(9 nodes) Xylanase inhibitor N-terminal network (Homo sapiens)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	CTSD	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. (412 aa)
	ENSP00000489910	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (582 aa)
	CTSE	Cathepsin E form II; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Belongs to the peptidase A1 family. (396 aa)
	PGA3	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. (388 aa)
	PGA5	Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. (388 aa)
	PGA4	Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. (388 aa)
	REN	Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa)
	PGC	Gastricsin; Hydrolyzes a variety of proteins; Belongs to the peptidase A1 family. (388 aa)
	NAPSA	Napsin-A; May be involved in processing of pneumocyte surfactant precursors. (420 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTSD	ENSP00000489910	ENSP00000236671	ENSP00000489910	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.900
CTSD	NAPSA	ENSP00000236671	ENSP00000253719	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	0.625
CTSD	REN	ENSP00000236671	ENSP00000272190	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.	Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.	0.430
ENSP00000489910	CTSD	ENSP00000489910	ENSP00000236671	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.	0.900
NAPSA	CTSD	ENSP00000253719	ENSP00000236671	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.	0.625
NAPSA	PGA3	ENSP00000253719	ENSP00000322192	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	0.436
NAPSA	PGA4	ENSP00000253719	ENSP00000367391	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	0.436
NAPSA	PGA5	ENSP00000253719	ENSP00000309542	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	0.430
PGA3	NAPSA	ENSP00000322192	ENSP00000253719	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	0.436
PGA3	PGA4	ENSP00000322192	ENSP00000367391	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	0.980
PGA3	PGA5	ENSP00000322192	ENSP00000309542	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	0.904
PGA4	NAPSA	ENSP00000367391	ENSP00000253719	Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	0.436
PGA4	PGA3	ENSP00000367391	ENSP00000322192	Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	0.980
PGA4	PGA5	ENSP00000367391	ENSP00000309542	Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	0.976
PGA5	NAPSA	ENSP00000309542	ENSP00000253719	Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	Napsin-A; May be involved in processing of pneumocyte surfactant precursors.	0.430
PGA5	PGA3	ENSP00000309542	ENSP00000322192	Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	0.904
PGA5	PGA4	ENSP00000309542	ENSP00000367391	Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	0.976
REN	CTSD	ENSP00000272190	ENSP00000236671	Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.	0.430