STRINGSTRING
MS4A12 MS4A12 RIN3 RIN3 ABI3 ABI3 IRGC IRGC SPPL2A SPPL2A ABCA7 ABCA7 ABI3BP ABI3BP SPPL3 SPPL3 NYAP1 NYAP1 MS4A6E MS4A6E MS4A5 MS4A5 MS4A8 MS4A8 C1QTNF4 C1QTNF4 MAP6 MAP6 MS4A10 MS4A10 BIN1 BIN1 ITM2C ITM2C MTSS1 MTSS1 PCSK7 PCSK7 C6orf58 C6orf58 CLPTM1 CLPTM1 MS4A4A MS4A4A FERMT2 FERMT2 CASS4 CASS4 ECHDC3 ECHDC3 SYAP1 SYAP1 TMEM106B TMEM106B ZCWPW1 ZCWPW1 MS4A15 MS4A15 TMEM106C TMEM106C TMEM176B TMEM176B TMEM176A TMEM176A CR1L CR1L MS4A18 MS4A18 SLC24A4 SLC24A4 MS4A14 MS4A14 SOGA3 SOGA3 KIAA0408 KIAA0408 MS4A6A MS4A6A ARHGAP45 ARHGAP45 FAM180B FAM180B SCIMP SCIMP ANKRD24 ANKRD24 SPPL2B SPPL2B ENSP00000487717 ENSP00000487717 OOSP4B OOSP4B ITM2B ITM2B MS4A4E MS4A4E
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MS4A12Membrane-spanning 4-domains subfamily A member 12; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. (267 aa)
RIN3Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function; Belongs to the RIN (Ras interaction/interference) family. (985 aa)
ABI3ABI gene family member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility; Belongs to the ABI family. (366 aa)
IRGCInterferon-inducible GTPase 5; Immunity related GTPase cinema. (463 aa)
SPPL2ASignal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and [...] (520 aa)
ABCA7Phospholipid-transporting ATPase ABCA7; Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Transports preferentially phosphatidylserine over phosphatidylcholine. Plays a role in lipid homeostasis and macrophage- mediated phagocytosis. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocyte differentiation. Involved in lipid raft organization and CD1D [...] (2146 aa)
ABI3BPTarget of Nesh-SH3; ABI family member 3 binding protein. (1075 aa)
SPPL3Signal peptide peptidase-like 3; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1. Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furi [...] (384 aa)
NYAP1Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. Belongs to the NYAP family. (841 aa)
MS4A6EMembrane-spanning 4-domains subfamily A member 6E; May be involved in signal transduction as a component of a multimeric receptor complex. (147 aa)
MS4A5Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex. (200 aa)
MS4A8Membrane-spanning 4-domains subfamily A member 8; May be involved in signal transduction as a component of a multimeric receptor complex. (250 aa)
C1QTNF4Complement C1q tumor necrosis factor-related protein 4; May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent. Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity). (329 aa)
MAP6Microtubule-associated protein 6; Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B. Regulates KIF5A- mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). Belongs to the STOP family. (813 aa)
MS4A10Membrane-spanning 4-domains subfamily A member 10; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. (267 aa)
BIN1Myc box-dependent-interacting protein 1; Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau [...] (593 aa)
ITM2CIntegral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). (267 aa)
MTSS1Protein MTSS 1; May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. (759 aa)
PCSK7Proprotein convertase subtilisin/kexin type 7; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway. (785 aa)
C6orf58Protein LEG1 homolog; May be involved in early liver development. (330 aa)
CLPTM1Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. (669 aa)
MS4A4AMembrane-spanning 4-domains subfamily A member 4A; May be involved in signal transduction as a component of a multimeric receptor complex. (239 aa)
FERMT2Fermitin family homolog 2; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and ce [...] (687 aa)
CASS4Cas scaffolding protein family member 4; Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. (786 aa)
ECHDC3Enoyl-CoA hydratase domain-containing protein 3, mitochondrial; May play a role in fatty acid biosynthesis and insulin sensitivity; Belongs to the enoyl-CoA hydratase/isomerase family. (303 aa)
SYAP1Synapse-associated protein 1; Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation. (352 aa)
TMEM106BTransmembrane protein 106B; Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching. (274 aa)
ZCWPW1Zinc finger CW-type and PWWP domain containing 1. (648 aa)
MS4A15Membrane-spanning 4-domains subfamily A member 15; May be involved in signal transduction as a component of a multimeric receptor complex. (240 aa)
TMEM106CTransmembrane protein 106C. (250 aa)
TMEM176BTransmembrane protein 176B; May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). (270 aa)
TMEM176ATransmembrane protein 176A. (235 aa)
CR1LComplement component receptor 1-like protein; Complement C3b/C4b receptor 1 like; Belongs to the receptors of complement activation (RCA) family. (569 aa)
MS4A18Membrane spanning 4-domains A18. (400 aa)
SLC24A4Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. (622 aa)
MS4A14Membrane-spanning 4-domains subfamily A member 14; May be involved in signal transduction as a component of a multimeric receptor complex. (712 aa)
SOGA3Protein SOGA3; SOGA family member 3. (947 aa)
KIAA0408Uncharacterized protein KIAA0408; KIAA0408. (694 aa)
MS4A6AMembrane-spanning 4-domains subfamily A member 6A; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. (276 aa)
ARHGAP45Minor histocompatibility antigen HA-1; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR- domin which is able to play an autoinhibitory effect on this RhoGAP activity. (1152 aa)
FAM180BProtein FAM180B; Family with sequence similarity 180 member B. (183 aa)
SCIMPSLP adapter and CSK-interacting membrane protein; Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells. It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible si [...] (145 aa)
ANKRD24Ankyrin repeat domain 24. (1146 aa)
SPPL2BSignal peptide peptidase-like 2B; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependen [...] (592 aa)
ENSP00000487717Uncharacterized protein. (310 aa)
OOSP4BOocyte secreted protein family member 4B. (160 aa)
ITM2BIntegral membrane protein 2B; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers; Belongs to the ITM2 family. (266 aa)
MS4A4EPutative membrane-spanning 4-domains subfamily A member 4E; Membrane spanning 4-domains A4E; Belongs to the MS4A family. (331 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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