STRINGSTRING
DLL4 DLL4 CR201_G0011157 CR201_G0011157 NOTCH1 NOTCH1 LHX3 LHX3 TGFBR1 TGFBR1 DMRT3 DMRT3 EYA1 EYA1 NRG1 NRG1 MNX1 MNX1 SHH SHH GBX1 GBX1 GLI3 GLI3 DLL1 DLL1 OLIG3 OLIG3 ENSPPYP00000018739 ENSPPYP00000018739 EHMT2 EHMT2 TLX3 TLX3 ISL1 ISL1 ATOH1 ATOH1 GSX2 GSX2 CTNNB1 CTNNB1 FEZF2 FEZF2 GATA2 GATA2 IHH IHH FEV FEV HOXD10 HOXD10 DLX2 DLX2 DLX1 DLX1 TBR1 TBR1 GLI2 GLI2 ID2 ID2 MYT1L MYT1L OLIG2 OLIG2 NKX2-2 NKX2-2 FKBP8 FKBP8 NOTCH3 NOTCH3 SMAD4 SMAD4 ZNF521 ZNF521 SOX9 SOX9 ISL2 ISL2 ENSPPYP00000007046 ENSPPYP00000007046 BCL11B BCL11B BMP4 BMP4 FOXA1 FOXA1 NKX2-1 NKX2-1 FOXG1 FOXG1 SOX1 SOX1 ENSPPYP00000006185 ENSPPYP00000006185 GSX1 GSX1 FOXN4 FOXN4 ASCL1 ASCL1 HOXC10 HOXC10 WNT1 WNT1 DBX1 DBX1 PAX6 PAX6 NKX6-2 NKX6-2 SUFU SUFU LBX1 LBX1 PTF1A PTF1A CDC42 CDC42 DMRTA2 DMRTA2 PRRX1 PRRX1 PROX1 PROX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
CR201_G0011157PAX6 isoform 63. (257 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
LHX3LHX3 isoform 2. (402 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
DMRT3DMRT3 isoform 1. (131 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
NRG1NRG1 isoform 10. (692 aa)
MNX1MNX1 isoform 4. (363 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa)
GBX1GBX1 isoform 1. (203 aa)
GLI3GLI3 isoform 3. (1580 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
ENSPPYP00000018739annotation not available (186 aa)
EHMT2EHMT2 isoform 5. (1267 aa)
TLX3TLX3 isoform 1. (338 aa)
ISL1ISL1 isoform 1. (349 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
GSX2GSX2 isoform 2. (305 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
FEZF2FEZ family zinc finger 2. (460 aa)
GATA2GATA2 isoform 1. (408 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
FEVFEV isoform 1. (239 aa)
HOXD10HOXD10 isoform 3. (340 aa)
DLX2Distal-less homeobox 2. (328 aa)
DLX1Distal-less homeobox 1. (255 aa)
TBR1T-box brain transcription factor 1. (682 aa)
GLI2GLI2 isoform 1. (1521 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
MYT1LMYT1L isoform 3. (1184 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ZNF521ZNF521 isoform 3. (1311 aa)
SOX9SRY-box transcription factor 9. (509 aa)
ISL2ISL LIM homeobox 2. (359 aa)
ENSPPYP00000007046annotation not available (868 aa)
BCL11BBCL11B isoform 1. (893 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FOXA1FOXA1 isoform 1. (448 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
FOXG1FOXG1 isoform 8. (440 aa)
SOX1SOX1 isoform 1. (372 aa)
ENSPPYP00000006185annotation not available (303 aa)
GSX1GSX1 isoform 1. (264 aa)
FOXN4FOXN4 isoform 1. (517 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (235 aa)
HOXC10Homeobox protein Hox-C10. (342 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DBX1Developing brain homeobox 1. (381 aa)
PAX6PAX6 isoform 13. (266 aa)
NKX6-2NKX6-2 isoform 2. (277 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
LBX1Ladybird homeobox 1. (281 aa)
PTF1APTF1A isoform 1. (422 aa)
CDC42Cell division cycle 42. (191 aa)
DMRTA2DMRTA2 isoform 1. (465 aa)
PRRX1PRRX1 isoform 3. (216 aa)
PROX1Prospero homeobox 1. (737 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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