(10 nodes) Keratin, type I network (Homo sapiens)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	KRT33A	Keratin, type I cuticular Ha3-I; Keratin 33A; Belongs to the intermediate filament family. (404 aa)
	KRT37	Keratin, type I cuticular Ha7; Keratin 37. (449 aa)
	KRT31	Keratin, type I cuticular Ha1; Keratin 31. (416 aa)
	KRT33B	Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family. (404 aa)
	KRT85	Keratin, type II cuticular Hb5; Keratin 85; Belongs to the intermediate filament family. (507 aa)
	KRT27	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). (459 aa)
	KRT74	Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). (529 aa)
	KRT25	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization. (450 aa)
	KRT35	Keratin, type I cuticular Ha5; Keratin 35; Belongs to the intermediate filament family. (455 aa)
	KRT34	Keratin, type I cuticular Ha4; Keratin 34. (436 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRT25	KRT27	ENSP00000310573	ENSP00000301656	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	0.879
KRT25	KRT31	ENSP00000310573	ENSP00000251645	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.	Keratin, type I cuticular Ha1; Keratin 31.	0.549
KRT25	KRT33A	ENSP00000310573	ENSP00000007735	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.	Keratin, type I cuticular Ha3-I; Keratin 33A; Belongs to the intermediate filament family.	0.539
KRT25	KRT33B	ENSP00000310573	ENSP00000251646	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.	Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family.	0.592
KRT25	KRT34	ENSP00000310573	ENSP00000377570	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.	Keratin, type I cuticular Ha4; Keratin 34.	0.559
KRT25	KRT35	ENSP00000310573	ENSP00000377558	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.	Keratin, type I cuticular Ha5; Keratin 35; Belongs to the intermediate filament family.	0.720
KRT25	KRT37	ENSP00000310573	ENSP00000225550	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.	Keratin, type I cuticular Ha7; Keratin 37.	0.487
KRT25	KRT74	ENSP00000310573	ENSP00000307240	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.	Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).	0.706
KRT25	KRT85	ENSP00000310573	ENSP00000257901	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.	Keratin, type II cuticular Hb5; Keratin 85; Belongs to the intermediate filament family.	0.507
KRT27	KRT25	ENSP00000301656	ENSP00000310573	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.	0.879
KRT27	KRT31	ENSP00000301656	ENSP00000251645	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	Keratin, type I cuticular Ha1; Keratin 31.	0.597
KRT27	KRT33A	ENSP00000301656	ENSP00000007735	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	Keratin, type I cuticular Ha3-I; Keratin 33A; Belongs to the intermediate filament family.	0.624
KRT27	KRT33B	ENSP00000301656	ENSP00000251646	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family.	0.672
KRT27	KRT34	ENSP00000301656	ENSP00000377570	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	Keratin, type I cuticular Ha4; Keratin 34.	0.636
KRT27	KRT35	ENSP00000301656	ENSP00000377558	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	Keratin, type I cuticular Ha5; Keratin 35; Belongs to the intermediate filament family.	0.855
KRT27	KRT37	ENSP00000301656	ENSP00000225550	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	Keratin, type I cuticular Ha7; Keratin 37.	0.493
KRT27	KRT74	ENSP00000301656	ENSP00000307240	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).	0.862
KRT27	KRT85	ENSP00000301656	ENSP00000257901	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	Keratin, type II cuticular Hb5; Keratin 85; Belongs to the intermediate filament family.	0.628
KRT31	KRT25	ENSP00000251645	ENSP00000310573	Keratin, type I cuticular Ha1; Keratin 31.	Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.	0.549
KRT31	KRT27	ENSP00000251645	ENSP00000301656	Keratin, type I cuticular Ha1; Keratin 31.	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	0.597