STRINGSTRING
MTOR MTOR NRAS NRAS HRAS HRAS RPS6KB2 RPS6KB2 PAK1 PAK1 CBL CBL CDKN1B CDKN1B ERBB3 ERBB3 PAK6 PAK6 SHC4 SHC4 PRKCB PRKCB MAP2K4 MAP2K4 RPS6KB1 RPS6KB1 PRKCA PRKCA GRB2 GRB2 MAP2K2 MAP2K2 PIK3R2 PIK3R2 PRKCG PRKCG NCK2 NCK2 PAK5 PAK5 PLCG1 PLCG1 MAPK1 MAPK1 CBLB CBLB NCK1 NCK1 PIK3CB PIK3CB EREG EREG BTC BTC EGF EGF GAB1 GAB1 HBEGF HBEGF MAPK9 MAPK9 ELK1 ELK1 MAPK8 MAPK8 NRG2 NRG2 SOS2 SOS2 CRKL CRKL SHC1 SHC1 SOS1 SOS1 MAPK3 MAPK3 CDKN1A CDKN1A AREG AREG PAK3 PAK3 MAP2K1 MAP2K1 ERBB4 ERBB4 SHC3 SHC3 PIK3R3 PIK3R3 EGFR EGFR ERBB2 ERBB2 MAPK10 MAPK10 NRG3 NRG3 ABL1 ABL1 CAMK2B CAMK2B MYC MYC PLCG2 PLCG2 SRC SRC PIK3R1 PIK3R1 BRAF BRAF CAMK2A CAMK2A NRG4 NRG4 GSK3B GSK3B AKT1 AKT1 CRK CRK ARAF ARAF KRAS KRAS AKT3 AKT3 AKT2 AKT2 PAK4 PAK4 NRG1 NRG1 ABL2 ABL2 BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
ERBB3V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian). (1353 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
SHC4SHC adaptor protein 4. (630 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
NCK2Cytoplasmic protein. (380 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
NCK1Cytoplasmic protein. (377 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
EREGEREG isoform 1. (169 aa)
BTCBTC isoform 1. (178 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
HBEGFHeparin-binding EGF-like growth factor. (208 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ELK1ELK1, member of ETS oncogene family. (428 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NRG2NRG2 isoform 3. (859 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
AREGAREG isoform 2. (274 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
SHC3SHC3 isoform 2. (598 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
NRG3NRG3 isoform 3. (721 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
NRG4NRG4 isoform 3. (117 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
ARAFV-raf murine sarcoma 3611 viral oncogene homolog. (606 aa)
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
NRG1NRG1 isoform 3. (713 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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