(13 nodes) ATP-grasp fold, subdomain 1 network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

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protein homology

Your Input:
	CAD	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2229 aa)
	SYN2	SYN2 isoform 1. (570 aa)
	SYN3	SYN3 isoform 1. (580 aa)
	RIMKLA	Ribosomal modification protein rimK like family member A. (391 aa)
	SUCLA2	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa)
	PCCA	Propionyl CoA carboxylase, alpha polypeptide. (728 aa)
	GART	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2383 aa)
	SYN1	SYN1 isoform 1. (705 aa)
	SUCLG2	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (440 aa)
	ACACB	ACACB isoform 2. (2458 aa)
	RIMKLB	Ribosomal modification protein rimK-like family member B. (386 aa)
	CPS1	Carbamoyl-phosphate synthase 1, mitochondrial. (1507 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSPTRP00000074254	ENSPTRP00000079596	Acetyl-CoA carboxylase alpha.	ACACB isoform 2.	0.934
ACACA	GART	ENSPTRP00000074254	ENSPTRP00000045223	Acetyl-CoA carboxylase alpha.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.893
ACACA	PCCA	ENSPTRP00000074254	ENSPTRP00000010202	Acetyl-CoA carboxylase alpha.	Propionyl CoA carboxylase, alpha polypeptide.	0.619
ACACA	SUCLA2	ENSPTRP00000074254	ENSPTRP00000009968	Acetyl-CoA carboxylase alpha.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.848
ACACA	SUCLG2	ENSPTRP00000074254	ENSPTRP00000079150	Acetyl-CoA carboxylase alpha.	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.848
ACACB	ACACA	ENSPTRP00000079596	ENSPTRP00000074254	ACACB isoform 2.	Acetyl-CoA carboxylase alpha.	0.934
ACACB	GART	ENSPTRP00000079596	ENSPTRP00000045223	ACACB isoform 2.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.893
ACACB	PCCA	ENSPTRP00000079596	ENSPTRP00000010202	ACACB isoform 2.	Propionyl CoA carboxylase, alpha polypeptide.	0.608
ACACB	SUCLA2	ENSPTRP00000079596	ENSPTRP00000009968	ACACB isoform 2.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.848
ACACB	SUCLG2	ENSPTRP00000079596	ENSPTRP00000079150	ACACB isoform 2.	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.848
CAD	CPS1	ENSPTRP00000086335	ENSPTRP00000087073	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	Carbamoyl-phosphate synthase 1, mitochondrial.	0.902
CAD	GART	ENSPTRP00000086335	ENSPTRP00000045223	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.792
CAD	PCCA	ENSPTRP00000086335	ENSPTRP00000010202	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	Propionyl CoA carboxylase, alpha polypeptide.	0.473
CPS1	CAD	ENSPTRP00000087073	ENSPTRP00000086335	Carbamoyl-phosphate synthase 1, mitochondrial.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.902
CPS1	GART	ENSPTRP00000087073	ENSPTRP00000045223	Carbamoyl-phosphate synthase 1, mitochondrial.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.792
CPS1	PCCA	ENSPTRP00000087073	ENSPTRP00000010202	Carbamoyl-phosphate synthase 1, mitochondrial.	Propionyl CoA carboxylase, alpha polypeptide.	0.473
GART	ACACA	ENSPTRP00000045223	ENSPTRP00000074254	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Acetyl-CoA carboxylase alpha.	0.893
GART	ACACB	ENSPTRP00000045223	ENSPTRP00000079596	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	ACACB isoform 2.	0.893
GART	CAD	ENSPTRP00000045223	ENSPTRP00000086335	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.792
GART	CPS1	ENSPTRP00000045223	ENSPTRP00000087073	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Carbamoyl-phosphate synthase 1, mitochondrial.	0.792