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EGLN2 EGLN2 EGLN1 EGLN1 SELP SELP CR201_G0041993 CR201_G0041993 CR201_G0036500 CR201_G0036500 PLOD1 PLOD1 PHYH PHYH MRC1 MRC1 ENSPPYP00000002671 ENSPPYP00000002671 P4HA1 P4HA1 HK1 HK1 HKDC1 HKDC1 MBL2 MBL2 ENSPPYP00000003276 ENSPPYP00000003276 TALDO1 TALDO1 ALKBH3 ALKBH3 P4HA3 P4HA3 P3H3 P3H3 SLC2A14 SLC2A14 SLC2A3 SLC2A3 CLEC4A CLEC4A CLEC6A CLEC6A OGFOD2 OGFOD2 EGLN3 EGLN3 PYGL PYGL LMAN1L LMAN1L METTL26 METTL26 OGFOD1 OGFOD1 LGALS9 LGALS9 PIGS PIGS P3H4 P3H4 GALK1 GALK1 OGFOD3 OGFOD3 BSG BSG CLEC4G CLEC4G CD209 CD209 ENSPPYP00000010643 ENSPPYP00000010643 CR201_G0037575 CR201_G0037575 DPM1 DPM1 PFKL PFKL ACR ACR RPIA RPIA HK2 HK2 CD207 CD207 UGP2 UGP2 COLEC11 COLEC11 CRTAP CRTAP MANBA MANBA ALPK1 ALPK1 PAM PAM P4HA2 P4HA2 HK3 HK3 LMAN2 LMAN2 IGF2R IGF2R PLOD3 PLOD3 GCK GCK COLEC10 COLEC10 FBP1 FBP1 ALDOB ALDOB SLC2A8 SLC2A8 ENG ENG DBH DBH G6PD G6PD PLOD2 PLOD2 ALDOA ALDOA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGLN2T0155508 isoform 1. (407 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
SELPSELP isoform 2. (829 aa)
CR201_G0041993P3H1 isoform 2. (560 aa)
CR201_G0036500FUOM isoform 1. (109 aa)
PLOD1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). (727 aa)
PHYHPHYH isoform 3. (340 aa)
MRC1MRC1 isoform 1. (1455 aa)
ENSPPYP00000002671LOW QUALITY PROTEIN: mannose-binding protein A-like. (187 aa)
P4HA1Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. (534 aa)
HK1Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] (917 aa)
HKDC1Hexokinase domain containing 1. (916 aa)
MBL2MBL2 isoform 1. (248 aa)
ENSPPYP00000003276annotation not available (165 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
ALKBH3AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (295 aa)
P4HA3Prolyl 4-hydroxylase subunit alpha 3. (544 aa)
P3H3P3H3 isoform 1. (737 aa)
SLC2A14Solute carrier family 2, facilitated glucose transporter member 3; Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. (496 aa)
SLC2A3Pongo abelii solute carrier family 2 member 3 (SLC2A3), mRNA. (422 aa)
CLEC4AT0128230 isoform 1. (237 aa)
CLEC6AC-type lectin domain containing 6A. (208 aa)
OGFOD22-oxoglutarate and iron dependent oxygenase domain containing 2. (350 aa)
EGLN3EGLN3 isoform 1. (239 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
LMAN1LLMAN1L isoform 2. (468 aa)
METTL26METTL26 isoform 12. (205 aa)
OGFOD1Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro- 62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family. (542 aa)
LGALS9Galectin. (323 aa)
PIGSPIGS isoform 2. (550 aa)
P3H4P3H4 isoform 2. (230 aa)
GALK1GALK1 isoform 1. (392 aa)
OGFOD3OGFOD3 isoform 4. (331 aa)
BSGBSG isoform 4. (264 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
CD209CD209 isoform 2. (404 aa)
ENSPPYP00000010643annotation not available (74 aa)
CR201_G0037575CLEC17A isoform 1. (262 aa)
DPM1Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. (260 aa)
PFKLATP-dependent 6-phosphofructokinase, liver type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). Belongs to the phosphofructokinase typ [...] (697 aa)
ACRACR isoform 2; Belongs to the peptidase S1 family. (349 aa)
RPIARPIA isoform 1. (311 aa)
HK2HK2 isoform 1. (896 aa)
CD207CD207 isoform 1. (239 aa)
UGP2UTP--glucose-1-phosphate uridylyltransferase. (497 aa)
COLEC11Collectin subfamily member 11. (271 aa)
CRTAPCRTAP isoform 1. (399 aa)
MANBAMANBA isoform 1. (879 aa)
ALPK1ALPK1 isoform 3. (1181 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (973 aa)
P4HA2Prolyl 4-hydroxylase subunit alpha 2. (533 aa)
HK3HK3 isoform 2. (923 aa)
LMAN2Lectin, mannose binding 2. (356 aa)
IGF2RIGF2R isoform 1. (2446 aa)
PLOD3Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; Multifunctional enzyme that catalyzes a series of post- translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosy [...] (738 aa)
GCKPhosphotransferase. (464 aa)
COLEC10Collectin subfamily member 10. (277 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
ALDOBFructose-bisphosphate aldolase B. (364 aa)
SLC2A8SLC2A8 isoform 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
ENGENG isoform 3. (668 aa)
DBHDBH isoform 1. (615 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (543 aa)
PLOD2PLOD2 isoform 2. (385 aa)
ALDOAFructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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