STRINGSTRING
IL4 IL4 CEBPB CEBPB GPER1 GPER1 RABGEF1 RABGEF1 APOE APOE SCRIB SCRIB GCLC GCLC FGL1 FGL1 IRF1 IRF1 TARM1 TARM1 TNFAIP3 TNFAIP3 MILR1 MILR1 AXL AXL PLA2G2D PLA2G2D ZC3H8 ZC3H8 BTK BTK TNFRSF14 TNFRSF14 CD274 CD274 ZBTB7B ZBTB7B DLG1 DLG1 SCGB1A1 SCGB1A1 NR1H3 NR1H3 LOXL3 LOXL3 LOC106993942 LOC106993942 BANK1 BANK1 HFE HFE TREM2 TREM2 ADGRF5 ADGRF5 TNFRSF21 TNFRSF21 IDO1 IDO1 SFRP1 SFRP1 PGLYRP2 PGLYRP2 SAMSN1 SAMSN1 GRN GRN TGFB1 TGFB1 IL10 IL10 LRRC32 LRRC32 PARP3 PARP3 FGG FGG IL2 IL2 NOS3 NOS3 BPI BPI H9H440_MACMU H9H440_MACMU BLK BLK IFNB1 IFNB1 RAG2 RAG2 LOC100427967 LOC100427967 CLNK CLNK ENPP3 ENPP3 TBC1D10C TBC1D10C VTCN1 VTCN1 THBD THBD ALOX12 ALOX12 SPN SPN CTLA4 CTLA4 CD84 CD84 PAWR PAWR CD37 CD37 NRARP NRARP TYRO3 TYRO3 CR1 CR1 FER FER ITCH ITCH LRFN5 LRFN5 IL4I1 IL4I1 JAK3 JAK3 SOCS1 SOCS1 IFNL1 IFNL1 PRKG1 PRKG1 ICOSLG ICOSLG ZC3H12A ZC3H12A PTPN6 PTPN6 GLMN GLMN MERTK MERTK INPP5D INPP5D BCR BCR CD74 CD74 TRIM2 TRIM2 LST1 LST1 MAMU-F MAMU-F PGLYRP1 PGLYRP1 FOXP3 FOXP3 PTEN PTEN INHA INHA IL20RB IL20RB PDE5A PDE5A FBXO7 FBXO7 SERPINE2 SERPINE2 CST7 CST7 HAVCR2 HAVCR2 TNFRSF13B TNFRSF13B PDGFA PDGFA THOC1 THOC1 HMGB3 HMGB3 CD9 CD9 CTSG CTSG ATM ATM CD300LF CD300LF KLF5 KLF5 UBASH3B UBASH3B RASSF5 RASSF5 SH2B3 SH2B3 GIMAP5 GIMAP5 ADAMTS18 ADAMTS18 IHH IHH RC3H1 RC3H1 SOCS5 SOCS5 BCL6 BCL6 TNFSF18 TNFSF18 RHBDD3 RHBDD3 IL13RA2 IL13RA2 GPNMB GPNMB DLG5 DLG5 HLX HLX SOCS6 SOCS6 TIGIT TIGIT NCKAP1L NCKAP1L ENSMMUP00000077416 ENSMMUP00000077416 BMP4 BMP4 TAFA3 TAFA3 ARG2 ARG2 INHBA INHBA NDFIP1 NDFIP1 GAL GAL LILRB4 LILRB4 KHK KHK PRKCD PRKCD C1QTNF6 C1QTNF6 RUNX1 RUNX1 VSIG4 VSIG4 ARG1 ARG1 CD80 CD80 TYROBP TYROBP LOC705334 LOC705334 LAX1 LAX1 CRTAM CRTAM TWSG1 TWSG1 LAG3 LAG3 PELI1 PELI1 CX3CL1 CX3CL1 CBLB CBLB ABAT ABAT MARCHF7 MARCHF7 FOXJ1 FOXJ1 C1QTNF1 C1QTNF1 SDC4 SDC4 CBFB CBFB CLEC4G CLEC4G PAG1 PAG1 ENSMMUP00000069441 ENSMMUP00000069441 IL4R IL4R VSIR VSIR GLI3 GLI3 PDCD1LG2 PDCD1LG2 FGL2 FGL2 PTPN2 PTPN2 PDGFB PDGFB FGR FGR MAD1L1 MAD1L1 SHH SHH NR1D1 NR1D1 LOC100426567 LOC100426567 PGLYRP3 PGLYRP3 ZBTB46 ZBTB46 ERBB2 ERBB2 PRNP PRNP ANXA1 ANXA1 LGALS3 LGALS3 SMAD7 SMAD7 FOXF1 FOXF1 LOC694781 LOC694781 TBX21 TBX21 CEACAM1 CEACAM1 LOC114669853 LOC114669853 ILDR2 ILDR2 CD200 CD200 RUNX3 RUNX3 CYGB CYGB LOC114674161 LOC114674161 MDK MDK RC3H2 RC3H2 ENSMMUP00000057803 ENSMMUP00000057803 PKN1 PKN1 SOX11 SOX11 DUSP22 DUSP22 PTPRC PTPRC SYT11 SYT11 LRRC1 LRRC1 PTPN22 PTPN22 LDLR LDLR LYN LYN CD86 CD86 ENSMMUP00000051444 ENSMMUP00000051444 TNFSF4 TNFSF4
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
GPER1G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor that binds to 17-beta- estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine [...] (375 aa)
RABGEF1Uncharacterized protein. (492 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
SCRIBScribble planar cell polarity protein. (1451 aa)
GCLCGlutamate--cysteine ligase catalytic subunit isoform a. (637 aa)
FGL1Fibrinogen like 1. (312 aa)
IRF1Interferon regulatory factor. (325 aa)
TARM1T cell-interacting, activating receptor on myeloid cells 1. (281 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (790 aa)
MILR1Mast cell immunoglobulin like receptor 1. (343 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
PLA2G2DPhospholipase A(2). (161 aa)
ZC3H8Zinc finger CCCH-type containing 8. (295 aa)
BTKTyrosine-protein kinase. (659 aa)
TNFRSF14TNF receptor superfamily member 14. (359 aa)
CD274CD274 molecule. (299 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (636 aa)
DLG1Disks large homolog 1 isoform 2; Belongs to the MAGUK family. (926 aa)
SCGB1A1Secretoglobin family 1A member 1. (91 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
LOC106993942Galectin. (356 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (797 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (291 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1383 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21. (655 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (403 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
PGLYRP2Peptidoglycan recognition protein 2. (576 aa)
SAMSN1Uncharacterized protein. (646 aa)
GRNGranulin precursor. (593 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
FGGFibrinogen gamma chain. (437 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
BPIBactericidal permeability increasing protein. (582 aa)
H9H440_MACMUMHC_I-like_Ag-recog domain-containing protein. (128 aa)
BLKTyrosine-protein kinase. (568 aa)
IFNB1Interferon beta 1. (187 aa)
RAG2Recombination activating 2. (532 aa)
LOC100427967Galectin. (355 aa)
CLNKCytokine dependent hematopoietic cell linker. (443 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (874 aa)
TBC1D10CCarabin. (446 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
THBDUncharacterized protein. (607 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
SPNSialophorin. (547 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM. (223 aa)
CD84CD84 molecule. (345 aa)
PAWRPro-apoptotic WT1 regulator. (341 aa)
CD37Tetraspanin. (281 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3. (890 aa)
CR1Complement C3b/C4b receptor 1 (Knops blood group). (2041 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
ITCHE3 ubiquitin-protein ligase. (918 aa)
LRFN5Leucine rich repeat and fibronectin type III domain containing 5. (750 aa)
IL4I1Amine oxidase. (589 aa)
JAK3Janus kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (602 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
IFNL1Interferon lambda 1. (202 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
ICOSLGUncharacterized protein. (305 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (626 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
MERTKMER proto-oncogene, tyrosine kinase. (1232 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1208 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform a. (294 aa)
TRIM2Transmembrane 131 like. (1724 aa)
LST1Leukocyte-specific transcript 1 protein; Possible role in modulating immune responses. Has an inhibitory effect on lymphocyte proliferation. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation (By similarity); Belongs to the LST1 family. (90 aa)
MAMU-FMamu class I histocompatibility antigen, alpha chain F; Involved in the presentation of foreign antigens to the immune system. (348 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (196 aa)
FOXP3Forkhead box P3. (539 aa)
PTENUncharacterized protein. (589 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
IL20RBFibronectin type-III domain-containing protein. (311 aa)
PDE5APhosphodiesterase. (875 aa)
FBXO7F-box only protein 7 isoform 1. (522 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
CST7Cystatin-F. (145 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (294 aa)
TNFRSF13BTNF receptor superfamily member 13B. (293 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (249 aa)
THOC1THO complex subunit 1. (657 aa)
HMGB3Uncharacterized protein. (201 aa)
CD9Tetraspanin. (228 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
CD300LFCD300 molecule like family member f. (306 aa)
KLF5Uncharacterized protein. (1062 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B. (649 aa)
RASSF5Ras association domain family member 5. (418 aa)
SH2B3SH2B adaptor protein 3. (570 aa)
GIMAP5AIG1-type G domain-containing protein. (338 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif 18. (1221 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
RC3H1Ring finger and CCCH-type domains 1. (1133 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
BCL6Uncharacterized protein. (735 aa)
TNFSF18Tumor necrosis factor ligand 2A. (199 aa)
RHBDD3Rhomboid domain-containing protein 3. (386 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (388 aa)
GPNMBPKD domain-containing protein. (556 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1948 aa)
HLXH2.0 like homeobox. (495 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
TIGITT cell immunoreceptor with Ig and ITIM domains. (245 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
ENSMMUP00000077416Uncharacterized protein. (113 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TAFA3Uncharacterized protein. (227 aa)
ARG2Arginase. (417 aa)
INHBAInhibin subunit beta A. (426 aa)
NDFIP1Uncharacterized protein. (228 aa)
GALGALANIN domain-containing protein. (166 aa)
LILRB4Leukocyte immunoglobulin like receptor B4. (423 aa)
KHKElastin microfibril interfacer 1. (1016 aa)
PRKCDProtein kinase C. (729 aa)
C1QTNF6C1q and TNF related 6. (278 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
VSIG4V-set and immunoglobulin domain containing 4. (404 aa)
ARG1Arginase. (322 aa)
CD80CD80 molecule. (288 aa)
TYROBPTYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (241 aa)
LOC705334Uncharacterized protein. (205 aa)
LAX1Uncharacterized protein. (398 aa)
CRTAMCytotoxic and regulatory T cell molecule. (401 aa)
TWSG1Twisted gastrulation protein-like protein 1. (223 aa)
LAG3Lymphocyte activating 3. (533 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
CBLBCbl proto-oncogene B. (982 aa)
ABAT4-aminobutyrate aminotransferase. (568 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (704 aa)
FOXJ1Forkhead box J1. (421 aa)
C1QTNF1C1q and TNF related 1. (423 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
CBFBCore-binding factor subunit beta isoform 1. (187 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (432 aa)
ENSMMUP00000069441TACI-CRD2 domain-containing protein. (109 aa)
IL4RInterleukin 4 receptor. (825 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
GLI3GLI family zinc finger 3. (1580 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (273 aa)
FGL2Fibrinogen like 2. (439 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
FGRTyrosine-protein kinase. (529 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
LOC100426567Uncharacterized protein. (638 aa)
PGLYRP3Peptidoglycan recognition protein 3. (341 aa)
ZBTB46Zinc finger and BTB domain containing 46. (588 aa)
ERBB2Receptor protein-tyrosine kinase. (1437 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
ANXA1Annexin. (367 aa)
LGALS3Galectin. (248 aa)
SMAD7Mothers against decapentaplegic homolog. (462 aa)
FOXF1Forkhead box F1. (432 aa)
LOC694781Galectin. (136 aa)
TBX21T-box transcription factor 21. (539 aa)
CEACAM1Uncharacterized protein. (525 aa)
LOC114669853Tyrosine-protein kinase. (1125 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (643 aa)
CD200Ig-like domain-containing protein. (300 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
CYGBGLOBIN domain-containing protein; Belongs to the globin family. (331 aa)
LOC114674161Galectin. (136 aa)
MDKMidkine. (143 aa)
RC3H2RING finger and CCCH-type zinc finger domain-containing protein 2 isoform 1. (1191 aa)
ENSMMUP00000057803MHC_I-like_Ag-recog domain-containing protein. (216 aa)
PKN1Protein kinase N1. (1013 aa)
SOX11Transcription factor SOX. (441 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (279 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
SYT11Synaptotagmin-11. (431 aa)
LRRC1Leucine-rich repeat-containing protein 1. (524 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
LDLRUncharacterized protein. (918 aa)
LYNTyrosine-protein kinase. (577 aa)
CD86CD86 molecule. (417 aa)
ENSMMUP00000051444Uncharacterized protein. (214 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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