(6 nodes) Mixed, incl. tRNA-guanine transglycosylation, and Positive regulation of insulin receptor signaling pathway network (Homo sapiens)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ANKRD7	Ankyrin repeat domain 7. (254 aa)
	TSACC	TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family. (125 aa)
	C9orf64	Queuosine salvage protein; Involved in salvaging queuosine. (341 aa)
	GKAP1	G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. (366 aa)
	C22orf23	UPF0193 protein EVG1; Chromosome 22 open reading frame 23. (217 aa)
	C2CD6	C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6. (1820 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD7	C2CD6	ENSP00000265224	ENSP00000409937	Ankyrin repeat domain 7.	C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6.	0.445
ANKRD7	TSACC	ENSP00000265224	ENSP00000357238	Ankyrin repeat domain 7.	TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family.	0.456
C22orf23	C2CD6	ENSP00000384667	ENSP00000409937	UPF0193 protein EVG1; Chromosome 22 open reading frame 23.	C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6.	0.540
C22orf23	GKAP1	ENSP00000384667	ENSP00000365550	UPF0193 protein EVG1; Chromosome 22 open reading frame 23.	G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.	0.507
C22orf23	TSACC	ENSP00000384667	ENSP00000357238	UPF0193 protein EVG1; Chromosome 22 open reading frame 23.	TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family.	0.663
C2CD6	ANKRD7	ENSP00000409937	ENSP00000265224	C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6.	Ankyrin repeat domain 7.	0.445
C2CD6	C22orf23	ENSP00000409937	ENSP00000384667	C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6.	UPF0193 protein EVG1; Chromosome 22 open reading frame 23.	0.540
C2CD6	GKAP1	ENSP00000409937	ENSP00000365550	C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6.	G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.	0.480
C2CD6	TSACC	ENSP00000409937	ENSP00000357238	C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6.	TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family.	0.568
C9orf64	GKAP1	ENSP00000365522	ENSP00000365550	Queuosine salvage protein; Involved in salvaging queuosine.	G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.	0.557
GKAP1	C22orf23	ENSP00000365550	ENSP00000384667	G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.	UPF0193 protein EVG1; Chromosome 22 open reading frame 23.	0.507
GKAP1	C2CD6	ENSP00000365550	ENSP00000409937	G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.	C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6.	0.480
GKAP1	C9orf64	ENSP00000365550	ENSP00000365522	G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.	Queuosine salvage protein; Involved in salvaging queuosine.	0.557
GKAP1	TSACC	ENSP00000365550	ENSP00000357238	G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.	TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family.	0.522
TSACC	ANKRD7	ENSP00000357238	ENSP00000265224	TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family.	Ankyrin repeat domain 7.	0.456
TSACC	C22orf23	ENSP00000357238	ENSP00000384667	TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family.	UPF0193 protein EVG1; Chromosome 22 open reading frame 23.	0.663
TSACC	C2CD6	ENSP00000357238	ENSP00000409937	TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family.	C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6.	0.568
TSACC	GKAP1	ENSP00000357238	ENSP00000365550	TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family.	G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.	0.522