STRINGSTRING
LEP LEP TGFB1 TGFB1 CD4 CD4 TGFB2 TGFB2 PIK3CA PIK3CA LOX LOX IL10 IL10 CXCL8 CXCL8 SMAD4 SMAD4 CXCL6 CXCL6 PDGFRB PDGFRB MZF1 MZF1 EGF EGF STK11 STK11 ALDH3B2 ALDH3B2 CALR3 CALR3 ATM ATM PGR PGR MAP3K1 MAP3K1 CD86 CD86 FOXP2 FOXP2 PALB2 PALB2 CD19 CD19 HSP90AB1 HSP90AB1 BMP6 BMP6 CSK CSK PEAK1 PEAK1 BMP7 BMP7 VIM VIM ESR1 ESR1 INHBA INHBA CXCR4 CXCR4 CHEK2 CHEK2 NOTCH1 NOTCH1 TGFB3 TGFB3 TIMP2 TIMP2 SOX2 SOX2 BMP4 BMP4 CD40 CD40 MMP9 MMP9 WIF1 WIF1 MMP12 MMP12 FGF2 FGF2 NES NES CD38 CD38 RECK RECK MAP2K4 MAP2K4 GATA3 GATA3 PTEN PTEN WNK1 WNK1 BRCA2 BRCA2 IL6 IL6 VCAM1 VCAM1 CD44 CD44 ALDH3B1 ALDH3B1 BRCA1 BRCA1 MMP13 MMP13 ALDH3A1 ALDH3A1 SRC SRC TLR4 TLR4 EPCAM EPCAM TP53 TP53 CD40LG CD40LG STAT3 STAT3 IGF1 IGF1 CCL2 CCL2 ALDH3A2 ALDH3A2 DKK1 DKK1 CD69 CD69 CXCR2 CXCR2 LRP5 LRP5 ABCG2 ABCG2 CALR CALR IFNG IFNG NANOG NANOG HGF HGF TLR3 TLR3 MCL1 MCL1 SLC9A1 SLC9A1 IL2 IL2 BMP1 BMP1 CCR5 CCR5 CCR2 CCR2 EPO EPO IL6R IL6R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CD4CD4 molecule. (458 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOXLysyl oxidase. (417 aa)
IL10Interleukin 10. (178 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CXCL6C-X-C motif chemokine. (114 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
MZF1Myeloid zinc finger 1. (775 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
ALDH3B2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
CALR3Calreticulin. (384 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. (932 aa)
MAP3K1Uncharacterized protein. (1508 aa)
CD86Ig-like domain-containing protein. (329 aa)
FOXP2Fork-head domain-containing protein. (678 aa)
PALB2Partner and localizer of BRCA2. (1184 aa)
CD19CD19 molecule. (558 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
BMP6Bone morphogenetic protein 6. (515 aa)
CSKTyrosine-protein kinase. (450 aa)
PEAK1Pseudopodium enriched atypical kinase 1. (1746 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
INHBAInhibin subunit beta A. (426 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (355 aa)
CHEK2Checkpoint kinase 2. (589 aa)
NOTCH1Notch receptor 1. (2541 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TIMP2TIMP metallopeptidase inhibitor 2. (220 aa)
SOX2SRY-box transcription factor 2. (319 aa)
BMP4Bone morphogenetic protein 4, isoform 3 (Predicted). (408 aa)
CD40Uncharacterized protein. (262 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
WIF1WNT inhibitory factor 1. (379 aa)
MMP12Matrix metallopeptidase 12. (426 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
NESNestin; Belongs to the intermediate filament family. (1619 aa)
CD38CD38 molecule. (301 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (466 aa)
GATA3GATA binding protein 3. (444 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
WNK1WNK lysine deficient protein kinase 1. (2835 aa)
BRCA2BRCA2 DNA repair associated. (3430 aa)
IL6Uncharacterized protein. (214 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
ALDH3B1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (533 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1857 aa)
MMP13Matrix metallopeptidase 13. (501 aa)
ALDH3A1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (480 aa)
SRCTyrosine-protein kinase. (644 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (836 aa)
EPCAMEpithelial cell adhesion molecule. (331 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IGF1Insulin like growth factor 1. (208 aa)
CCL2C-C motif chemokine. (99 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (552 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
CD69CD69 molecule. (199 aa)
CXCR2C-X-C motif chemokine receptor 2. (328 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
ABCG2ABC transporter domain-containing protein. (655 aa)
CALRCalreticulin. (417 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (165 aa)
NANOGHomeobox domain-containing protein. (305 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
BMP1Metalloendopeptidase. (986 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
IL6RInterleukin 6 receptor. (468 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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