(13 nodes) Metanephric tubule development network (Macaca mulatta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOX8	SRY-box transcription factor 8. (617 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4298 aa)
	CALB1	Calbindin 1. (261 aa)
	UMOD	Uromodulin. (641 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (969 aa)
	PAX2	Paired box 2. (418 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	HES5	Uncharacterized protein. (166 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALB1	PAX2	ENSMMUP00000008765	ENSMMUP00000012018	Calbindin 1.	Paired box 2.	0.462
HES5	SOX9	ENSMMUP00000062247	ENSMMUP00000073101	Uncharacterized protein.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.448
OSR1	PAX2	ENSMMUP00000058804	ENSMMUP00000012018	Odd-skipped related transcription factor 1.	Paired box 2.	0.431
PAX2	CALB1	ENSMMUP00000012018	ENSMMUP00000008765	Paired box 2.	Calbindin 1.	0.462
PAX2	OSR1	ENSMMUP00000012018	ENSMMUP00000058804	Paired box 2.	Odd-skipped related transcription factor 1.	0.431
PAX2	WNT4	ENSMMUP00000012018	ENSMMUP00000068014	Paired box 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.481
PKD1	PKD2	ENSMMUP00000003803	ENSMMUP00000011535	Polycystin 1, transient receptor potential channel interacting.	Polycystin 2, transient receptor potential cation channel.	0.984
PKD2	PKD1	ENSMMUP00000011535	ENSMMUP00000003803	Polycystin 2, transient receptor potential cation channel.	Polycystin 1, transient receptor potential channel interacting.	0.984
SOX8	WNT4	ENSMMUP00000069626	ENSMMUP00000068014	SRY-box transcription factor 8.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.502
SOX9	HES5	ENSMMUP00000073101	ENSMMUP00000062247	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Uncharacterized protein.	0.448
SOX9	WNT4	ENSMMUP00000073101	ENSMMUP00000068014	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.542
SOX9	WNT9B	ENSMMUP00000073101	ENSMMUP00000070542	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.404
WNT4	PAX2	ENSMMUP00000068014	ENSMMUP00000012018	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Paired box 2.	0.481
WNT4	SOX8	ENSMMUP00000068014	ENSMMUP00000069626	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	SRY-box transcription factor 8.	0.502
WNT4	SOX9	ENSMMUP00000068014	ENSMMUP00000073101	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.542
WNT4	WNT7B	ENSMMUP00000068014	ENSMMUP00000075667	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.552
WNT4	WNT9B	ENSMMUP00000068014	ENSMMUP00000070542	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.550
WNT7B	WNT4	ENSMMUP00000075667	ENSMMUP00000068014	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.552
WNT7B	WNT9B	ENSMMUP00000075667	ENSMMUP00000070542	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.479
WNT9B	SOX9	ENSMMUP00000070542	ENSMMUP00000073101	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.404