STRINGSTRING
GTF2E2 GTF2E2 FOXS1 FOXS1 FOXB1 FOXB1 ANAPC2 ANAPC2 PSMD12 PSMD12 ELF5 ELF5 FOXH1 FOXH1 F7HFM6_MACMU F7HFM6_MACMU FOXP1 FOXP1 FLI1 FLI1 ELK4 ELK4 POLR3F POLR3F LARP6 LARP6 FOXF2 FOXF2 ELL2 ELL2 FOXC1 FOXC1 HSF4 HSF4 EHF EHF UBR1 UBR1 DVL3 DVL3 IRF7 IRF7 TFDP1 TFDP1 SPDEF SPDEF HSF2 HSF2 FOXP2 FOXP2 FOXP3 FOXP3 CUL4B CUL4B ETS2 ETS2 PSMC3IP PSMC3IP FOXA2 FOXA2 RGS7 RGS7 KAT6A KAT6A TFDP2 TFDP2 FOXK1 FOXK1 PSMD13 PSMD13 E2F2 E2F2 SHPRH SHPRH REC8 REC8 GTF2F2 GTF2F2 H1-8 H1-8 ETV5 ETV5 CDT1 CDT1 FOXI1 FOXI1 FOXI3 FOXI3 RGS9 RGS9 HSF1 HSF1 STN1 STN1 HELQ HELQ SPI1 SPI1 ARID2 ARID2 PREX2 PREX2 RFX6 RFX6 TFDP3 TFDP3 ELK3 ELK3 RAD21L1 RAD21L1 RPA2 RPA2 IRF5 IRF5 FOXD2 FOXD2 ETV2 ETV2 RFX1 RFX1 CUL4A CUL4A FOXM1 FOXM1 ELK1 ELK1 BLM BLM FOXN3 FOXN3 FOXP4 FOXP4 F6TJP6_MACMU F6TJP6_MACMU FARSA FARSA FOXN4 FOXN4 PSMD3 PSMD3 ETS1 ETS1 GPR155 GPR155 SNF8 SNF8 LARP1B LARP1B FOXG1 FOXG1 FOXB2 FOXB2 FOXN1 FOXN1 H1-3 H1-3 IRF6 IRF6 ASCC3 ASCC3 COPS4 COPS4 FOXD3 FOXD3 ZBP1 ZBP1 WRN WRN IRF3 IRF3 E2F7 E2F7 E2F6 E2F6 SNRNP200 SNRNP200 E2F1 E2F1 H1-4 H1-4 EIF3E EIF3E E2F4 E2F4 RGS6 RGS6 RGS11 RGS11 FOXO3 FOXO3 RFX7 RFX7 LARP1 LARP1 RAPGEF5 RAPGEF5 CUL2 CUL2 VPS36 VPS36 FOXO1 FOXO1 CUL3 CUL3 FOXD4L1 FOXD4L1 RFX3 RFX3 FOXE1 FOXE1 PSMD6 PSMD6 LARP4 LARP4 HFM1 HFM1 DEPDC1 DEPDC1 FOXO4 FOXO4 LOC114672301 LOC114672301 FOXO6 FOXO6 FOXK2 FOXK2 LARP4B LARP4B ETV4 ETV4 ERF ERF GPS1 GPS1 ERG ERG HSF5 HSF5 E2F3 E2F3 IRF1 IRF1 DVL1 DVL1 YWHAH YWHAH LOC106995433 LOC106995433 LOC100270696 LOC100270696 ETV3 ETV3 ELF4 ELF4 COPS2 COPS2 COPS3 COPS3 EIF3K EIF3K RAPGEF4 RAPGEF4 FOXD1 FOXD1 ELL ELL RFX2 RFX2 DEPTOR DEPTOR ETV1 ETV1 H1-10 H1-10 E2F5 E2F5 RAPGEF3 RAPGEF3 ETV7 ETV7 PLEK2 PLEK2 DEPDC1B DEPDC1B LOC698693 LOC698693 DVL2 DVL2 ENSMMUP00000061681 ENSMMUP00000061681 VPS25 VPS25 FOXQ1 FOXQ1 IRF4 IRF4 PLEK PLEK RFX4 RFX4 LOC699342 LOC699342 FOXI2 FOXI2 SPIC SPIC RPS19 RPS19 RIOK2 RIOK2 FOXF1 FOXF1 FOXJ3 FOXJ3 DDRGK1 DDRGK1 CDC6 CDC6 H1-2 H1-2 ASMTL ASMTL CUL1 CUL1 ADAR ADAR HSFX3 HSFX3 IRF9 IRF9 H1-1 H1-1 LOC106995141 LOC106995141 IRF8 IRF8 H1-5 H1-5 FEV FEV ELF3 ELF3 ELF2 ELF2 HP1BP3 HP1BP3 LARP7 LARP7 PIKFYVE PIKFYVE FOXE3 FOXE3 FOXA1 FOXA1 LOC705696 LOC705696 FOXJ1 FOXJ1 RFX5 RFX5 FOXR1 FOXR1 FOXR2 FOXR2 PSMD11 PSMD11 FOXJ2 FOXJ2 METAP2 METAP2 FOXC2 FOXC2 ETV3L ETV3L EIF3M EIF3M IRF2 IRF2 GABPA GABPA RAD21 RAD21 UBR2 UBR2 LOC702793 LOC702793 E2F8 E2F8 FOXL2 FOXL2 ELF1 ELF1 ETV6 ETV6 LOC719262 LOC719262 DEPDC7 DEPDC7 HIST1H1T HIST1H1T KAT6B KAT6B PREX1 PREX1 FOXA3 FOXA3 ASMT ASMT FOXN2 FOXN2 ERFL ERFL
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (320 aa)
FOXS1Forkhead box S1. (330 aa)
FOXB1Forkhead box B1. (325 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (822 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (476 aa)
ELF5Uncharacterized protein. (265 aa)
FOXH1Forkhead box H1. (352 aa)
F7HFM6_MACMUHSF_DOMAIN domain-containing protein. (475 aa)
FOXP1Fork-head domain-containing protein. (695 aa)
FLI1Fli-1 proto-oncogene, ETS transcription factor. (475 aa)
ELK4ETS domain-containing protein Elk-4 isoform a. (431 aa)
POLR3FDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (314 aa)
LARP6La ribonucleoprotein domain family member 6. (491 aa)
FOXF2Forkhead box F2. (446 aa)
ELL2Elongation factor for RNA polymerase II 2. (641 aa)
FOXC1Forkhead box C1. (551 aa)
HSF4Heat shock transcription factor 4. (475 aa)
EHFETS homologous factor. (322 aa)
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1749 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (716 aa)
IRF7Interferon regulatory factor 7. (504 aa)
TFDP1Transcription factor. (410 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
HSF2Heat shock factor protein 2 isoform a. (536 aa)
FOXP2Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). (739 aa)
FOXP3Forkhead box P3. (539 aa)
CUL4BCullin 4B; Belongs to the cullin family. (933 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
PSMC3IPPSMC3 interacting protein. (234 aa)
FOXA2Forkhead box A2. (457 aa)
RGS7Regulator of G protein signaling 7. (487 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa)
TFDP2Uncharacterized protein. (490 aa)
FOXK1Forkhead box K1. (737 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (378 aa)
E2F2E2F transcription factor 2. (437 aa)
SHPRHE3 ubiquitin-protein ligase SHPRH isoform a. (1683 aa)
REC8REC8 meiotic recombination protein. (565 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
H1-8H1 histone family member O oocyte specific. (334 aa)
ETV5ETS translocation variant 5. (510 aa)
CDT1Chromatin licensing and DNA replication factor 1. (551 aa)
FOXI1Forkhead box I1. (378 aa)
FOXI3Forkhead box I3. (420 aa)
RGS9Regulator of G protein signaling 9. (658 aa)
HSF1Heat shock transcription factor 1. (507 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
HELQHelicase, POLQ like. (1101 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1607 aa)
RFX6Regulatory factor X6. (928 aa)
TFDP3Transcription factor. (406 aa)
ELK3ETS domain-containing protein Elk-3. (407 aa)
RAD21L1RAD21 cohesin complex component like 1. (559 aa)
RPA2Uncharacterized protein. (270 aa)
IRF5Interferon regulatory factor 5. (631 aa)
FOXD2Forkhead box D2. (495 aa)
ETV2ETS variant 2. (342 aa)
RFX1Regulatory factor X1. (1089 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
FOXM1Forkhead box protein M1 isoform 2. (770 aa)
ELK1ETS domain-containing protein Elk-1. (428 aa)
BLMBLM RecQ like helicase. (1416 aa)
FOXN3Forkhead box N3. (519 aa)
FOXP4Fork-head domain-containing protein. (680 aa)
F6TJP6_MACMUUncharacterized protein. (77 aa)
FARSAAA_TRNA_LIGASE_II domain-containing protein. (693 aa)
FOXN4Forkhead box N4. (517 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
ETS1ETS proto-oncogene 1, transcription factor. (548 aa)
GPR155G protein-coupled receptor 155. (872 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
LARP1BLa ribonucleoprotein domain family member 1B. (913 aa)
FOXG1Forkhead box G1. (489 aa)
FOXB2Forkhead box B2. (431 aa)
FOXN1Forkhead box N1. (648 aa)
H1-3Histone H1.3. (221 aa)
IRF6Interferon regulatory factor 6 isoform 1. (467 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3 isoform a. (2202 aa)
COPS4COP9 signalosome subunit 4. (420 aa)
FOXD3Fork-head domain-containing protein. (478 aa)
ZBP1Z-DNA binding protein 1. (420 aa)
WRNWRN RecQ like helicase. (1426 aa)
IRF3Interferon regulatory factor 3. (450 aa)
E2F7E2F transcription factor 7. (910 aa)
E2F6E2F transcription factor 6. (286 aa)
SNRNP200U5 small nuclear ribonucleoprotein 200 kDa helicase. (2136 aa)
E2F1E2F transcription factor 1. (437 aa)
H1-4Histone cluster 1 H1 family member e. (219 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (466 aa)
E2F4Transcription factor E2F4. (416 aa)
RGS6Uncharacterized protein. (491 aa)
RGS11Regulator of G protein signaling 11. (540 aa)
FOXO3Forkhead box O3. (672 aa)
RFX7Regulatory factor X7. (1459 aa)
LARP1La ribonucleoprotein domain family member 1. (1065 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (883 aa)
CUL2CULLIN_2 domain-containing protein; Belongs to the cullin family. (766 aa)
VPS36Vacuolar protein-sorting-associated protein 36. (386 aa)
FOXO1Forkhead box O1. (655 aa)
CUL3Cullin-3; Belongs to the cullin family. (768 aa)
FOXD4L1Forkhead box D4 like 1. (409 aa)
RFX3Regulatory factor X3. (760 aa)
FOXE1Forkhead box E1. (372 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
LARP4La ribonucleoprotein domain family member 4. (724 aa)
HFM1Helicase for meiosis 1. (1434 aa)
DEPDC1DEP domain containing 1. (811 aa)
FOXO4Fork head domain transcription factor AFX1. (505 aa)
LOC114672301ETS domain-containing protein. (488 aa)
FOXO6Forkhead box O6. (560 aa)
FOXK2Forkhead box K2. (658 aa)
LARP4BLa ribonucleoprotein domain family member 4B. (1846 aa)
ETV4ETS variant 4. (684 aa)
ERFETS domain-containing protein. (559 aa)
GPS1G protein pathway suppressor 1. (555 aa)
ERGETS transcription factor ERG. (486 aa)
HSF5Heat shock transcription factor 5. (598 aa)
E2F3E2F transcription factor 3. (465 aa)
IRF1Interferon regulatory factor. (325 aa)
DVL1Dishevelled segment polarity protein 1. (695 aa)
YWHAHDEP domain-containing protein. (1603 aa)
LOC106995433HSF_DOMAIN domain-containing protein. (401 aa)
LOC100270696HSF_DOMAIN domain-containing protein. (401 aa)
ETV3ETS translocation variant 3 isoform 1. (511 aa)
ELF4E74 like ETS transcription factor 4. (662 aa)
COPS2COP9 signalosome complex subunit 2 isoform 1. (443 aa)
COPS3COP9 signalosome complex subunit 3 isoform 1. (423 aa)
EIF3KEukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (330 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1047 aa)
FOXD1Forkhead box D1. (468 aa)
ELLElongation factor for RNA polymerase II. (621 aa)
RFX2Regulatory factor X2. (737 aa)
DEPTORDEP domain containing MTOR interacting protein. (409 aa)
ETV1ETS domain-containing protein. (491 aa)
H1-10Histone H1x. (213 aa)
E2F5E2F transcription factor 5. (346 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
ETV7ETS variant 7. (528 aa)
PLEK2Pleckstrin 2. (353 aa)
DEPDC1BDEP domain-containing protein 1B isoform 1. (529 aa)
LOC698693Histone H1.0. (194 aa)
DVL2Dishevelled segment polarity protein 2. (767 aa)
ENSMMUP00000061681Transcription factor. (409 aa)
VPS25Vacuolar protein sorting 25 homolog. (236 aa)
FOXQ1Forkhead box Q1. (403 aa)
IRF4Interferon regulatory factor 4 isoform 1. (451 aa)
PLEKPleckstrin. (350 aa)
RFX4RFX-type winged-helix domain-containing protein. (793 aa)
LOC699342PCI domain-containing protein. (395 aa)
FOXI2Forkhead box I2. (318 aa)
SPICETS domain-containing protein. (248 aa)
RPS19Uncharacterized protein. (355 aa)
RIOK2Serine/threonine-protein kinase RIO2 isoform 1. (551 aa)
FOXF1Forkhead box F1. (432 aa)
FOXJ3Forkhead box protein J3 isoform 1. (622 aa)
DDRGK1DDRGK domain-containing protein 1. (314 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (632 aa)
H1-2Histone cluster 1 H1 family member c. (195 aa)
ASMTLDimerisation2 domain-containing protein. (480 aa)
CUL1Cullin 1; Belongs to the cullin family. (809 aa)
ADARAdenosine deaminase RNA specific. (1268 aa)
HSFX3HSF_DOMAIN domain-containing protein. (334 aa)
IRF9Interferon regulatory factor 9. (455 aa)
H1-1Histone H1.1. (215 aa)
LOC106995141Uncharacterized protein. (621 aa)
IRF8IRF tryptophan pentad repeat domain-containing protein. (436 aa)
H1-5Histone H1a. (226 aa)
FEVFEV transcription factor, ETS family member. (238 aa)
ELF3E74 like ETS transcription factor 3. (371 aa)
ELF2ETS-related transcription factor Elf-2 isoform 1. (593 aa)
HP1BP3Heterochromatin protein 1-binding protein 3. (553 aa)
LARP7La ribonucleoprotein domain family member 7. (581 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2110 aa)
FOXE3Forkhead box E3. (318 aa)
FOXA1Fork-head domain-containing protein. (470 aa)
LOC705696Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (913 aa)
FOXJ1Forkhead box J1. (421 aa)
RFX5DNA-binding protein RFX5. (620 aa)
FOXR1Forkhead box R1. (292 aa)
FOXR2Forkhead box R2. (311 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (454 aa)
FOXJ2Forkhead box J2. (586 aa)
METAP2Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (478 aa)
FOXC2Forkhead box C2. (471 aa)
ETV3LETS variant 3 like. (360 aa)
EIF3MEukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (374 aa)
IRF2Interferon regulatory factor 2. (376 aa)
GABPAGA-binding protein alpha chain. (454 aa)
RAD21Double-strand-break repair protein rad21 homolog. (631 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
LOC702793Fork-head domain-containing protein. (233 aa)
E2F8E2F transcription factor 8. (867 aa)
FOXL2Forkhead box L2. (376 aa)
ELF1ETS-related transcription factor Elf-1 isoform a. (619 aa)
ETV6Uncharacterized protein. (457 aa)
LOC719262Transcription factor Spi-B. (262 aa)
DEPDC7DEP domain containing 7. (513 aa)
HIST1H1THistone H1t; Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration. (208 aa)
KAT6BHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2076 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1661 aa)
FOXA3Forkhead box A3. (350 aa)
ASMTAcetylserotonin O-methyltransferase; Catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. (345 aa)
FOXN2Forkhead box protein N2. (431 aa)
ERFLETS domain-containing protein. (581 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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