(52 nodes) Response to activity network (Pongo abelii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RYR2	RYR2 isoform 1. (4546 aa)
	MYOG	MYOG isoform 1. (224 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (274 aa)
	PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa)
	FNDC5	FNDC5 isoform 3. (180 aa)
	SELENON	T0151383 isoform 1. (556 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1125 aa)
	TH	TH isoform 6. (522 aa)
	SMTNL1	SMTNL1 isoform 1. (456 aa)
	CRY2	Cryptochrome circadian regulator 2. (593 aa)
	UCP3	Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
	CBL	Cbl proto-oncogene. (905 aa)
	TPH2	Tryptophan hydroxylase 2. (490 aa)
	CRY1	Cryptochrome circadian regulator 1. (586 aa)
	KL	KL isoform 1. (988 aa)
	COL4A2	COL4A2 isoform 1. (1694 aa)
	CR201_G0009767	HIF1A isoform 5. (735 aa)
	CAPN3	CAPN3 isoform 16; Belongs to the peptidase C2 family. (815 aa)
	MMP2	MMP2 isoform 3. (559 aa)
	SLC7A5	Solute carrier family 7 member 5. (507 aa)
	ENSPPYP00000008618	annotation not available (118 aa)
	METRNL	METRNL isoform 1. (255 aa)
	ITGB3	Integrin beta. (788 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	OXT	Oxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
	ADSL	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (484 aa)
	ABCG8	ABCG8 isoform 1. (601 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (651 aa)
	GCG	GCG isoform 1. (180 aa)
	FN1	FN1 isoform 4. (2445 aa)
	PRKAG3	PRKAG3 isoform 1. (489 aa)
	CAB39	Calcium binding protein 39. (341 aa)
	UQCRC1	Ubiquinol-cytochrome c reductase core protein 1. (480 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (798 aa)
	HADH	Hydroxyacyl-CoA dehydrogenase. (314 aa)
	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (168 aa)
	OXCT1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (520 aa)
	ITGA2	ITGA2 isoform 1; Belongs to the integrin alpha chain family. (1157 aa)
	BMP6	BMP6 isoform 1. (510 aa)
	EDN1	EDN1 isoform 1. (212 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (637 aa)
	MGRA	Mas-related G protein-coupled receptor A; Belongs to the G-protein coupled receptor 1 family. (325 aa)
	NPC1L1	NPC1L1 isoform 2. (1326 aa)
	IL6	IL6 isoform 2. (212 aa)
	ANGPT2	ANGPT2 isoform 3. (495 aa)
	HSF1	HSF1 isoform 2. (594 aa)
	SLC25A25	Solute carrier family 25 member 25; Belongs to the mitochondrial carrier (TC 2.A.29) family. (503 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
	MTFP1	Mitochondrial fission process protein 1 isoform X1. (149 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG5	ABCG8	ENSPPYP00000013911	ENSPPYP00000013910	ATP binding cassette subfamily G member 5.	ABCG8 isoform 1.	0.999
ABCG5	NPC1L1	ENSPPYP00000013911	ENSPPYP00000019716	ATP binding cassette subfamily G member 5.	NPC1L1 isoform 2.	0.709
ABCG8	ABCG5	ENSPPYP00000013910	ENSPPYP00000013911	ABCG8 isoform 1.	ATP binding cassette subfamily G member 5.	0.999
ABCG8	NPC1L1	ENSPPYP00000013910	ENSPPYP00000019716	ABCG8 isoform 1.	NPC1L1 isoform 2.	0.706
ADIPOQ	EDN1	ENSPPYP00000016092	ENSPPYP00000018159	Adiponectin, C1Q and collagen domain containing.	EDN1 isoform 1.	0.414
ADIPOQ	FGF21	ENSPPYP00000016092	ENSPPYP00000011424	Adiponectin, C1Q and collagen domain containing.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.581
ADIPOQ	FNDC5	ENSPPYP00000016092	ENSPPYP00000001826	Adiponectin, C1Q and collagen domain containing.	FNDC5 isoform 3.	0.497
ADIPOQ	GCG	ENSPPYP00000016092	ENSPPYP00000014379	Adiponectin, C1Q and collagen domain containing.	GCG isoform 1.	0.577
ADIPOQ	IL6	ENSPPYP00000016092	ENSPPYP00000019884	Adiponectin, C1Q and collagen domain containing.	IL6 isoform 2.	0.681
ADIPOQ	PPARD	ENSPPYP00000016092	ENSPPYP00000018484	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator activated receptor delta.	0.463
ADIPOQ	PPARGC1A	ENSPPYP00000016092	ENSPPYP00000016357	Adiponectin, C1Q and collagen domain containing.	PPARG coactivator 1 alpha.	0.757
ADIPOQ	STK11	ENSPPYP00000016092	ENSPPYP00000010446	Adiponectin, C1Q and collagen domain containing.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.434
ADIPOQ	UCP3	ENSPPYP00000016092	ENSPPYP00000004193	Adiponectin, C1Q and collagen domain containing.	Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.418
ADSL	OXCT1	ENSPPYP00000013221	ENSPPYP00000017238	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.570
ANGPT2	CR201_G0009767	ENSPPYP00000020527	ENSPPYP00000006683	ANGPT2 isoform 3.	HIF1A isoform 5.	0.457
ANGPT2	EDN1	ENSPPYP00000020527	ENSPPYP00000018159	ANGPT2 isoform 3.	EDN1 isoform 1.	0.683
ANGPT2	IL6	ENSPPYP00000020527	ENSPPYP00000019884	ANGPT2 isoform 3.	IL6 isoform 2.	0.562
ANGPT2	MMP2	ENSPPYP00000020527	ENSPPYP00000008311	ANGPT2 isoform 3.	MMP2 isoform 3.	0.464
BMP6	IL6	ENSPPYP00000018132	ENSPPYP00000019884	BMP6 isoform 1.	IL6 isoform 2.	0.532
CAB39	PRKAA2	ENSPPYP00000014820	ENSPPYP00000001519	Calcium binding protein 39.	5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...]	0.952