STRINGSTRING
ERLIN1 ERLIN1 SYVN1 SYVN1 RNF121 RNF121 UBE4A UBE4A OS9 OS9 PSMC6 PSMC6 JKAMP JKAMP SEL1L SEL1L SELENOS SELENOS STUB1 STUB1 UMOD UMOD AMFR AMFR DERL2 DERL2 TRIM25 TRIM25 TMUB2 TMUB2 CCDC47 CCDC47 SGTA SGTA CALR CALR CALR3 CALR3 FBXO17 FBXO17 FBXO27 FBXO27 NCCRP1 NCCRP1 EDEM2 EDEM2 UBE2G2 UBE2G2 UFD1 UFD1 DERL3 DERL3 RNF185 RNF185 FOXRED2 FOXRED2 RNF103 RNF103 AUP1 AUP1 ERLEC1 ERLEC1 UBXN4 UBXN4 DNAJC10 DNAJC10 ANKZF1 ANKZF1 DNAJB2 DNAJB2 FAM8A1 FAM8A1 BAG6 BAG6 RNF5 RNF5 UBE2J1 UBE2J1 MAN1A1 MAN1A1 RHBDD2 RHBDD2 DNAJB9 DNAJB9 TMUB1 TMUB1 UBXN8 UBXN8 ERLIN2 ERLIN2 TMEM67 TMEM67 DERL1 DERL1 VCP VCP UBQLN1 UBQLN1 SEC61B SEC61B MAN1B1 MAN1B1 UBQLN2 UBQLN2 HSP90B1 HSP90B1 NPLOC4 NPLOC4 FAF1 FAF1 UBE2J2 UBE2J2 YOD1 YOD1 EDEM3 EDEM3 ENSPPYP00000001345 ENSPPYP00000001345 UBXN10 UBXN10 FBXO6 FBXO6 DNAJB12 DNAJB12 FBXO44 FBXO44 FBXO2 FBXO2 UBE4B UBE4B EDEM1 EDEM1 USP19 USP19 STT3B STT3B TMEM129 TMEM129 WFS1 WFS1 CLGN CLGN RNF175 RNF175 TTC33 TTC33 SGTB SGTB DNAJC18 DNAJC18 FAF2 FAF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERLIN1Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity). (341 aa)
SYVN1SYVN1 isoform 3. (616 aa)
RNF121Ring finger protein 121. (327 aa)
UBE4AUbiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. (1072 aa)
OS9OS9 isoform 1. (611 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
JKAMPJNK1/MAPK8 associated membrane protein. (311 aa)
SEL1LSEL1L isoform 1. (738 aa)
SELENOSSELENOS isoform 1. (188 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
UMODUromodulin, secreted form; [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. (641 aa)
AMFRAMFR isoform 1. (548 aa)
DERL2Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...] (239 aa)
TRIM25Tripartite motif containing 25. (630 aa)
TMUB2Transmembrane and ubiquitin like domain containing 2. (321 aa)
CCDC47Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis (By similarity). (483 aa)
SGTASmall glutamine rich tetratricopeptide repeat containing alpha. (313 aa)
CALRCalreticulin. (417 aa)
CALR3Calreticulin. (319 aa)
FBXO17F-box only protein 17. (278 aa)
FBXO27FBXO27 isoform 2. (267 aa)
NCCRP1NCCRP1 isoform 1. (275 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (512 aa)
UBE2G2Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). (165 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (231 aa)
RNF185E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UB [...] (192 aa)
FOXRED2FOXRED2 isoform 1. (684 aa)
RNF103Charged multivesicular body protein 3. (685 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (410 aa)
ERLEC1Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non- glycosylated proteins and glycoproteins (By similarity). (471 aa)
UBXN4UBX domain-containing protein 4; Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. (482 aa)
DNAJC10DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, [...] (793 aa)
ANKZF1ANKZF1 isoform 15. (776 aa)
DNAJB2DNAJB2 isoform 1. (298 aa)
FAM8A1RDD domain-containing protein. (413 aa)
BAG6BCL2 associated athanogene 6. (1126 aa)
RNF5Ring finger protein 5. (180 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)
MAN1A1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (813 aa)
RHBDD2Rhomboid domain containing 2. (364 aa)
DNAJB9DnaJ homolog subfamily B member 9; Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (By similarity). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similar [...] (223 aa)
TMUB1TMUB1 isoform 1. (321 aa)
UBXN8UBXN8 isoform 1. (246 aa)
ERLIN2Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol- accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). (380 aa)
TMEM67Transmembrane protein 67. (995 aa)
DERL1Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre- emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for pro [...] (201 aa)
VCPTransitional endoplasmic reticulum ATPase isoform X1. (806 aa)
UBQLN1Ubiquilin-1; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a lin [...] (577 aa)
SEC61BProtein transport protein Sec61 subunit beta; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis (By similarity). (96 aa)
MAN1B1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (699 aa)
UBQLN2UBQLN2 isoform 1. (624 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (773 aa)
NPLOC4NPLOC4 isoform 1. (609 aa)
FAF1Fas associated factor 1. (650 aa)
UBE2J2Ubiquitin conjugating enzyme E2 J2. (259 aa)
YOD1YOD1 deubiquitinase. (348 aa)
EDEM3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (932 aa)
ENSPPYP00000001345annotation not available (371 aa)
UBXN10UBXN10 isoform 1. (280 aa)
FBXO6F-box protein 6. (293 aa)
DNAJB12DnaJ heat shock protein family (Hsp40) member B12. (409 aa)
FBXO44F-box protein 44. (224 aa)
FBXO2F-box protein 2. (295 aa)
UBE4BUBE4B isoform 1. (1106 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (656 aa)
USP19USP19 isoform 8. (1313 aa)
STT3BSTT3 oligosaccharyltransferase complex catalytic subunit B. (826 aa)
TMEM129Transmembrane protein 129. (362 aa)
WFS1WFS1 isoform 1. (964 aa)
CLGNCLGN isoform 1. (542 aa)
RNF175RNF175 isoform 1. (329 aa)
TTC33Tetratricopeptide repeat domain 33. (262 aa)
SGTBSmall glutamine rich tetratricopeptide repeat containing beta. (304 aa)
DNAJC18DNAJC18 isoform 5. (344 aa)
FAF2Fas associated factor family member 2. (445 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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