STRINGSTRING
NOG NOG SOX8 SOX8 GREM1 GREM1 SIX1 SIX1 PAX2 PAX2 GATA3 GATA3 HS2ST1 HS2ST1 IRX1 IRX1 GDNF GDNF IRX2 IRX2 CTNNB1 CTNNB1 WNT6 WNT6 OSR1 OSR1 SOX9 SOX9 WNT9B WNT9B IRX3 IRX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SOX8SRY-box transcription factor 8. (446 aa)
GREM1Gremlin. (184 aa)
SIX1SIX homeobox 1. (284 aa)
PAX2PAX2 isoform 3. (388 aa)
GATA3GATA binding protein 3. (444 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand- binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Belongs to the sulfotransferase 3 family. (359 aa)
IRX1Iroquois-class homeodomain protein IRX-1. (480 aa)
GDNFGDNF isoform 6. (185 aa)
IRX2Iroquois homeobox 2. (472 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
OSR1OSR1 isoform 1. (265 aa)
SOX9SRY-box transcription factor 9. (509 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
IRX3IRX3 isoform 1. (436 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.