STRINGSTRING
TAX1BP3 TAX1BP3 PRRX1 PRRX1 METTL25 METTL25 AAGAB AAGAB METTL2B METTL2B METTL21C METTL21C IGSF6 IGSF6 OSR1 OSR1 METTL21A METTL21A PPM1B PPM1B CMBL CMBL METTL27 METTL27 SMCO4 SMCO4 EEF1AKMT3 EEF1AKMT3 OR8U1 OR8U1 NUDCD2 NUDCD2 METTL18 METTL18 METTL2A METTL2A HEPHL1 HEPHL1 EEF1AKMT4 EEF1AKMT4 KLHL38 KLHL38 TRIM55 TRIM55 C11orf54 C11orf54 TMEM104 TMEM104 KLHL33 KLHL33 METTL24 METTL24 DALRD3 DALRD3 ECE2 ECE2 ETFBKMT ETFBKMT METTL9 METTL9 HSD17B11 HSD17B11 DUSP27 DUSP27 EEF1AKNMT EEF1AKNMT RRNAD1 RRNAD1 EEF1AKMT2 EEF1AKMT2 KLHL31 KLHL31 OR2W1 OR2W1 CAMKMT CAMKMT KIN KIN METTL22 METTL22 EEF1AKMT1 EEF1AKMT1 METTL7B METTL7B VCPKMT VCPKMT ZNF676 ZNF676 ZNF195 ZNF195 KLHL30 KLHL30 PREPL PREPL VSTM5 VSTM5 EEF2KMT EEF2KMT IQCD IQCD METTL11B METTL11B FBXO24 FBXO24 ATPSCKMT ATPSCKMT E9PBE3_HUMAN E9PBE3_HUMAN ZNF721 ZNF721 CSKMT CSKMT F5H423_HUMAN F5H423_HUMAN METTL26 METTL26 METTL7A METTL7A CCDC32 CCDC32 ANTKMT ANTKMT K7EN84_HUMAN K7EN84_HUMAN K7ERJ3_HUMAN K7ERJ3_HUMAN ALG1L2 ALG1L2 METTL8 METTL8 METTL23 METTL23 NTMT1 NTMT1 C8orf89 C8orf89
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. (124 aa)
PRRX1Paired mesoderm homeobox protein 1; Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity); Belongs to the paired homeobox family. (245 aa)
METTL25Methyltransferase-like protein 25; Putative methyltransferase. (603 aa)
AAGABAlpha- and gamma-adaptin-binding protein p34; May be involved in endocytic recycling of growth factor receptors such as EGFR. (315 aa)
METTL2BtRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family. (378 aa)
METTL21CProtein-lysine methyltransferase METTL21C; Protein-lysine methyltransferase. Belongs to the methyltransferase superfamily. METTL21 family. (264 aa)
IGSF6Immunoglobulin superfamily member 6. (241 aa)
OSR1Protein odd-skipped-related 1; Transcription factor that plays a role in the regulation of embryonic heart and urogenital development. (266 aa)
METTL21AProtein N-lysine methyltransferase METTL21A; Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8. (236 aa)
PPM1BProtein phosphatase 1B; Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1- mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF- kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. (479 aa)
CMBLCarboxymethylenebutenolidase homolog; Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. (245 aa)
METTL27Methyltransferase-like protein 27; Methyltransferase like 27. (245 aa)
SMCO4Single-pass membrane protein with coiled-coil domains 4; Belongs to the SMCO4 family. (59 aa)
EEF1AKMT3EEF1A lysine methyltransferase 3; Protein-lysine methyltransferase that selectively methylates EEF1A1 and EEF1A2 at 'Lys-165' in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation; Belongs to the methyltransferase superfamily. METTL21 family. (226 aa)
OR8U1Olfactory receptor 8U1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (309 aa)
NUDCD2NudC domain-containing protein 2; May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. (157 aa)
METTL18Histidine protein methyltransferase 1 homolog; Probable histidine methyltransferase; Belongs to the methyltransferase superfamily. METTL18 family. (372 aa)
METTL2AtRNA N(3)-methylcytidine methyltransferase METTL2A; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Belongs to the methyltransferase superfamily. METL family. (378 aa)
HEPHL1Ferroxidase HEPHL1; Is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe(2+) to Fe(3+) without releasing radical oxygen species. May be involved in the regulation of intracellular iron content. (1159 aa)
EEF1AKMT4EEF1A lysine methyltransferase 4; Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2). (255 aa)
KLHL38Kelch-like protein 38; Kelch like family member 38. (581 aa)
TRIM55Tripartite motif-containing protein 55; May regulate gene expression and protein turnover in muscle cells. (548 aa)
C11orf54Ester hydrolase C11orf54; Exhibits ester hydrolase activity on the substrate p- nitrophenyl acetate. (315 aa)
TMEM104Transmembrane protein 104; Belongs to the TMEM104 family. (496 aa)
KLHL33Kelch-like protein 33; Kelch like family member 33. (533 aa)
METTL24Methyltransferase-like protein 24; Methyltransferase like 24. (366 aa)
DALRD3DALR anticodon-binding domain-containing protein 3; DALR anticodon binding domain containing 3. (543 aa)
ECE2Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity); Belongs to the peptidase M13 family. (811 aa)
ETFBKMTElectron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain. (262 aa)
METTL9Methyltransferase-like protein 9; Methyltransferase like 9. (318 aa)
HSD17B11Estradiol 17-beta-dehydrogenase 11; Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A- dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. (300 aa)
DUSP27Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (1158 aa)
EEF1AKNMTeEF1A lysine and N-terminal methyltransferase; Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'. Has no activity towards core histones H2A, H2B, H3 and H4. (699 aa)
RRNAD1Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family. (475 aa)
EEF1AKMT2EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. (291 aa)
KLHL31Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). (634 aa)
OR2W1Olfactory receptor 2W1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. (320 aa)
CAMKMTCalmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of 'Lys-116' in calmodulin. Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family. (323 aa)
KINDNA/RNA-binding protein KIN17; Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. (393 aa)
METTL22Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN. Belongs to the methyltransferase superfamily. METTL22 family. (404 aa)
EEF1AKMT1EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family. (214 aa)
METTL7BMethyltransferase-like protein 7B; Probable methyltransferase. (244 aa)
VCPKMTProtein-lysine methyltransferase METTL21D; Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity; Belongs to the methyltransferase superfamily. METTL21 family. (229 aa)
ZNF676Zinc finger protein 676; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (588 aa)
ZNF195Zinc finger protein 195; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (629 aa)
KLHL30Kelch-like protein 30; Kelch like family member 30. (578 aa)
PREPLProlyl endopeptidase-like; Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis. (727 aa)
VSTM5V-set and transmembrane domain-containing protein 5; Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical [...] (200 aa)
EEF2KMTProtein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. (330 aa)
IQCDDynein regulatory complex protein 10; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the DRC10 family. (449 aa)
METTL11BAlpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation. (283 aa)
FBXO24F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (618 aa)
ATPSCKMTATP synthase subunit C lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia. (233 aa)
E9PBE3_HUMANUncharacterized protein. (544 aa)
ZNF721Zinc finger protein 721; May be involved in transcriptional regulation. (923 aa)
CSKMTCitrate synthase-lysine N-methyltransferase CSKMT, mitochondrial; Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methly group per binding event. (240 aa)
F5H423_HUMANUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (210 aa)
METTL26Methyltransferase like 26. (205 aa)
METTL7AMethyltransferase-like protein 7A; Probable methyltransferase. (244 aa)
CCDC32Coiled-coil domain containing 32. (194 aa)
ANTKMTAdenine nucleotide translocase lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4. (235 aa)
K7EN84_HUMANUncharacterized protein. (100 aa)
K7ERJ3_HUMANUncharacterized protein. (54 aa)
ALG1L2Putative glycosyltransferase ALG1L2; Putative glycosyltransferase. (215 aa)
METTL8mRNA N(3)-methylcytidine methyltransferase METTL8; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs. (407 aa)
METTL23Methyltransferase-like protein 23; Probable methyltransferase. (190 aa)
NTMT1N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed; Distributive alpha-N-methyltransferase that methylates the N- terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]- Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly [...] (223 aa)
C8orf89Putative uncharacterized protein C8orf89; Chromosome 8 open reading frame 89. (161 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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