(57 nodes) Antibacterial humoral response network (Gorilla gorilla)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TAC1	Tachykinin precursor 1. (129 aa)
	ENSGGOP00000049719	Uncharacterized protein. (51 aa)
	ENSGGOP00000051553	annotation not available (126 aa)
	ENSGGOP00000050208	annotation not available (126 aa)
	H2BC12	Histone H2B; Belongs to the histone H2B family. (126 aa)
	G3QER9_GORGO	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (246 aa)
	SPON2	Spondin 2. (331 aa)
	FAU	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (136 aa)
	WFDC5	WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor. (224 aa)
	DEFA1B	DEFENSIN domain-containing protein. (94 aa)
	WFDC3	WAP four-disulfide core domain 3. (234 aa)
	PLA2G1B	Phospholipase A(2). (148 aa)
	WFDC9	WAP four-disulfide core domain 9. (89 aa)
	G3QX42_GORGO	Bactericidal permeability increasing protein. (487 aa)
	RPL39	Uncharacterized protein. (51 aa)
	LTF	Lactotransferrin; Belongs to the transferrin family. (711 aa)
	DCD	Dermcidin. (120 aa)
	SFTPD	Surfactant protein D. (375 aa)
	LGALS4	Galectin. (323 aa)
	TF	Transferrin; Belongs to the transferrin family. (698 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	DEFA4	Defensin alpha 4. (97 aa)
	DEFA6	Defensin alpha 6. (100 aa)
	ADM	Adrenomedullin. (185 aa)
	DEFB1	Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (68 aa)
	CAMP	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa)
	WFDC10A	WAP four-disulfide core domain 10A. (79 aa)
	G3RAL4_GORGO	Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (354 aa)
	G3RD46_GORGO	Cathepsin G; Belongs to the peptidase S1 family. (255 aa)
	FGB	Fibrinogen beta chain. (491 aa)
	CALCA	Calcitonin related polypeptide alpha. (141 aa)
	WFDC13	WAP four-disulfide core domain 13. (93 aa)
	DEFA5	Defensin alpha 5. (94 aa)
	SLPI	Secretory leukocyte peptidase inhibitor. (132 aa)
	PLA2G6	Phospholipase A2 group VI. (806 aa)
	RNASE3	Eosinophil cationic protein; Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity (By similarity). (160 aa)
	WFDC11	WAP four-disulfide core domain 11. (87 aa)
	JCHAIN	Joining chain of multimeric IgA and IgM. (159 aa)
	G3RXV4_GORGO	Uncharacterized protein. (345 aa)
	PI3	Peptidase inhibitor 3. (117 aa)
	FGA	Fibrinogen alpha chain. (866 aa)
	G3SDT0_GORGO	Histone H2B; Belongs to the histone H2B family. (126 aa)
	WFDC12	WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor (By similarity). (110 aa)
	BPIFA1	BPI fold containing family A member 1. (256 aa)
	RNASE6	Ribonuclease K6; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. (150 aa)
	G3SK93_GORGO	Histone H2B; Belongs to the histone H2B family. (126 aa)
	ENSGGOP00000031506	DEFENSIN domain-containing protein. (93 aa)
	ANG	Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity). (147 aa)
	ENSGGOP00000036130	Uncharacterized protein. (51 aa)
	ENSGGOP00000036847	Uncharacterized protein. (51 aa)
	ENSGGOP00000037086	Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (72 aa)
	ENSGGOP00000037298	Uncharacterized protein. (51 aa)
	G3RXM3_GORGO	Histone H2B; Belongs to the histone H2B family. (126 aa)
	RNASE7	Ribonuclease A family member 7; Belongs to the pancreatic ribonuclease family. (156 aa)
	ENSGGOP00000041630	Uncharacterized protein. (75 aa)
	ENSGGOP00000045214	Fib_alpha domain-containing protein. (288 aa)
	ENSGGOP00000046102	Small proline rich protein 2A. (72 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADM	CALCA	ENSGGOP00000010974	ENSGGOP00000013802	Adrenomedullin.	Calcitonin related polypeptide alpha.	0.967
ANG	RNASE3	ENSGGOP00000035667	ENSGGOP00000017122	Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity).	Eosinophil cationic protein; Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity (By similarity).	0.742
ANG	RNASE6	ENSGGOP00000035667	ENSGGOP00000027666	Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity).	Ribonuclease K6; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity.	0.442
ANG	RNASE7	ENSGGOP00000035667	ENSGGOP00000039130	Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity).	Ribonuclease A family member 7; Belongs to the pancreatic ribonuclease family.	0.410
BPIFA1	G3QER9_GORGO	ENSGGOP00000027234	ENSGGOP00000000768	BPI fold containing family A member 1.	Elastase, neutrophil expressed; Belongs to the peptidase S1 family.	0.478
BPIFA1	G3QX42_GORGO	ENSGGOP00000027234	ENSGGOP00000007373	BPI fold containing family A member 1.	Bactericidal permeability increasing protein.	0.554
BPIFA1	LTF	ENSGGOP00000027234	ENSGGOP00000007900	BPI fold containing family A member 1.	Lactotransferrin; Belongs to the transferrin family.	0.546
CALCA	ADM	ENSGGOP00000013802	ENSGGOP00000010974	Calcitonin related polypeptide alpha.	Adrenomedullin.	0.967
CALCA	TAC1	ENSGGOP00000013802	ENSGGOP00000047089	Calcitonin related polypeptide alpha.	Tachykinin precursor 1.	0.666
CAMP	DCD	ENSGGOP00000012112	ENSGGOP00000008198	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family.	Dermcidin.	0.483
CAMP	DEFA4	ENSGGOP00000012112	ENSGGOP00000010619	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family.	Defensin alpha 4.	0.633
CAMP	DEFA5	ENSGGOP00000012112	ENSGGOP00000015706	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family.	Defensin alpha 5.	0.542
CAMP	DEFA6	ENSGGOP00000012112	ENSGGOP00000010623	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family.	Defensin alpha 6.	0.403
CAMP	DEFB1	ENSGGOP00000012112	ENSGGOP00000011433	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family.	Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.	0.672
CAMP	ENSGGOP00000031506	ENSGGOP00000012112	ENSGGOP00000031506	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family.	DEFENSIN domain-containing protein.	0.633
CAMP	ENSGGOP00000037086	ENSGGOP00000012112	ENSGGOP00000037086	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family.	Defensin_propep domain-containing protein; Belongs to the alpha-defensin family.	0.633
CAMP	G3QER9_GORGO	ENSGGOP00000012112	ENSGGOP00000000768	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family.	Elastase, neutrophil expressed; Belongs to the peptidase S1 family.	0.897
CAMP	G3QX42_GORGO	ENSGGOP00000012112	ENSGGOP00000007373	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family.	Bactericidal permeability increasing protein.	0.780
CAMP	G3RD46_GORGO	ENSGGOP00000012112	ENSGGOP00000013442	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family.	Cathepsin G; Belongs to the peptidase S1 family.	0.819
CAMP	LTF	ENSGGOP00000012112	ENSGGOP00000007900	Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family.	Lactotransferrin; Belongs to the transferrin family.	0.801