(10 nodes) Biotin/lipoyl attachment network (Pan troglodytes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	ACACB	ACACB isoform 2. (2458 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2383 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
	DBT	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (507 aa)
	MCCC1	Methylcrotonoyl-CoA carboxylase 1 (Alpha). (725 aa)
	GCSH	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (173 aa)
	DLST	Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex). (453 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1179 aa)
	PCCA	Propionyl CoA carboxylase, alpha polypeptide. (728 aa)
	PDHX	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSPTRP00000074254	ENSPTRP00000079596	Acetyl-CoA carboxylase alpha.	ACACB isoform 2.	0.934
ACACA	DLAT	ENSPTRP00000074254	ENSPTRP00000007349	Acetyl-CoA carboxylase alpha.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.921
ACACA	MCCC1	ENSPTRP00000074254	ENSPTRP00000026948	Acetyl-CoA carboxylase alpha.	Methylcrotonoyl-CoA carboxylase 1 (Alpha).	0.619
ACACA	PC	ENSPTRP00000074254	ENSPTRP00000045149	Acetyl-CoA carboxylase alpha.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.627
ACACA	PCCA	ENSPTRP00000074254	ENSPTRP00000010202	Acetyl-CoA carboxylase alpha.	Propionyl CoA carboxylase, alpha polypeptide.	0.619
ACACB	ACACA	ENSPTRP00000079596	ENSPTRP00000074254	ACACB isoform 2.	Acetyl-CoA carboxylase alpha.	0.934
ACACB	DLAT	ENSPTRP00000079596	ENSPTRP00000007349	ACACB isoform 2.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.921
ACACB	MCCC1	ENSPTRP00000079596	ENSPTRP00000026948	ACACB isoform 2.	Methylcrotonoyl-CoA carboxylase 1 (Alpha).	0.609
ACACB	PC	ENSPTRP00000079596	ENSPTRP00000045149	ACACB isoform 2.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.564
ACACB	PCCA	ENSPTRP00000079596	ENSPTRP00000010202	ACACB isoform 2.	Propionyl CoA carboxylase, alpha polypeptide.	0.608
DBT	DLAT	ENSPTRP00000001722	ENSPTRP00000007349	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.657
DBT	DLST	ENSPTRP00000001722	ENSPTRP00000011110	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex).	0.774
DBT	GCSH	ENSPTRP00000001722	ENSPTRP00000014317	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.619
DBT	MCCC1	ENSPTRP00000001722	ENSPTRP00000026948	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Methylcrotonoyl-CoA carboxylase 1 (Alpha).	0.606
DBT	PCCA	ENSPTRP00000001722	ENSPTRP00000010202	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Propionyl CoA carboxylase, alpha polypeptide.	0.958
DBT	PDHX	ENSPTRP00000001722	ENSPTRP00000088121	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.652
DLAT	ACACA	ENSPTRP00000007349	ENSPTRP00000074254	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Acetyl-CoA carboxylase alpha.	0.921
DLAT	ACACB	ENSPTRP00000007349	ENSPTRP00000079596	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	ACACB isoform 2.	0.921
DLAT	DBT	ENSPTRP00000007349	ENSPTRP00000001722	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.657
DLAT	DLST	ENSPTRP00000007349	ENSPTRP00000011110	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex).	0.887