(50 nodes) Cardiac muscle cell development network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BVES	Blood vessel epicardial substance. (360 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	AKAP13	A-kinase anchoring protein 13. (2899 aa)
	CXADR	CXADR Ig-like cell adhesion molecule. (361 aa)
	TBX18	T-box transcription factor 18. (556 aa)
	NEBL	Nebulette. (1028 aa)
	ALPK3	Uncharacterized protein. (1855 aa)
	TTN	Titin. (32000 aa)
	ALPK2	Alpha kinase 2. (2158 aa)
	SGCD	Sarcoglycan delta. (290 aa)
	MYO18B	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2565 aa)
	NRAP	Nebulin related anchoring protein. (1731 aa)
	NKX2-5	NK2 homeobox 5. (324 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (790 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	GATA4	GATA binding protein 4. (443 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (317 aa)
	NKX2-6	NK2 homeobox 6. (301 aa)
	PDLIM5	PDZ and LIM domain 5. (686 aa)
	PLEC	Plectin. (4862 aa)
	MYH11	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2139 aa)
	SRF	Serum response factor. (508 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (825 aa)
	LMNA	Prelamin-A/C isoform 1; Belongs to the intermediate filament family. (663 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
	ACTN2	Actinin alpha 2. (894 aa)
	DCUN1D2	Defective in cullin neddylation 1 domain containing 2. (1866 aa)
	MEF2A	Myocyte-specific enhancer factor 2A isoform 2. (503 aa)
	ADRA1A	Adrenoceptor alpha 1A. (445 aa)
	LRRC10B	Leucine rich repeat containing 10B. (292 aa)
	C10orf113	Chromosome 10 open reading frame 113. (155 aa)
	MYL2	Myosin light chain 2. (166 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (1014 aa)
	OBSL1	Obscurin like 1. (1896 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
	SORBS2	Sorbin and SH3 domain containing 2. (1246 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
	ISL1	ISL LIM homeobox 1. (413 aa)
	SHOX2	Short stature homeobox 2. (355 aa)
	CSRP3	Cysteine and glycine rich protein 3. (253 aa)
	LRRC10	Leucine-rich repeat-containing protein 10. (279 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	FHOD3	Uncharacterized protein. (1655 aa)
	PROX1	Prospero homeobox protein 1. (737 aa)
	FHL2	Four and a half LIM domains 2. (396 aa)
	SLC8A1	J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	CSRP3	ENSMMUP00000046341	ENSMMUP00000067509	Actinin alpha 2.	Cysteine and glycine rich protein 3.	0.723
ACTN2	LMNA	ENSMMUP00000046341	ENSMMUP00000038777	Actinin alpha 2.	Prelamin-A/C isoform 1; Belongs to the intermediate filament family.	0.415
ACTN2	MYH11	ENSMMUP00000046341	ENSMMUP00000032609	Actinin alpha 2.	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.465
ACTN2	MYL2	ENSMMUP00000046341	ENSMMUP00000058528	Actinin alpha 2.	Myosin light chain 2.	0.683
ACTN2	MYO18B	ENSMMUP00000046341	ENSMMUP00000004443	Actinin alpha 2.	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.445
ACTN2	NEBL	ENSMMUP00000046341	ENSMMUP00000013884	Actinin alpha 2.	Nebulette.	0.552
ACTN2	NRAP	ENSMMUP00000046341	ENSMMUP00000001617	Actinin alpha 2.	Nebulin related anchoring protein.	0.550
ACTN2	OBSL1	ENSMMUP00000046341	ENSMMUP00000059846	Actinin alpha 2.	Obscurin like 1.	0.455
ACTN2	PDLIM5	ENSMMUP00000046341	ENSMMUP00000029290	Actinin alpha 2.	PDZ and LIM domain 5.	0.475
ACTN2	TTN	ENSMMUP00000046341	ENSMMUP00000011868	Actinin alpha 2.	Titin.	0.967
ALPK3	OBSL1	ENSMMUP00000013679	ENSMMUP00000059846	Uncharacterized protein.	Obscurin like 1.	0.552
ATG5	MTOR	ENSMMUP00000025856	ENSMMUP00000073444	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.564
BMP10	BMPR1A	ENSMMUP00000019731	ENSMMUP00000079770	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.593
BMPR1A	BMP10	ENSMMUP00000079770	ENSMMUP00000019731	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10.	0.593
BVES	MYO18B	ENSMMUP00000019002	ENSMMUP00000004443	Blood vessel epicardial substance.	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.658
CAV3	OBSL1	ENSMMUP00000061270	ENSMMUP00000059846	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Obscurin like 1.	0.407
CAV3	SGCD	ENSMMUP00000061270	ENSMMUP00000006090	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sarcoglycan delta.	0.538
CSRP3	ACTN2	ENSMMUP00000067509	ENSMMUP00000046341	Cysteine and glycine rich protein 3.	Actinin alpha 2.	0.723
CSRP3	MYL2	ENSMMUP00000067509	ENSMMUP00000058528	Cysteine and glycine rich protein 3.	Myosin light chain 2.	0.773
CSRP3	NRAP	ENSMMUP00000067509	ENSMMUP00000001617	Cysteine and glycine rich protein 3.	Nebulin related anchoring protein.	0.563