(12 nodes) (2019) Nonhuman primate species as models of human bacterial sepsis. network (Gorilla gorilla)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Predicted Interactions

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Your Input:
	TFPI	Tissue factor pathway inhibitor. (304 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	CCN2	Cellular communication network factor 2. (348 aa)
	TFPI2	Tissue factor pathway inhibitor. (235 aa)
	G3QPK5_GORGO	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	IL10	Interleukin 10. (178 aa)
	CCL2	C-C motif chemokine. (99 aa)
	SELL	L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (385 aa)
	IL6	Interleukin 6. (234 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	F3	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL2	CCN2	ENSGGOP00000015811	ENSGGOP00000051935	C-C motif chemokine.	Cellular communication network factor 2.	0.494
CCL2	F3	ENSGGOP00000015811	ENSGGOP00000039628	C-C motif chemokine.	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	0.479
CCL2	G3QPK5_GORGO	ENSGGOP00000015811	ENSGGOP00000004502	C-C motif chemokine.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.528
CCL2	IL10	ENSGGOP00000015811	ENSGGOP00000013944	C-C motif chemokine.	Interleukin 10.	0.839
CCL2	IL6	ENSGGOP00000015811	ENSGGOP00000018546	C-C motif chemokine.	Interleukin 6.	0.896
CCL2	SELL	ENSGGOP00000015811	ENSGGOP00000017297	C-C motif chemokine.	L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.	0.456
CCL2	TGFB1	ENSGGOP00000015811	ENSGGOP00000026415	C-C motif chemokine.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.664
CCL2	TLR4	ENSGGOP00000015811	ENSGGOP00000020706	C-C motif chemokine.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.546
CCN2	CCL2	ENSGGOP00000051935	ENSGGOP00000015811	Cellular communication network factor 2.	C-C motif chemokine.	0.494
CCN2	G3QPK5_GORGO	ENSGGOP00000051935	ENSGGOP00000004502	Cellular communication network factor 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.585
CCN2	IL6	ENSGGOP00000051935	ENSGGOP00000018546	Cellular communication network factor 2.	Interleukin 6.	0.508
CCN2	TGFB1	ENSGGOP00000051935	ENSGGOP00000026415	Cellular communication network factor 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.793
CCN2	TGFB3	ENSGGOP00000051935	ENSGGOP00000001462	Cellular communication network factor 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.650
F3	CCL2	ENSGGOP00000039628	ENSGGOP00000015811	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	C-C motif chemokine.	0.479
F3	IL10	ENSGGOP00000039628	ENSGGOP00000013944	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	Interleukin 10.	0.442
F3	IL6	ENSGGOP00000039628	ENSGGOP00000018546	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	Interleukin 6.	0.663
F3	TFPI	ENSGGOP00000039628	ENSGGOP00000048998	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	Tissue factor pathway inhibitor.	0.976
F3	TFPI2	ENSGGOP00000039628	ENSGGOP00000004420	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	Tissue factor pathway inhibitor.	0.799
F3	TLR4	ENSGGOP00000039628	ENSGGOP00000020706	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.454
G3QPK5_GORGO	CCL2	ENSGGOP00000004502	ENSGGOP00000015811	Transforming growth factor beta; Belongs to the TGF-beta family.	C-C motif chemokine.	0.528