STRINGSTRING
ENSPTRP00000086173 ENSPTRP00000086173 ENSPTRP00000093891 ENSPTRP00000093891 RUNX1 RUNX1 ENSPTRP00000092628 ENSPTRP00000092628 H2AC20 H2AC20 LOC471875 LOC471875 H2BC6 H2BC6 ENSPTRP00000090987 ENSPTRP00000090987 E2F1-2 E2F1-2 LOC457262-10 LOC457262-10 H2BU1 H2BU1 ENSPTRP00000087746 ENSPTRP00000087746 LOC457262-9 LOC457262-9 CCND1 CCND1 LOC462509 LOC462509 H3F3B H3F3B H2BC14 H2BC14 TNRC6C TNRC6C LOC457262-8 LOC457262-8 CK820_G0031483 CK820_G0031483 ENSPTRP00000084305 ENSPTRP00000084305 LOC457262-7 LOC457262-7 TFDP1 TFDP1 ENSPTRP00000082196 ENSPTRP00000082196 TNRC6B TNRC6B ENSPTRP00000081714 ENSPTRP00000081714 MAMLD1-2 MAMLD1-2 AGO1 AGO1 MAML3 MAML3 RBPJ RBPJ LOC457262-6 LOC457262-6 LOC107966300 LOC107966300 ENSPTRP00000078054 ENSPTRP00000078054 LOC457262-5 LOC457262-5 ELF3 ELF3 H4C8 H4C8 LOC746430 LOC746430 NOTCH2 NOTCH2 CREBBP CREBBP LOC107971249-2 LOC107971249-2 LOC471883-2 LOC471883-2 LOC112209457-4 LOC112209457-4 ENSPTRP00000074115 ENSPTRP00000074115 TFDP2 TFDP2 H2BC5 H2BC5 LOC471883 LOC471883 H2BC9 H2BC9 LOC104001083 LOC104001083 LOC471880 LOC471880 ENSPTRP00000069899 ENSPTRP00000069899 H2AFV-2 H2AFV-2 LOC457262-4 LOC457262-4 LOC471876 LOC471876 LOC746468 LOC746468 E2F3 E2F3 PRKCI PRKCI ENSPTRP00000065877 ENSPTRP00000065877 ENSPTRP00000065421 ENSPTRP00000065421 MAMLD1 MAMLD1 LOC457262-3 LOC457262-3 LOC104001101 LOC104001101 SNW1 SNW1 LOC112209457-2 LOC112209457-2 LOC462508 LOC462508 LOC471907 LOC471907 LOC107971253 LOC107971253 H2AJ H2AJ NOTCH4 NOTCH4 MAML1 MAML1 H2BC21 H2BC21 HIST1H2AE HIST1H2AE H2BC13 H2BC13 H3C13 H3C13 TFDP3 TFDP3 TNRC6A TNRC6A AGO4 AGO4 LOC107971249 LOC107971249 NOTCH1 NOTCH1 AGO2 AGO2 H2AFV H2AFV H2AC14 H2AC14 H2BC11 H2BC11 H2AC6 H2AC6 LOC462501 LOC462501 LOC457262-2 LOC457262-2 HIST1H2BB HIST1H2BB LOC748495 LOC748495 HIST1H2BA HIST1H2BA H2AZ1 H2AZ1 KAT2B KAT2B EP300 EP300 E2F1 E2F1 HIST1H3A HIST1H3A NOTCH3 NOTCH3 SIRT6 SIRT6 KAT2A KAT2A TP53 TP53 H2AC7 H2AC7 LOC457262 LOC457262 H2AFX H2AFX MAML2 MAML2 LOC469702 LOC469702 MOV10 MOV10 AGO3 AGO3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPTRP00000086173annotation not available (566 aa)
ENSPTRP00000093891annotation not available (281 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
ENSPTRP00000092628annotation not available (129 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC471875Histone H3.1-like. (136 aa)
H2BC6Histone H2B type 1. (126 aa)
ENSPTRP00000090987annotation not available (87 aa)
E2F1-2E2F transcription factor 1. (437 aa)
LOC457262-10Histone H4. (103 aa)
H2BU1HIST3H2BB isoform 1. (126 aa)
ENSPTRP00000087746annotation not available (429 aa)
LOC457262-9Histone H4. (103 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
LOC462509HIST1H2BO isoform 1. (126 aa)
H3F3BH3 histone family member 3B. (136 aa)
H2BC14HIST1H2BM isoform 1. (126 aa)
TNRC6CTrinucleotide repeat containing adaptor 6C. (1943 aa)
LOC457262-8Histone H4. (103 aa)
CK820_G0031483H2AFV isoform 8. (118 aa)
ENSPTRP00000084305annotation not available (104 aa)
LOC457262-7Histone H4. (103 aa)
TFDP1Transcription factor. (352 aa)
ENSPTRP00000082196annotation not available (376 aa)
TNRC6BTNRC6B isoform 2. (1832 aa)
ENSPTRP00000081714annotation not available (310 aa)
MAMLD1-2Mastermind-like domain containing 1. (722 aa)
AGO1Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family. (860 aa)
MAML3MAML3 isoform 1. (1134 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
LOC457262-6Histone H4. (103 aa)
LOC107966300Histone H3. (136 aa)
ENSPTRP00000078054annotation not available (132 aa)
LOC457262-5Histone H4. (103 aa)
ELF3E74 like ETS transcription factor 3. (375 aa)
H4C8Histone H4. (103 aa)
LOC746430Uncharacterized LOC746430. (136 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
CREBBPCREB binding protein. (2442 aa)
LOC107971249-2Histone H2A-Bbd type 2/3. (115 aa)
LOC471883-2Histone H2B type 1. (126 aa)
LOC112209457-4Histone H3.1. (136 aa)
ENSPTRP00000074115annotation not available (54 aa)
TFDP2Transcription factor. (447 aa)
H2BC5HIST1H2BD isoform 1. (126 aa)
LOC471883Histone H2B type 1. (126 aa)
H2BC9HIST1H2BH isoform 1. (126 aa)
LOC104001083Histone H3.1. (136 aa)
LOC471880Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSPTRP00000069899annotation not available (273 aa)
H2AFV-2H2A histone family member V. (127 aa)
LOC457262-4Histone H4. (103 aa)
LOC471876Histone H3.1. (136 aa)
LOC746468HIST2H2AA3 isoform 1. (130 aa)
E2F3E2F transcription factor 3. (465 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
ENSPTRP00000065877annotation not available (115 aa)
ENSPTRP00000065421annotation not available (120 aa)
MAMLD1MAMLD1 isoform 3. (984 aa)
LOC457262-3Histone H4. (103 aa)
LOC104001101Histone H3.1. (136 aa)
SNW1SNW domain containing 1. (571 aa)
LOC112209457-2Histone H3.1. (136 aa)
LOC462508Histone H2B type 1-N. (167 aa)
LOC471907Histone H3.1. (104 aa)
LOC107971253Histone H2A-Bbd type 2/3. (115 aa)
H2AJH2AFJ isoform 2. (129 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
MAML1MAML1 isoform 1. (1016 aa)
H2BC21HIST2H2BE isoform 1. (126 aa)
HIST1H2AEHistone cluster 1 H2A family member e. (130 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
H3C13HIST2H3A isoform 1. (136 aa)
TFDP3Transcription factor. (405 aa)
TNRC6ATNRC6A isoform 3. (1937 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
LOC107971249Histone H2A; Belongs to the histone H2A family. (115 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (878 aa)
H2AFVH2AFV isoform 6. (128 aa)
H2AC14HIST1H2AJ isoform 1. (128 aa)
H2BC11HIST1H2BJ isoform 1. (126 aa)
H2AC6HIST1H2AC isoform 1. (130 aa)
LOC462501HIST1H2BK isoform 1. (126 aa)
LOC457262-2Histone H4. (103 aa)
HIST1H2BBHIST1H2BB isoform 1. (126 aa)
LOC748495HIST1H2AB isoform 1. (130 aa)
HIST1H2BAHIST1H2BA isoform 1. (127 aa)
H2AZ1H2AFZ isoform 3. (128 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
EP300E1A binding protein p300. (2175 aa)
E2F1E2F transcription factor 1. (437 aa)
HIST1H3AH3F3B isoform 13. (136 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
SIRT6SIRT6 isoform 1. (355 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
H2AC7Histone H2A type 1-D. (130 aa)
LOC457262HIST1H4A isoform 1. (103 aa)
H2AFXH2AFX isoform 1. (143 aa)
MAML2Mastermind like transcriptional coactivator 2. (1150 aa)
LOC469702Histone H2B type 3-A. (126 aa)
MOV10Mov10, Moloney leukemia virus 10, homolog. (1005 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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