(10 nodes) Mixed, incl. ELM2 domain, and RPK118-like, kinase domain network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TFAP4	Transcription factor AP-4; Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. (338 aa)
	ZNF710	Zinc finger protein 710; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (664 aa)
	ELMSAN1	Mitotic deacetylase-associated SANT domain protein. (1045 aa)
	DNTTIP1	Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. (329 aa)
	MIPEP	Mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size. (713 aa)
	ZNF541	Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis. (1346 aa)
	TRERF1	Transcriptional-regulating factor 1; Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. (1220 aa)
	RPS6KL1	Ribosomal protein S6 kinase like 1. (549 aa)
	ZNF524	Zinc finger protein 524; May be involved in transcriptional regulation. (264 aa)
	M0QYG6_HUMAN	Uncharacterized protein. (137 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNTTIP1	ELMSAN1	ENSP00000361705	ENSP00000286523	Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.	Mitotic deacetylase-associated SANT domain protein.	0.997
DNTTIP1	TRERF1	ENSP00000361705	ENSP00000439689	Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.	Transcriptional-regulating factor 1; Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.	0.970
DNTTIP1	ZNF541	ENSP00000361705	ENSP00000375770	Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.	Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.	0.726
ELMSAN1	DNTTIP1	ENSP00000286523	ENSP00000361705	Mitotic deacetylase-associated SANT domain protein.	Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.	0.997
ELMSAN1	TRERF1	ENSP00000286523	ENSP00000439689	Mitotic deacetylase-associated SANT domain protein.	Transcriptional-regulating factor 1; Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.	0.869
M0QYG6_HUMAN	ZNF541	ENSP00000469811	ENSP00000375770	Uncharacterized protein.	Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.	0.581
MIPEP	TFAP4	ENSP00000371607	ENSP00000204517	Mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size.	Transcription factor AP-4; Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.	0.497
RPS6KL1	ZNF524	ENSP00000450567	ENSP00000466907	Ribosomal protein S6 kinase like 1.	Zinc finger protein 524; May be involved in transcriptional regulation.	0.715
RPS6KL1	ZNF541	ENSP00000450567	ENSP00000375770	Ribosomal protein S6 kinase like 1.	Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.	0.680
RPS6KL1	ZNF710	ENSP00000450567	ENSP00000268154	Ribosomal protein S6 kinase like 1.	Zinc finger protein 710; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.672
TFAP4	MIPEP	ENSP00000204517	ENSP00000371607	Transcription factor AP-4; Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.	Mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size.	0.497
TRERF1	DNTTIP1	ENSP00000439689	ENSP00000361705	Transcriptional-regulating factor 1; Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.	Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.	0.970
TRERF1	ELMSAN1	ENSP00000439689	ENSP00000286523	Transcriptional-regulating factor 1; Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.	Mitotic deacetylase-associated SANT domain protein.	0.869
ZNF524	RPS6KL1	ENSP00000466907	ENSP00000450567	Zinc finger protein 524; May be involved in transcriptional regulation.	Ribosomal protein S6 kinase like 1.	0.715
ZNF541	DNTTIP1	ENSP00000375770	ENSP00000361705	Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.	Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.	0.726
ZNF541	M0QYG6_HUMAN	ENSP00000375770	ENSP00000469811	Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.	Uncharacterized protein.	0.581
ZNF541	RPS6KL1	ENSP00000375770	ENSP00000450567	Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.	Ribosomal protein S6 kinase like 1.	0.680
ZNF541	ZNF710	ENSP00000375770	ENSP00000268154	Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.	Zinc finger protein 710; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.518
ZNF710	RPS6KL1	ENSP00000268154	ENSP00000450567	Zinc finger protein 710; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	Ribosomal protein S6 kinase like 1.	0.672
ZNF710	ZNF541	ENSP00000268154	ENSP00000375770	Zinc finger protein 710; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.	0.518