STRINGSTRING
APC APC ECD ECD SMARCC2 SMARCC2 CDK2 CDK2 FBXO31 FBXO31 DLG1 DLG1 PLCB1 PLCB1 STIL STIL SMARCD1 SMARCD1 CDKN2A CDKN2A TFDP1 TFDP1 LSM11 LSM11 BID BID GJC2 GJC2 DDR2 DDR2 KCNA5 KCNA5 LOC105466147 LOC105466147 ZC3H12D ZC3H12D ATM ATM ENSMNEP00000001266 ENSMNEP00000001266 CDKN1A CDKN1A SMARCE1 SMARCE1 CTDSP1 CTDSP1 CDC6 CDC6 RPTOR RPTOR LSM10 LSM10 CDK10 CDK10 ARID1B ARID1B GIGYF2 GIGYF2 EGFR EGFR E2F7 E2F7 PHF10 PHF10 E2F1 E2F1 RFWD3 RFWD3 CDK7 CDK7 ENSMNEP00000006880 ENSMNEP00000006880 PTEN PTEN FBXO7 FBXO7 RRM2 RRM2 MUC1 MUC1 ANXA1 ANXA1 PIDD1 PIDD1 PKD2 PKD2 ANKRD17 ANKRD17 DACT1 DACT1 RPL26L1 RPL26L1 RB1 RB1 SASS6 SASS6 TCF3 TCF3 CENPJ CENPJ STOX1 STOX1 DPF3 DPF3 KANK2 KANK2 CRADD CRADD PSME2 PSME2 ADAM17 ADAM17 ENSMNEP00000013845 ENSMNEP00000013845 SMARCA4 SMARCA4 ENSMNEP00000014624 ENSMNEP00000014624 CCND2 CCND2 MNAT1 MNAT1 CDKN1B CDKN1B CDKN2C CDKN2C ENSMNEP00000015304 ENSMNEP00000015304 DDX3X DDX3X ENSMNEP00000015849 ENSMNEP00000015849 CTDSPL CTDSPL KLF4 KLF4 WAC WAC ENSMNEP00000017328 ENSMNEP00000017328 CACNB4 CACNB4 ZNF655 ZNF655 DPF2 DPF2 PLK5 PLK5 PBRM1 PBRM1 SMARCD3 SMARCD3 ARID2 ARID2 CDKN2D CDKN2D APPL1 APPL1 RPS27L RPS27L RBL2 RBL2 SMARCB1 SMARCB1 FGF10 FGF10 SMARCD2 SMARCD2 RBM38 RBM38 NACC2 NACC2 INO80 INO80 PPP2R5C PPP2R5C RRM1 RRM1 BCL2 BCL2 CUL4B CUL4B ENSMNEP00000024033 ENSMNEP00000024033 ACTL6B ACTL6B KIF14 KIF14 GFI1B GFI1B CTDSP2 CTDSP2 AKT1 AKT1 WEE1 WEE1 DCUN1D3 DCUN1D3 AIF1 AIF1 GPNMB GPNMB ENSMNEP00000026876 ENSMNEP00000026876 HYAL1 HYAL1 RGCC RGCC RBL1 RBL1 ACVR1 ACVR1 ENSMNEP00000027688 ENSMNEP00000027688 CDC73 CDC73 EIF4G1 EIF4G1 CCND3 CCND3 JADE1 JADE1 PTPN6 PTPN6 MEPCE MEPCE RPL26 RPL26 SDE2 SDE2 PRMT2 PRMT2 MYO16 MYO16 ADAMTS1 ADAMTS1 PLK3 PLK3 CPSF3 CPSF3 ARID1A ARID1A ENSMNEP00000032887 ENSMNEP00000032887 APPL2 APPL2 UBE2E2 UBE2E2 BCL7A BCL7A GML GML FHL1 FHL1 BTN2A2 BTN2A2 CCND1 CCND1 BCL7B BCL7B PRKDC PRKDC MTBP MTBP TERT TERT CDKN2B CDKN2B KMT2E KMT2E ENSMNEP00000036565 ENSMNEP00000036565 AMBRA1 AMBRA1 ENSMNEP00000036627 ENSMNEP00000036627 PRAP1 PRAP1 BRD7 BRD7 CCNH CCNH ENSMNEP00000037627 ENSMNEP00000037627 INHBA INHBA BCL7C BCL7C SMARCA2 SMARCA2 PLRG1 PLRG1 ENSMNEP00000038452 ENSMNEP00000038452 EZH2 EZH2 RDX RDX TM4SF5 TM4SF5 CDK2AP2 CDK2AP2 DPF1 DPF1 CASP2 CASP2 DGKZ DGKZ PML PML CHEK2 CHEK2 TRIAP1 TRIAP1 PKD1 PKD1 PPP2CA PPP2CA SMARCC1 SMARCC1 PDPN PDPN CUL4A CUL4A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APCAPC regulator of WNT signaling pathway. (2864 aa)
ECDEcdysoneless cell cycle regulator. (646 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1268 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
FBXO31F-box protein 31. (543 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (947 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
STILSTIL centriolar assembly protein. (1294 aa)
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (160 aa)
TFDP1Transcription factor. (410 aa)
LSM11LSM11, U7 small nuclear RNA associated. (360 aa)
BIDBH3 interacting domain death agonist. (266 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (438 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (873 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
LOC105466147Uncharacterized protein. (145 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (526 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa)
ENSMNEP00000001266Uncharacterized protein. (234 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
CTDSP1CTD small phosphatase 1. (261 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (544 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
CDK10Cyclin dependent kinase 10; Belongs to the protein kinase superfamily. (361 aa)
ARID1BAT-rich interaction domain 1B. (1539 aa)
GIGYF2GRB10 interacting GYF protein 2. (1328 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
E2F7E2F transcription factor 7. (867 aa)
PHF10PHD finger protein 10. (498 aa)
E2F1E2F transcription factor 1. (437 aa)
RFWD3Ring finger and WD repeat domain 3. (774 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
ENSMNEP00000006880LIM zinc-binding domain-containing protein. (189 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FBXO7F-box protein 7. (522 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (439 aa)
MUC1Mucin 1, cell surface associated. (449 aa)
ANXA1Annexin. (346 aa)
PIDD1P53-induced death domain protein 1. (936 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (969 aa)
ANKRD17Ankyrin repeat domain 17. (2603 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (837 aa)
RPL26L1Ribosomal protein L26 like 1. (145 aa)
RB1RB transcriptional corepressor 1. (928 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
TCF3Transcription factor 3. (680 aa)
CENPJCentromere protein J. (1340 aa)
STOX1Storkhead box 1. (887 aa)
DPF3Double PHD fingers 3. (412 aa)
KANK2KN motif and ankyrin repeat domains 2. (851 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
PSME2Proteasome activator subunit 2. (254 aa)
ADAM17ADAM metallopeptidase domain 17. (803 aa)
ENSMNEP00000013845Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (436 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1677 aa)
ENSMNEP00000014624Uncharacterized protein. (445 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (316 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
ENSMNEP00000015304Uncharacterized protein. (358 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
ENSMNEP00000015849Transcription factor. (392 aa)
CTDSPLCTD small phosphatase like. (281 aa)
KLF4Kruppel like factor 4. (479 aa)
WACWW domain containing adaptor with coiled-coil. (647 aa)
ENSMNEP00000017328Uncharacterized protein. (168 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
ZNF655Zinc finger protein 655. (597 aa)
DPF2Double PHD fingers 2. (405 aa)
PLK5Polo like kinase 5. (299 aa)
PBRM1Polybromo 1. (1709 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (508 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (715 aa)
RPS27L40S ribosomal protein S27. (84 aa)
RBL2RB transcriptional corepressor like 2. (1141 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (531 aa)
RBM38RNA binding motif protein 38. (237 aa)
NACC2NACC family member 2. (586 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (533 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CUL4BCullin 4B; Belongs to the cullin family. (913 aa)
ENSMNEP00000024033Uncharacterized protein. (265 aa)
ACTL6BActin like 6B; Belongs to the actin family. (447 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1647 aa)
GFI1BGrowth factor independent 1B transcriptional repressor. (330 aa)
CTDSP2CTD small phosphatase 2. (277 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
WEE1Wee1-like protein kinase. (646 aa)
DCUN1D3DCN1-like protein. (304 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
GPNMBGlycoprotein nmb. (561 aa)
ENSMNEP00000026876KOW domain-containing protein. (138 aa)
HYAL1Hyaluronidase. (435 aa)
RGCCRegulator of cell cycle. (137 aa)
RBL1RB transcriptional corepressor like 1. (1137 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ENSMNEP00000027688KOW domain-containing protein. (145 aa)
CDC73Cell division cycle 73. (531 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1604 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (242 aa)
JADE1Jade family PHD finger 1. (858 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
MEPCEMethylphosphate capping enzyme. (689 aa)
RPL26KOW domain-containing protein. (146 aa)
SDE2SDE2 telomere maintenance homolog. (451 aa)
PRMT2Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (433 aa)
MYO16Myosin XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1876 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
PLK3Serine/threonine-protein kinase PLK. (608 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (625 aa)
ARID1AAT-rich interaction domain 1A. (2290 aa)
ENSMNEP00000032887Protein kinase domain-containing protein. (324 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (786 aa)
UBE2E2Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (231 aa)
GMLGlycosylphosphatidylinositol anchored molecule like. (158 aa)
FHL1Four and a half LIM domains 1. (339 aa)
BTN2A2Uncharacterized protein. (519 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
BCL7BBAF chromatin remodeling complex subunit BCL7B. (185 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4054 aa)
MTBPMDM2 binding protein. (904 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
KMT2ELysine methyltransferase 2E. (1859 aa)
ENSMNEP00000036565HMG box domain-containing protein. (177 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
ENSMNEP00000036627DCN1-like protein. (276 aa)
PRAP1Uncharacterized protein. (153 aa)
BRD7Bromodomain containing 7. (598 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
ENSMNEP00000037627Uncharacterized protein. (339 aa)
INHBAInhibin subunit beta A. (426 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (242 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1583 aa)
PLRG1Pleiotropic regulator 1. (514 aa)
ENSMNEP00000038452Uncharacterized protein. (396 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
RDXRadixin. (604 aa)
TM4SF5Transmembrane 4 L six family member 5. (201 aa)
CDK2AP2Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (126 aa)
DPF1Double PHD fingers 1. (414 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
DGKZDiacylglycerol kinase. (1172 aa)
PMLPromyelocytic leukemia. (882 aa)
CHEK2Checkpoint kinase 2. (588 aa)
TRIAP1TP53 regulated inhibitor of apoptosis 1. (76 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1105 aa)
PDPNPodoplanin. (162 aa)
CUL4ACullin 4A; Belongs to the cullin family. (745 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (28%) [HD]