSMMUP00000021747 | A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein. | Uncharacterized protein. | 0.445 |
| ADAMTS1 | PTGS2 | ENSMMUP00000017609 | ENSMMUP00000022160 | A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein. | Prostaglandin-endoperoxide synthase 2. | 0.468 |
| ADAMTS1 | THBS1 | ENSMMUP00000017609 | ENSMMUP00000007925 | A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein. | Thrombospondin 1. | 0.418 |
| ADIPOQ | AKT1 | ENSMMUP00000055436 | ENSMMUP00000061388 | Adiponectin, C1Q and collagen domain containing. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.435 |
| ADIPOQ | APOE | ENSMMUP00000055436 | ENSMMUP00000048554 | Adiponectin, C1Q and collagen domain containing. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.588 |
| ADIPOQ | IGF1 | ENSMMUP00000055436 | ENSMMUP00000002988 | Adiponectin, C1Q and collagen domain containing. | Insulin like growth factor 1. | 0.680 |
| ADIPOQ | IL10 | ENSMMUP00000055436 | ENSMMUP00000031022 | Adiponectin, C1Q and collagen domain containing. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.619 |
| ADIPOQ | IL6 | ENSMMUP00000055436 | ENSMMUP00000049077 | Adiponectin, C1Q and collagen domain containing. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.825 |
| ADIPOQ | PPARGC1A | ENSMMUP00000055436 | ENSMMUP00000060440 | Adiponectin, C1Q and collagen domain containing. | PPARG coactivator 1 alpha. | 0.655 |
| ADIPOQ | TLR4 | ENSMMUP00000055436 | ENSMMUP00000039787 | Adiponectin, C1Q and collagen domain containing. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.483 |
| ADIPOQ | TNF | ENSMMUP00000055436 | ENSMMUP00000056761 | Adiponectin, C1Q and collagen domain containing. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.712 |
| AIF1 | IL10 | ENSMMUP00000074541 | ENSMMUP00000031022 | Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.411 |
| AIF1 | IL6 | ENSMMUP00000074541 | ENSMMUP00000049077 | Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.452 |
| AIF1 | NOX1 | ENSMMUP00000074541 | ENSMMUP00000005594 | Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). | NADPH oxidase 1. | 0.413 |
| AIF1 | TNF | ENSMMUP00000074541 | ENSMMUP00000056761 | Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.494 |
| AKT1 | ADIPOQ | ENSMMUP00000061388 | ENSMMUP00000055436 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Adiponectin, C1Q and collagen domain containing. | 0.435 |
| AKT1 | APOE | ENSMMUP00000061388 | ENSMMUP00000048554 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.592 |
| AKT1 | CDKN1A | ENSMMUP00000061388 | ENSMMUP00000077663 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Cyclin-dependent kinase inhibitor 1. | 0.978 |
| AKT1 | CDKN1B | ENSMMUP00000061388 | ENSMMUP00000065552 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Cyclin-dependent kinase inhibitor 1B. | 0.981 |
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